Relative cardiotoxicity and cytotoxicity of anthraquinonyl glucosaminosides

Jon W. Banning, Hanley N. Abramson, Henry C. Wormser, Jender Wu, Thomas H. Corbett

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The cardiotoxicity and cytotoxicity for tumor cells of four new synthetic anthraquinonyl glucosaminosides were compared in vitro. The nonhydroxylated anthraquinone was not cardiotoxic, and its cytotoxic activity was the weakest of the compounds in the series. Increasing the number of hydroxyl groups on the anthraquinone moiety increased the inhibition of growth of L-1210 leukemia cells and pancreatic or colonic adenocarcinomas in a soft agar colony formation assay. However, cardiotoxicity was also increased in proportion to the number of hydroxyl groups present. The adenocarcinomas were slightly more sensitive than the leukemias to the inhibitory action of the dihydroxylated anthraquinonyl glucosaminosides on cell growth.

Original languageEnglish
Pages (from-to)207-212
Number of pages6
JournalCancer Chemotherapy and Pharmacology
Volume19
Issue number3
DOIs
Publication statusPublished - May 1987
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Oncology
  • Cancer Research

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