Relationship of blood pressure and cardiovascular disease risk factors in normotensive middle-aged men

Dee Pei, Yen Lin Chen, Sai Hung Tang, Chung Ze Wu, Jiunn Diann Lin, Yen Ling Chang, Chun Hsien Hsu, Cheng Yi Wang, Kun Wang, Jen Yu Wang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We conducted this study to investigate whether subjects with high-normal systolic blood pressure (SBP) have an increased risk of cardiovascular disease (CVD) and/or diabetes compared to subjects with low-normal SBP, using metabolic syndrome (MetS) as a risk factor for future CVD/diabetes.The study included 6133 apparently healthy Taiwanese men aged 40-65 years. All subjects were normotensive, and none took medication for any abnormal MetS component. To avoid the effect of age on blood pressure, we stratified patients first by age then by SBP (that is, low, middle, and high SBP). We pooled all the low, middle, and high SBP groups from the different age strata to create 3 larger groups (Group 1, Group 2, and Group 3, respectively). The MetS components in subjects with the lowest SBP (Group 1) were compared with those in the other 2 groups. All of the MetS components, except for high-density lipoprotein cholesterol (HDL-C), were significantly lower in Group 1. Thus, it was not surprising that Group 2 and Group 3 had significantly higher odds ratios for abnormal body mass index, fasting plasma glucose, low-density lipoprotein-cholesterol (LDL-C), and triglycerides than Group 1 (but not for HDL-C). Specifically, Group 3 had a 1.7-fold higher odds ratio (p <0.001) for having MetS than Group 1. Age, body mass index, fasting plasma glucose, LDL-C, and log triglycerides correlated significantly with SBP. In multivariate linear regression analysis, we found that only body mass index, fasting plasma glucose, and log triglycerides remained significantly related to SBP. Among them, body mass index had the highest β value.In conclusion, the level of SBP was highly correlated with body mass index, fasting plasma glucose, and triglycerides in subjects with normotension. Although there is not a cause-and-effect relationship, the risk of CVD and diabetes was significantly associated with an elevation of SBP, even when the SBP remained within the normal range. Further studies are needed to determine whether normotensive subjects would benefit from medical management.

Original languageEnglish
Pages (from-to)344-349
Number of pages6
JournalMedicine (United States)
Volume90
Issue number5
DOIs
Publication statusPublished - Sep 2011

Fingerprint

Hematologic Diseases
Cardiovascular Diseases
Blood Pressure
Body Mass Index
Fasting
Glucose
Triglycerides
Blood Group Antigens
LDL Cholesterol
HDL Cholesterol
Odds Ratio
Hypertension

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Relationship of blood pressure and cardiovascular disease risk factors in normotensive middle-aged men. / Pei, Dee; Chen, Yen Lin; Tang, Sai Hung; Wu, Chung Ze; Lin, Jiunn Diann; Chang, Yen Ling; Hsu, Chun Hsien; Wang, Cheng Yi; Wang, Kun; Wang, Jen Yu.

In: Medicine (United States), Vol. 90, No. 5, 09.2011, p. 344-349.

Research output: Contribution to journalArticle

Pei, Dee ; Chen, Yen Lin ; Tang, Sai Hung ; Wu, Chung Ze ; Lin, Jiunn Diann ; Chang, Yen Ling ; Hsu, Chun Hsien ; Wang, Cheng Yi ; Wang, Kun ; Wang, Jen Yu. / Relationship of blood pressure and cardiovascular disease risk factors in normotensive middle-aged men. In: Medicine (United States). 2011 ; Vol. 90, No. 5. pp. 344-349.
@article{6c31b93fb1984716b3ec3fef28bc609f,
title = "Relationship of blood pressure and cardiovascular disease risk factors in normotensive middle-aged men",
abstract = "We conducted this study to investigate whether subjects with high-normal systolic blood pressure (SBP) have an increased risk of cardiovascular disease (CVD) and/or diabetes compared to subjects with low-normal SBP, using metabolic syndrome (MetS) as a risk factor for future CVD/diabetes.The study included 6133 apparently healthy Taiwanese men aged 40-65 years. All subjects were normotensive, and none took medication for any abnormal MetS component. To avoid the effect of age on blood pressure, we stratified patients first by age then by SBP (that is, low, middle, and high SBP). We pooled all the low, middle, and high SBP groups from the different age strata to create 3 larger groups (Group 1, Group 2, and Group 3, respectively). The MetS components in subjects with the lowest SBP (Group 1) were compared with those in the other 2 groups. All of the MetS components, except for high-density lipoprotein cholesterol (HDL-C), were significantly lower in Group 1. Thus, it was not surprising that Group 2 and Group 3 had significantly higher odds ratios for abnormal body mass index, fasting plasma glucose, low-density lipoprotein-cholesterol (LDL-C), and triglycerides than Group 1 (but not for HDL-C). Specifically, Group 3 had a 1.7-fold higher odds ratio (p <0.001) for having MetS than Group 1. Age, body mass index, fasting plasma glucose, LDL-C, and log triglycerides correlated significantly with SBP. In multivariate linear regression analysis, we found that only body mass index, fasting plasma glucose, and log triglycerides remained significantly related to SBP. Among them, body mass index had the highest β value.In conclusion, the level of SBP was highly correlated with body mass index, fasting plasma glucose, and triglycerides in subjects with normotension. Although there is not a cause-and-effect relationship, the risk of CVD and diabetes was significantly associated with an elevation of SBP, even when the SBP remained within the normal range. Further studies are needed to determine whether normotensive subjects would benefit from medical management.",
author = "Dee Pei and Chen, {Yen Lin} and Tang, {Sai Hung} and Wu, {Chung Ze} and Lin, {Jiunn Diann} and Chang, {Yen Ling} and Hsu, {Chun Hsien} and Wang, {Cheng Yi} and Kun Wang and Wang, {Jen Yu}",
year = "2011",
month = "9",
doi = "10.1097/MD.0b013e31822a3852",
language = "English",
volume = "90",
pages = "344--349",
journal = "Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries",
issn = "0025-7974",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Relationship of blood pressure and cardiovascular disease risk factors in normotensive middle-aged men

