Relation between fetuin-A levels and fibroblast growth factor 23 with the severity of coronary artery disease measured by SYNTAX scores

Yueh Chung Chen, Feng Yen Lin, Rong Ho Lin, Chun Ling Chuang, Chao Chien Chang, Chien Sung Tsai

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Diagnosis of coronary artery disease requires invasive procedures that are typically not implemented until clinical warning signs are apparent. The goal of this study was to determine the relation between the severity of coronary artery disease, as measured by the SYNTAX scoring system, with serum levels of fetuin-A and fibroblast growth factor 23 (FGF23) in the general population. We enrolled 165 patients who had stable angina and positive results on treadmill testing or abnormal results on thallium myocardial perfusion scanning showing perfusion defects or who had acute coronary syndromes. Patients were hospitalized for evaluation with angiography, with or without simultaneous percutaneous coronary intervention. SYNTAX Scores were calculated on the basis of the results of coronary angiography using a computer-based questionnaire of sequential and interactive self-guided questions. Univariate analysis was used to assess the significance of fetuin-A and FGF23, as well as gender, age, body mass index, waist circumference, diabetes, hypertension, creatinine, total cholesterol, cholesterol, triglycerides, and high-sensitivity C-reactive protein in relation to cardiovascular disease severity. Multivariate analysis with stepwise regression was used to assess the utility of fetuin-A and FGF23 as predictors of SYNTAX Score. Multivariate analysis showed log fetuin-A to be a significant predictor of SYNTAX Score (p

Original languageEnglish
Pages (from-to)950-953
Number of pages4
JournalAmerican Journal of Cardiology
Volume112
Issue number7
DOIs
Publication statusPublished - Oct 1 2013

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alpha-2-HS-Glycoprotein
Coronary Artery Disease
Multivariate Analysis
Perfusion
Cholesterol
Stable Angina
Thallium
Waist Circumference
Percutaneous Coronary Intervention
Acute Coronary Syndrome
Coronary Angiography
C-Reactive Protein
Creatinine
Angiography
Triglycerides
Body Mass Index
Cardiovascular Diseases
Hypertension
fibroblast growth factor 23
Serum

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Relation between fetuin-A levels and fibroblast growth factor 23 with the severity of coronary artery disease measured by SYNTAX scores. / Chen, Yueh Chung; Lin, Feng Yen; Lin, Rong Ho; Chuang, Chun Ling; Chang, Chao Chien; Tsai, Chien Sung.

In: American Journal of Cardiology, Vol. 112, No. 7, 01.10.2013, p. 950-953.

Research output: Contribution to journalArticle

Chen, Yueh Chung ; Lin, Feng Yen ; Lin, Rong Ho ; Chuang, Chun Ling ; Chang, Chao Chien ; Tsai, Chien Sung. / Relation between fetuin-A levels and fibroblast growth factor 23 with the severity of coronary artery disease measured by SYNTAX scores. In: American Journal of Cardiology. 2013 ; Vol. 112, No. 7. pp. 950-953.
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