Regulatory RNAs, microRNA, long-non coding RNA and circular RNA roles in colorectal cancer stem cells

Hsiao Mei Chao, Teh Wei Wang, Edward Chern, Shan Hui Hsu

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The properties of cancer stem cells (CSCs), such as self-renewal, drug resistance, and metastasis, have been indicated to be responsible for the poor prognosis of patients with colon cancers. The epigenetic regulatory network plays a crucial role in CSC properties. Regulatory non-coding RNA (ncRNA), including microRNAs, long noncoding RNAs, and circular RNAs, have an important influence on cell physiopathology. They modulate cells by regulating gene expression in different ways. This review discusses the basic characteristics and the physiological functions of colorectal cancer (CRC) stem cells. Elucidation of these ncRNAs will help us understand the pathological mechanism of CRC progression, and they could become a new target for cancer treatment.

Original languageEnglish
Pages (from-to)748-764
Number of pages17
JournalWorld Journal of Gastrointestinal Oncology
Volume14
Issue number4
DOIs
Publication statusPublished - Apr 15 2022

Keywords

  • Cancer stem cell
  • Circular rna
  • Colorectal cancer
  • Long-non coding rna
  • Microrna
  • Regulatory rnas
  • Stemness

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

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