AU - Pei, Dee

AU - Chen, Yen Lin

AU - Tang, Sai Hung

AU - Wu, Chung Ze

AU - Lin, Jiunn Diann

AU - Chang, Yen Ling

AU - Hsu, Chun Hsien

AU - Wang, Cheng Yi

AU - Wang, Kun

AU - Wang, Jen Yu

PY - 2011/9

Y1 - 2011/9

N2 - We conducted this study to investigate whether subjects with high-normal systolic blood pressure (SBP) have an increased risk of cardiovascular disease (CVD) and/or diabetes compared to subjects with low-normal SBP, using metabolic syndrome (MetS) as a risk factor for future CVD/diabetes.The study included 6133 apparently healthy Taiwanese men aged 40-65 years. All subjects were normotensive, and none took medication for any abnormal MetS component. To avoid the effect of age on blood pressure, we stratified patients first by age then by SBP (that is, low, middle, and high SBP). We pooled all the low, middle, and high SBP groups from the different age strata to create 3 larger groups (Group 1, Group 2, and Group 3, respectively). The MetS components in subjects with the lowest SBP (Group 1) were compared with those in the other 2 groups. All of the MetS components, except for high-density lipoprotein cholesterol (HDL-C), were significantly lower in Group 1. Thus, it was not surprising that Group 2 and Group 3 had significantly higher odds ratios for abnormal body mass index, fasting plasma glucose, low-density lipoprotein-cholesterol (LDL-C), and triglycerides than Group 1 (but not for HDL-C). Specifically, Group 3 had a 1.7-fold higher odds ratio (p <0.001) for having MetS than Group 1. Age, body mass index, fasting plasma glucose, LDL-C, and log triglycerides correlated significantly with SBP. In multivariate linear regression analysis, we found that only body mass index, fasting plasma glucose, and log triglycerides remained significantly related to SBP. Among them, body mass index had the highest β value.In conclusion, the level of SBP was highly correlated with body mass index, fasting plasma glucose, and triglycerides in subjects with normotension. Although there is not a cause-and-effect relationship, the risk of CVD and diabetes was significantly associated with an elevation of SBP, even when the SBP remained within the normal range. Further studies are needed to determine whether normotensive subjects would benefit from medical management.

AB - We conducted this study to investigate whether subjects with high-normal systolic blood pressure (SBP) have an increased risk of cardiovascular disease (CVD) and/or diabetes compared to subjects with low-normal SBP, using metabolic syndrome (MetS) as a risk factor for future CVD/diabetes.The study included 6133 apparently healthy Taiwanese men aged 40-65 years. All subjects were normotensive, and none took medication for any abnormal MetS component. To avoid the effect of age on blood pressure, we stratified patients first by age then by SBP (that is, low, middle, and high SBP). We pooled all the low, middle, and high SBP groups from the different age strata to create 3 larger groups (Group 1, Group 2, and Group 3, respectively). The MetS components in subjects with the lowest SBP (Group 1) were compared with those in the other 2 groups. All of the MetS components, except for high-density lipoprotein cholesterol (HDL-C), were significantly lower in Group 1. Thus, it was not surprising that Group 2 and Group 3 had significantly higher odds ratios for abnormal body mass index, fasting plasma glucose, low-density lipoprotein-cholesterol (LDL-C), and triglycerides than Group 1 (but not for HDL-C). Specifically, Group 3 had a 1.7-fold higher odds ratio (p <0.001) for having MetS than Group 1. Age, body mass index, fasting plasma glucose, LDL-C, and log triglycerides correlated significantly with SBP. In multivariate linear regression analysis, we found that only body mass index, fasting plasma glucose, and log triglycerides remained significantly related to SBP. Among them, body mass index had the highest β value.In conclusion, the level of SBP was highly correlated with body mass index, fasting plasma glucose, and triglycerides in subjects with normotension. Although there is not a cause-and-effect relationship, the risk of CVD and diabetes was significantly associated with an elevation of SBP, even when the SBP remained within the normal range. Further studies are needed to determine whether normotensive subjects would benefit from medical management.

UR - http://www.scopus.com/inward/record.url?scp=80052448297&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052448297&partnerID=8YFLogxK

U2 - 10.1097/MD.0b013e31822a3852

DO - 10.1097/MD.0b013e31822a3852

M3 - Article

C2 - 21857368

AN - SCOPUS:80052448297

VL - 90

SP - 344

EP - 349

JO - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries

JF - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries

SN - 0025-7974

IS - 5

ER -