Relationship between age and clinical characteristics of patients with gastric cancer

Su Shun Lo, Chew Wun Wu, Mao-Chih Hsieh, Hsu Sung Kuo, Wing Yiu Lui, Fang Ku P'eng

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The relationship between the prognosis and age of patients with gastric cancer is controversial. To evaluate whether there is a biological characteristic specific to the age of patients, we examined the clinical characteristics of patients with gastric cancer with special reference to their age. Based on a prospective database, a retrospective study of 419 patients who underwent radical gastrectomy for cure in the past 6 years was conducted. Clinical characteristics including gender, gross appearance of the tumour (Borrmann's classification, tumour location), histopathology (depth of tumour invasion, lymph node status, Lauren's classification and degree of tumour cell differentiation) and TNM tumour stage were analysed in six different age groups (< 39, 40-49, 50-59, 60-69, 70-79, > 80 years). The mean age of the 419 patients was 64.6 years (range from 26-91) and the peak age incidence of gastric cancer (46.3%) was in the 60-69 year old age group. The male : female ratio was 4.6 : 1 on the whole and male gender predominated at ages > 60. The proportion of diffuse type rumours (68.4%) by Lauren's criteria in the young age group (< 39 yrs) decreased with age (25% in the > 80 years group; P < 0.001). Similarly, the proportion of poorly-differentiate tumours (89.5%) in the young age group (< 39 yrs) decreased with advancing age (P < 0.001). These findings suggest that both diffuse type and poorly-differentiate tumours predominate in younger patients and, without considering the factor of delay in diagnosis, may explain the poorer prognosis demonstrated in younger patients.

Original languageEnglish
Pages (from-to)511-514
Number of pages4
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume11
Issue number6
DOIs
Publication statusPublished - Jan 1 1996
Externally publishedYes

Fingerprint

Stomach Neoplasms
Age Groups
Neoplasms
Gastrectomy
Cell Differentiation
Retrospective Studies
Lymph Nodes
Databases
Incidence

Keywords

  • Age
  • Gastric cancer
  • Lauren's classification
  • Tumour cell differentiation

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Relationship between age and clinical characteristics of patients with gastric cancer. / Lo, Su Shun; Wu, Chew Wun; Hsieh, Mao-Chih; Kuo, Hsu Sung; Lui, Wing Yiu; P'eng, Fang Ku.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 11, No. 6, 01.01.1996, p. 511-514.

Research output: Contribution to journalArticle

Lo, Su Shun ; Wu, Chew Wun ; Hsieh, Mao-Chih ; Kuo, Hsu Sung ; Lui, Wing Yiu ; P'eng, Fang Ku. / Relationship between age and clinical characteristics of patients with gastric cancer. In: Journal of Gastroenterology and Hepatology (Australia). 1996 ; Vol. 11, No. 6. pp. 511-514.
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