Release of indomethacin from a novel chitosan microsphere prepared by a naturally occurring crosslinker: Examination of crosslinking and polycation-anionic drug interaction

Fwu Long Mi, Hsing Wen Sung, Shin Shing Shyu

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Novel chitosan microspheres with lower cytotoxicity were fabricated in this study and their drug release characteristics were investigated. Genipin, a naturally occurring crosslinking reagent that has been used in herbal medicine and in the production of food dye, was used to prepare crosslinked chitosan microspheres by a water-in-oil dispersion method. The crosslinking mechanism examined by FTIR and 13C-NMR suggests that the crosslinking of chitosan by genipin leads to the formation of secondary amide and heterocyclic amino linkage. The polycation-anionic drug interaction between chitosan and indomethacin was pH dependent and could affect the dissolution property of indomethacin. By examination of the release profiles of the crosslinked chitosan microsphere, it was found that the release of indomethacin from the microsphere was sustainable and influenced by factors such as crosslinking of microsphere and chitosan-indomethacin interaction, thus establishing crosslinked chitosan microsphere as a very promising polymeric carrier for drug release.

Original languageEnglish
Pages (from-to)1700-1711
Number of pages12
JournalJournal of Applied Polymer Science
Volume81
Issue number7
DOIs
Publication statusPublished - Aug 15 2001
Externally publishedYes

Keywords

  • Chitosan
  • Genipin
  • Microspheres
  • Naturally occurring crosslinker

ASJC Scopus subject areas

  • Polymers and Plastics

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