Relationship between fatty liver, alanine aminotransferase, HBsAg and hepatitis C virus

W. ‐Y CHANG, C. ‐J CHEN, S. ‐N LU, S. ‐L YOU, W. ‐L CHUANG, S. ‐C CHEN, W. ‐P SU, L. ‐Y WANG, M. ‐Y HSIEH, M. ‐M WU, T. ‐Y TAI

Research output: Contribution to journalArticle

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Abstract

A community health survey of 923 residents aged 30 years or more was performed in Putai Township of Taiwan. To elucidate the relationships between hepatitis C virus (HCV) and surrogate tests for non‐A, non‐B hepatitis in hyperendemic areas of hepatitis B virus (HBV) serum levels of alanine aminotransferase (ALT), triglycerides, cholesterol, hepatitis B surface antigen (HBsAg) and antibody to HCV (anti‐HCV) were examined. Glucose tolerance tests and the history of diabetes treatment were used to define the diabetes status. Fatty liver was diagnosed by sonography. The prevalence of anti‐HCV was 2.6% (95% confidence interval, 1.6–3.6%). Elevated ALT and fatty liver were significantly associated with anti‐HCV in univariate analysis. Anti‐HCV was not an associated factor for fatty liver after adjusting for serum triglycerides and cholesterol, sex, body mass index and diabetes status through multiple logistic regression. However elevated ALT was still associated with anti‐HCV after adjusting for serum triglycerides, sex, body mass index, HBsAg and age through multiple linear regression. The anti‐HCV prevalence was similar between HBsAg‐positive and negative subjects. Aggregation of HCV infection was found among spouses. It was concluded that elevated ALT and intimate contact with HCV carriers might be associated factors for HCV infection, and that HBV infection and fatty liver were not related to HCV infection in Taiwan.

Original languageEnglish
Pages (from-to)455-458
Number of pages4
JournalJournal of Gastroenterology and Hepatology
Volume7
Issue number5
DOIs
Publication statusPublished - Jan 1 1992
Externally publishedYes

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Fatty Liver
Hepatitis B Surface Antigens
Alanine Transaminase
Hepacivirus
Hepatitis C Antibodies
Virus Diseases
Triglycerides
Taiwan
Hepatitis B virus
Body Mass Index
Serum
Cholesterol
Hepatitis B Antibodies
Glucose Tolerance Test
Health Surveys
Spouses
Hepatitis
Linear Models
Ultrasonography
Logistic Models

Keywords

  • alanine transaminase
  • Chinese
  • community survey
  • fatty liver
  • hepatitis B surface antigen
  • hepatitis C virus.

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

CHANG, W. Y., CHEN, C. J., LU, S. N., YOU, S. L., CHUANG, W. L., CHEN, S. C., ... TAI, T. Y. (1992). Relationship between fatty liver, alanine aminotransferase, HBsAg and hepatitis C virus. Journal of Gastroenterology and Hepatology, 7(5), 455-458. https://doi.org/10.1111/j.1440-1746.1992.tb01019.x

Relationship between fatty liver, alanine aminotransferase, HBsAg and hepatitis C virus. / CHANG, W. ‐Y; CHEN, C. ‐J; LU, S. ‐N; YOU, S. ‐L; CHUANG, W. ‐L; CHEN, S. ‐C; SU, W. ‐P; WANG, L. ‐Y; HSIEH, M. ‐Y; WU, M. ‐M; TAI, T. ‐Y.

In: Journal of Gastroenterology and Hepatology, Vol. 7, No. 5, 01.01.1992, p. 455-458.

Research output: Contribution to journalArticle

CHANG, WY, CHEN, CJ, LU, SN, YOU, SL, CHUANG, WL, CHEN, SC, SU, WP, WANG, LY, HSIEH, MY, WU, MM & TAI, TY 1992, 'Relationship between fatty liver, alanine aminotransferase, HBsAg and hepatitis C virus', Journal of Gastroenterology and Hepatology, vol. 7, no. 5, pp. 455-458. https://doi.org/10.1111/j.1440-1746.1992.tb01019.x
CHANG, W. ‐Y ; CHEN, C. ‐J ; LU, S. ‐N ; YOU, S. ‐L ; CHUANG, W. ‐L ; CHEN, S. ‐C ; SU, W. ‐P ; WANG, L. ‐Y ; HSIEH, M. ‐Y ; WU, M. ‐M ; TAI, T. ‐Y. / Relationship between fatty liver, alanine aminotransferase, HBsAg and hepatitis C virus. In: Journal of Gastroenterology and Hepatology. 1992 ; Vol. 7, No. 5. pp. 455-458.
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