Regulatory mechanisms of atrial fibrotic remodeling in atrial fibrillation

C. S. Lin, C. H. Pan

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Electrical, contractile and structural remodeling have been characterized in atrial fibrillation (AF), and the latter is considered to be the major contributor to AF persistence. Recent data show that interstitial fibrosis can predispose to atrial conduction impairment and AF induction. The interplay between cardiac matrix metalloproteinases (MMPs) and their endogenous inhibitors, tissue inhibitors of MMPs (TIMPs), is thought to be critical in atrial extracellular matrix (ECM) metabolism. At the molecular level, angiotensin II, transforming growth factor-β1, inflammation and oxidative stress are particularly important for ECM dysregulation and atrial fibrotic remodeling in AF. Therefore, we review recent advances in the understanding of the atrial fibrotic process, the major downstream components in this remodeling process, and the expression and regulation of MMPs and TIMPs. We also describe the activation of bioactive molecules in both clinical studies and animal models to modulate MMPs and TIMPs and their effects on atrial fibrosis in AF.

Original languageEnglish
Pages (from-to)1489-1508
Number of pages20
JournalCellular and Molecular Life Sciences
Volume65
Issue number10
DOIs
Publication statusPublished - May 2008
Externally publishedYes

Keywords

  • Angiotensin II
  • Atrial fibrillation
  • Atrial remodeling
  • Inflammation
  • Matrix metalloproteinases
  • Oxidative stress
  • Tissue inhibitors of matrix metalloproteinases
  • Transforming growth factor-β1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

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