Relationship of interleukin-8 gene polymorphisms with hepatocellular carcinoma susceptibility and pathological development

Ming Hsien Chien, Chao Bin Yeh, Yi Ching Li, Lin Hung Wei, Jer Hwa Chang, Yu Ting Peng, Shun Fa Yang, Wu Hsien Kuo

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14 Citations (Scopus)

Abstract

Background and Objectives Hepatocellular carcinoma (HCC) is one of the most frequent malignant neoplasms worldwide, and the second leading cause of death from cancer in Taiwan. Interleukin-8 (IL-8) is an angiogenic chemokine with important roles in the development and progression of many human malignancies including HCC. This study investigates the effects of single-nucleotide polymorphisms (SNPs) in the IL-8 gene on the susceptibility and clinicopathological characteristics of HCC. Methods One hundred thirty-one HCC patients and 340 control subjects were analyzed for four IL-8 SNPs (-251 T/A, +781 C/T, +1633 C/T, and +2767 A/T) using PCR-RFLP genotyping analysis. Results After adjusting for other confounders, results show that individuals with the IL-8 +781 T/T polymorphic genotype had a significantly lower risk of developing HCC than those with the wild-type (C/C) genotype (AOR = 0.346; 95% CI: 0.132-0.909). Multiple regression analysis showed that the presence of T/A or A/A at IL-8 -251 may indicate higher potential risk of hepatitis B infection (AOR = 2.847; 95% CI: 1.083-8.656). Additionally, these four IL-8 SNPs did not associate with liver-related clinicopathological markers in serum. Conclusions Genetic polymorphism at IL-8 +781 is an important factor in determining susceptibility to HCC in the Taiwanese population. J. Surg. Oncol. 2011; 104:798-803. © 2011 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)798-803
Number of pages6
JournalJournal of Surgical Oncology
Volume104
Issue number7
DOIs
Publication statusPublished - Dec 2011

Keywords

  • genetic polymorphism
  • hepatocellular carcinoma
  • interleukin-8

ASJC Scopus subject areas

  • Surgery
  • Oncology

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