Relationship between matrix metalloproteinase-2 activity and cystatin C levels in patients with hepatic disease

Tzy Yen Chen, Yih Shou Hsieh, Chi Chieh Yang, Chi Ping Wang, Shun Fa Yang, Yan Wen Cheng, Hui Ling Chiou

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12 Citations (Scopus)

Abstract

Objectives: A direct relationship between cystatin C levels and the severity of hepatic disease has been revealed in our previous study. This study was aimed to consider whether a correlation exists between matrix metalloproteinases (MMPs), which have been proven to be involved in liver cirrhosis, and cystatin C to reflect the severity of hepatic disease. Design and Methods: A total of 154 consecutive patients with various liver diseases were recruited to determine their serum levels of cystatin C, MMP-2 and-9, together with other hepatic parameters. These were compared with 40 normal controls. Results: Average levels of MMP-2 and cystatin C were significantly higher in patients while MMP-9 was significantly lower, as compared to controls. A linear regression analysis has revealed a direct relationship between cystatin C and MMP-2 (Y = 83.39 + 270.56X, R = 0.38, P <0.001), as well as between MMP-2 and the severity of liver diseases. Conclusion: This is the first study to demonstrate a correlation between cystatin C and MMP-2, suggesting that there may be certain interactions between cystatin C and MMP-2 in patients with hepatic diseases.

Original languageEnglish
Pages (from-to)632-638
Number of pages7
JournalClinical Biochemistry
Volume38
Issue number7
DOIs
Publication statusPublished - Jul 2005
Externally publishedYes

Keywords

  • Cystatin C
  • Hepatic disease
  • MMP-2

ASJC Scopus subject areas

  • Clinical Biochemistry

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    Chen, T. Y., Hsieh, Y. S., Yang, C. C., Wang, C. P., Yang, S. F., Cheng, Y. W., & Chiou, H. L. (2005). Relationship between matrix metalloproteinase-2 activity and cystatin C levels in patients with hepatic disease. Clinical Biochemistry, 38(7), 632-638. https://doi.org/10.1016/j.clinbiochem.2005.03.005