Relationship between white blood cell count and components of metabolic syndrome among young adolescents

Chung Z. Wu, Fone Ching Hsiao, Juinn Diann Lin, Ching Chieh Su, Kwo Syin Wang, Yi M. Chu, Li Hsiu Lee, Kun Wang, Te L. Hsia, Dee Pei

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Components of metabolic syndrome (MetS) have been associated with several inflammatory factors, including white blood cell count (WBCC). In the present study, the relationships between WBCC and aspects of MetS in young adolescents were investigated. We enrolled 596 participants (328 males and 268 females) from 10 to 13 years of age and with normal WBCC in this study. They were divided into four quartiles according to WBCC (WBCC1-4, from lowest to highest WBCC). The mean values of MetS components for each group were compared in males and females separately. Multivariate linear regression analysis between the WBCC and the components of MetS after adjusted for age and body mass index (BMI) were also evaluated. In the male group, the BMI of WBCC1 and WBCC2 was significantly lower than WBCC4. The total cholesterol and low-density lipoprotein-cholesterol (LDL-C) of WBCC2 were significantly higher than WBCC1 and WBCC4. Triglyceride (TG) levels of WBCC1 were significantly lower than WBCC3 and WBCC4, and TG levels of WBCC2 were significantly lower than WBCC4. Alternatively, the BMI of WBCC1 and WBCC2 were significantly lower than WBCC3 in the female group. Finally, the TG and fasting plasma glucose (FPG) levels of WBCC1 were significantly lower than WBCC3 or WBCC4, respectively. After multivariate linear regression, WBCC was positively correlated to BMI and TG, but negatively correlated to FPG in males whereas in young adolescent females, WBCC was positively correlated to BMI and FPG. In conclusion BMI was positively correlated with WBCC in young adolescent females and males. Thus, BMI is the most important component of MetS in this age group. In addition, TG levels in males and FPG in females were significantly related to WBCC. These findings could be regarded an early indication for the future development of full-blown MetS or cardiovascular diseases.

Original languageEnglish
Pages (from-to)65-71
Number of pages7
JournalActa Diabetologica
Volume47
Issue number1
DOIs
Publication statusPublished - Mar 2010

Fingerprint

Cellular Structures
Leukocyte Count
Body Mass Index
Triglycerides
Fasting
Glucose
Linear Models
Young Syndrome
Metabolic Diseases
LDL Cholesterol
Cardiovascular Diseases
Age Groups
Cholesterol
Regression Analysis

Keywords

  • Body mass index
  • Metabolic syndrome
  • Triglyceride
  • White blood cell count
  • Young adolescents

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Relationship between white blood cell count and components of metabolic syndrome among young adolescents. / Wu, Chung Z.; Hsiao, Fone Ching; Lin, Juinn Diann; Su, Ching Chieh; Wang, Kwo Syin; Chu, Yi M.; Lee, Li Hsiu; Wang, Kun; Hsia, Te L.; Pei, Dee.

In: Acta Diabetologica, Vol. 47, No. 1, 03.2010, p. 65-71.

Research output: Contribution to journalArticle

Wu, Chung Z. ; Hsiao, Fone Ching ; Lin, Juinn Diann ; Su, Ching Chieh ; Wang, Kwo Syin ; Chu, Yi M. ; Lee, Li Hsiu ; Wang, Kun ; Hsia, Te L. ; Pei, Dee. / Relationship between white blood cell count and components of metabolic syndrome among young adolescents. In: Acta Diabetologica. 2010 ; Vol. 47, No. 1. pp. 65-71.
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abstract = "Components of metabolic syndrome (MetS) have been associated with several inflammatory factors, including white blood cell count (WBCC). In the present study, the relationships between WBCC and aspects of MetS in young adolescents were investigated. We enrolled 596 participants (328 males and 268 females) from 10 to 13 years of age and with normal WBCC in this study. They were divided into four quartiles according to WBCC (WBCC1-4, from lowest to highest WBCC). The mean values of MetS components for each group were compared in males and females separately. Multivariate linear regression analysis between the WBCC and the components of MetS after adjusted for age and body mass index (BMI) were also evaluated. In the male group, the BMI of WBCC1 and WBCC2 was significantly lower than WBCC4. The total cholesterol and low-density lipoprotein-cholesterol (LDL-C) of WBCC2 were significantly higher than WBCC1 and WBCC4. Triglyceride (TG) levels of WBCC1 were significantly lower than WBCC3 and WBCC4, and TG levels of WBCC2 were significantly lower than WBCC4. Alternatively, the BMI of WBCC1 and WBCC2 were significantly lower than WBCC3 in the female group. Finally, the TG and fasting plasma glucose (FPG) levels of WBCC1 were significantly lower than WBCC3 or WBCC4, respectively. After multivariate linear regression, WBCC was positively correlated to BMI and TG, but negatively correlated to FPG in males whereas in young adolescent females, WBCC was positively correlated to BMI and FPG. In conclusion BMI was positively correlated with WBCC in young adolescent females and males. Thus, BMI is the most important component of MetS in this age group. In addition, TG levels in males and FPG in females were significantly related to WBCC. These findings could be regarded an early indication for the future development of full-blown MetS or cardiovascular diseases.",
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