Regulation of tumor growth and metastasis: the role of tumor microenvironment

Hadi Alphonse Goubran, Rami R Kotb, Julie Stakiw, Mohamed E Emara, Thierry Pierre Robert Burnouf

Research output: Contribution to journalArticle

Abstract

The presence of abnormal cells with malignant potential or neoplastic characteristics is a relatively common phenomenon. The interaction of these abnormal cells with their microenvironment is essential for tumor development, protection from the body's immune or defence mechanisms, later progression and the development of life-threatening or metastatic disease. The tumor microenvironment is a collective term that includes the tumor's surrounding and supportive stroma, the different effectors of the immune system, blood platelets, hormones and other humoral factors. A better understanding of the interplay between the tumor cells and its microenvironment can provide efficient tools for cancer management, as well as better prevention, screening and risk assessment protocols.

Original languageEnglish
Pages (from-to)9-18
Number of pages10
JournalCancer growth and metastasis
Volume7
DOIs
Publication statusPublished - 2014

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Tumor Microenvironment
Neoplasm Metastasis
Growth
Neoplasms
Cellular Microenvironment
Cell Communication
Immune System
Blood Platelets
Hormones

Keywords

  • Journal Article
  • Review

Cite this

Regulation of tumor growth and metastasis : the role of tumor microenvironment. / Goubran, Hadi Alphonse; Kotb, Rami R ; Stakiw, Julie; Emara, Mohamed E; Burnouf, Thierry Pierre Robert.

In: Cancer growth and metastasis, Vol. 7, 2014, p. 9-18.

Research output: Contribution to journalArticle

Goubran, Hadi Alphonse ; Kotb, Rami R ; Stakiw, Julie ; Emara, Mohamed E ; Burnouf, Thierry Pierre Robert. / Regulation of tumor growth and metastasis : the role of tumor microenvironment. In: Cancer growth and metastasis. 2014 ; Vol. 7. pp. 9-18.
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