Relation of number of positive lymph nodes to the prognosis of patients with primary gastric adenocarcinoma

C. W. Wu, Mao-Chih Hsieh, S. S. Lo, S. H. Tsay, W. Y. Lui, F. K. P'eng

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Background - No nodal grouping category of gastric cancer has been universally accepted for the grading of the effectiveness of therapeutic regimens. Aims - To establish an appropriate nodal grouping as a forecaster of distant disease and test its validity as a determinant in survival. Patients - Five hundred and ten patients who underwent curative resections for gastric cancer were studied. Methods - Retrospectively analyse the prognostic significance of the number of metastatic lymph nodes. Results - A total of 17176 lymph nodes with an average of 34 per specimen were removed, of which 2811 (16%) showed metastases. Among the 510 patients, 287 (56%) had lymph node metastases, with an average of 9.8 per metastatic case. The survival of all patients was related to their nodal status, an abrupt decrease in survival was seen between 0 and 1 and 4 compared with 5 or more modes while little difference in survival existed among 1, 2, 3, and 4, and among 5, 6, 7, and 8 positive nodes. Multivariate analysis showed that the number of positive nodes (1-4, 5-8 versus ≥9; relative risk 2.2) and depth of cancer invasion (three levels; relative risk 1.9) were independently correlated with survival. The current nodal stage was not a prognostic factor. Conclusions - Gastric cancer patients with 0, 1 to 4, 5 to 8, and >9 positive nodes may represent four appropriate prognostic groups and should be adopted for classification of nodal stage in gastric cancer.

Original languageEnglish
Pages (from-to)525-527
Number of pages3
JournalGut
Volume38
Issue number4
DOIs
Publication statusPublished - Jan 1 1996
Externally publishedYes

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Stomach
Adenocarcinoma
Lymph Nodes
Stomach Neoplasms
Survival
Neoplasm Metastasis
Multivariate Analysis
Neoplasms
Therapeutics

Keywords

  • Gastric cancer
  • Positive nodes
  • Prognostic survival

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Relation of number of positive lymph nodes to the prognosis of patients with primary gastric adenocarcinoma. / Wu, C. W.; Hsieh, Mao-Chih; Lo, S. S.; Tsay, S. H.; Lui, W. Y.; P'eng, F. K.

In: Gut, Vol. 38, No. 4, 01.01.1996, p. 525-527.

Research output: Contribution to journalArticle

Wu, C. W. ; Hsieh, Mao-Chih ; Lo, S. S. ; Tsay, S. H. ; Lui, W. Y. ; P'eng, F. K. / Relation of number of positive lymph nodes to the prognosis of patients with primary gastric adenocarcinoma. In: Gut. 1996 ; Vol. 38, No. 4. pp. 525-527.
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N2 - Background - No nodal grouping category of gastric cancer has been universally accepted for the grading of the effectiveness of therapeutic regimens. Aims - To establish an appropriate nodal grouping as a forecaster of distant disease and test its validity as a determinant in survival. Patients - Five hundred and ten patients who underwent curative resections for gastric cancer were studied. Methods - Retrospectively analyse the prognostic significance of the number of metastatic lymph nodes. Results - A total of 17176 lymph nodes with an average of 34 per specimen were removed, of which 2811 (16%) showed metastases. Among the 510 patients, 287 (56%) had lymph node metastases, with an average of 9.8 per metastatic case. The survival of all patients was related to their nodal status, an abrupt decrease in survival was seen between 0 and 1 and 4 compared with 5 or more modes while little difference in survival existed among 1, 2, 3, and 4, and among 5, 6, 7, and 8 positive nodes. Multivariate analysis showed that the number of positive nodes (1-4, 5-8 versus ≥9; relative risk 2.2) and depth of cancer invasion (three levels; relative risk 1.9) were independently correlated with survival. The current nodal stage was not a prognostic factor. Conclusions - Gastric cancer patients with 0, 1 to 4, 5 to 8, and >9 positive nodes may represent four appropriate prognostic groups and should be adopted for classification of nodal stage in gastric cancer.

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