Relation of Coronary Artery Calcium to Flow-Mediated Dilation and C-Reactive Protein Levels in Asymptomatic Patients With Heterozygous Familial Hypercholesterolemia

Zhong Xuan Ye, Hao Ming Cheng, Kuan Rau Chiou, Po Hsun Huang, Shing Jong Lin, Min Ji Charng

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Abstract

The extent of coronary artery calcium (CAC) is correlated with coronary artery disease prognosis. However, the relation of CAC to endothelial function and high-sensitivity C-reactive protein (hs-CRP) in patients with asymptomatic heterozygous familial hypercholesterolemia (FH) requires clarification. The study aim was to investigate the relations among CAC, endothelial function, and hs-CRP in patients with asymptomatic heterozygous FH. Thirty-two patients with asymptomatic heterozygous FH (mean age 42 years) and 34 healthy control subjects (mean age 36 years) were enrolled. We measured CAC by electron-beam computed tomography and endothelial function by flow-mediated dilation of the brachial artery. A higher percentage of patients with FH had a positive CAC score compared with the control group. Comparing the FH group with detectable CAC (CAC score >0) and undetectable CAC (CAC score of 0), we found higher hs-CRP levels (0.29 ± 0.23 vs 0.07 ± 0.08 mg/dl, p = 0.001) and reduced flow-mediated dilation (0.04 ± 0.03 vs 0.08 ± 0.03, p = 0.005) in the detectable CAC group. Multivariate analysis showed an independent correlation of hs-CRP with detectable CAC (relative risk 5.034, 95% confidence interval 1.525 to 16.613, p = 0.04). In conclusion, FH subjects with positive CAC scores have decreased flow-mediated dilation and increased hs-CRP levels. Furthermore, hs-CRP level is the only independent predictor of the presence of CAC.

Original languageEnglish
Pages (from-to)1119-1123
Number of pages5
JournalAmerican Journal of Cardiology
Volume100
Issue number7
DOIs
Publication statusPublished - Oct 1 2007

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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