Abstract

Chronic obstructive pulmonary disease (COPD) is caused by chronic inflammation. Many inflammatory mediators induce the low grade systemic inflammation of COPD. Haptoglobin (Hp) is synthesized in the liver and by lung epithelial and alveolar macrophage cells. However, associations of the serum concentration and phenotype of Hp with COPD are unclear. Therefore, we explored the association of the Hp concentration and Hp phenotype with the inflammatory response and COPD disease severity. We included healthy subjects and COPD patients. The Hp phenotype was categorized by SDS native-PAGE, and concentrations were determined by ELISA. In this trial Hp concentrations in COPD groups were significantly higher than those in healthy controls. There was a significant negative correlation between the Hp concentration and FEV1(%) (p 
Original languageEnglish
JournalScientific Reports
Volume9
Issue number1
DOIs
Publication statusPublished - 2019

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Haptoglobins
Chronic Obstructive Pulmonary Disease
Inflammation
Phenotype
Alveolar Epithelial Cells
Native Polyacrylamide Gel Electrophoresis
Alveolar Macrophages
Polyacrylamide Gel Electrophoresis
Healthy Volunteers
Enzyme-Linked Immunosorbent Assay
Lung
Liver
Serum

Cite this

@article{ebbe969ae9a7455191525fc72bfac064,
title = "Relationships of Haptoglobin Phenotypes with Systemic Inflammation and the Severity of Chronic Obstructive Pulmonary Disease",
abstract = "Chronic obstructive pulmonary disease (COPD) is caused by chronic inflammation. Many inflammatory mediators induce the low grade systemic inflammation of COPD. Haptoglobin (Hp) is synthesized in the liver and by lung epithelial and alveolar macrophage cells. However, associations of the serum concentration and phenotype of Hp with COPD are unclear. Therefore, we explored the association of the Hp concentration and Hp phenotype with the inflammatory response and COPD disease severity. We included healthy subjects and COPD patients. The Hp phenotype was categorized by SDS native-PAGE, and concentrations were determined by ELISA. In this trial Hp concentrations in COPD groups were significantly higher than those in healthy controls. There was a significant negative correlation between the Hp concentration and FEV1({\%}) (p ",
author = "Pao-Lin Lee and Kang-Yun Lee and Tsai-Mu Cheng and Hsiao-Chi Chuang and Sheng-Ming Wu and Po-Hao Feng and Wen-Te Liu and Kuan-Yuan Chen and Shu-Chuan Ho",
year = "2019",
doi = "10.1038/s41598-018-37406-9",
language = "English",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
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TY - JOUR

T1 - Relationships of Haptoglobin Phenotypes with Systemic Inflammation and the Severity of Chronic Obstructive Pulmonary Disease

AU - Lee, Pao-Lin

AU - Lee, Kang-Yun

AU - Cheng, Tsai-Mu

AU - Chuang, Hsiao-Chi

AU - Wu, Sheng-Ming

AU - Feng, Po-Hao

AU - Liu, Wen-Te

AU - Chen, Kuan-Yuan

AU - Ho, Shu-Chuan

PY - 2019

Y1 - 2019

N2 - Chronic obstructive pulmonary disease (COPD) is caused by chronic inflammation. Many inflammatory mediators induce the low grade systemic inflammation of COPD. Haptoglobin (Hp) is synthesized in the liver and by lung epithelial and alveolar macrophage cells. However, associations of the serum concentration and phenotype of Hp with COPD are unclear. Therefore, we explored the association of the Hp concentration and Hp phenotype with the inflammatory response and COPD disease severity. We included healthy subjects and COPD patients. The Hp phenotype was categorized by SDS native-PAGE, and concentrations were determined by ELISA. In this trial Hp concentrations in COPD groups were significantly higher than those in healthy controls. There was a significant negative correlation between the Hp concentration and FEV1(%) (p 

AB - Chronic obstructive pulmonary disease (COPD) is caused by chronic inflammation. Many inflammatory mediators induce the low grade systemic inflammation of COPD. Haptoglobin (Hp) is synthesized in the liver and by lung epithelial and alveolar macrophage cells. However, associations of the serum concentration and phenotype of Hp with COPD are unclear. Therefore, we explored the association of the Hp concentration and Hp phenotype with the inflammatory response and COPD disease severity. We included healthy subjects and COPD patients. The Hp phenotype was categorized by SDS native-PAGE, and concentrations were determined by ELISA. In this trial Hp concentrations in COPD groups were significantly higher than those in healthy controls. There was a significant negative correlation between the Hp concentration and FEV1(%) (p 

U2 - 10.1038/s41598-018-37406-9

DO - 10.1038/s41598-018-37406-9

M3 - Article

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

ER -