Relationship Between Statin Use and Outcomes in Patients Having Cardiac Arrest (from a Nationwide Cohort Study in Taiwan)

Chien Hua Huang, Ping Hsun Yu, Min Shan Tsai, Hui Chun Huang, Tzung Dau Wang, Wei Tien Chang, Chao Hsiun Tang, Wen Jone Chen

Research output: Contribution to journalArticle

Abstract

Pretreatment with statins is associated with improved outcomes in severe sepsis, acute coronary syndrome, and stroke. Patients with cardiac arrest experience sepsis-like syndrome and ischemia reperfusion injuries in the heart and brain. The objective of this study was to investigate the effects of statin use before cardiac arrest on outcomes in cardiac arrest patients. Medical records of 142,131 adult patients who experienced nontraumatic cardiac arrest and were resuscitated between 2004 and 2011 were analyzed. Patients were grouped into 2 groups: the “statin group” comprised patients who had received statin treatment for at least 30 days before the cardiac arrest event; the “never statin group” comprised patients who had no statin use within 30 days before the event. Patients with previous statin treatment had better chance of survival to hospital discharge (6.1% vs 4.3%, p <0.0001) and 1-year survival (4.8% vs 3.2%, p <0.0001) after propensity score matching. Previous statin use was an independent predictor for 1-year survival (adjusted odds ratio 1.41, 95% confidence interval 1.16 to 1.71; p = 0.001). A favorable outcome effect of statin on 1-year survival was observed in the presence of diabetes mellitus, chronic kidney disease, and Charlson Comorbidity Index score greater than 5 in the subgroup analysis. In conclusion, statin use before cardiac arrest is associated with 1-year survival in a propensity score-matched nationwide cohort study.

Original languageEnglish
Pages (from-to)1572-1579
Number of pages8
JournalAmerican Journal of Cardiology
Volume123
Issue number10
DOIs
Publication statusPublished - May 15 2019

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Heart Arrest
Taiwan
Cohort Studies
Survival
Propensity Score
Systemic Inflammatory Response Syndrome
Acute Coronary Syndrome
Reperfusion Injury
Chronic Renal Insufficiency
Medical Records
Comorbidity
Sepsis
Diabetes Mellitus
Stroke
Odds Ratio
Confidence Intervals

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Relationship Between Statin Use and Outcomes in Patients Having Cardiac Arrest (from a Nationwide Cohort Study in Taiwan). / Huang, Chien Hua; Yu, Ping Hsun; Tsai, Min Shan; Huang, Hui Chun; Wang, Tzung Dau; Chang, Wei Tien; Tang, Chao Hsiun; Chen, Wen Jone.

In: American Journal of Cardiology, Vol. 123, No. 10, 15.05.2019, p. 1572-1579.

Research output: Contribution to journalArticle

Huang, Chien Hua ; Yu, Ping Hsun ; Tsai, Min Shan ; Huang, Hui Chun ; Wang, Tzung Dau ; Chang, Wei Tien ; Tang, Chao Hsiun ; Chen, Wen Jone. / Relationship Between Statin Use and Outcomes in Patients Having Cardiac Arrest (from a Nationwide Cohort Study in Taiwan). In: American Journal of Cardiology. 2019 ; Vol. 123, No. 10. pp. 1572-1579.
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