Regulation of nuclear receptor activities by two human papillomavirus type 18 oncoproteins, E6 and E7

Wei Ming Wang, Min Huey Chung, Shih Ming Huang

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The human papillomavirus (HPV) E6 and E7 oncoproteins are two major proteins that remain expressing in HPV-associated human cancers. The high-risk HPVs synthesize E6 and E7 oncoproteins to alter the function of cellular regulatory proteins, such as p53 and retinoblastoma gene product, respectively. In this study, we demonstrated that HPV-18 E6 and E7 proteins were able to directly interact with some nuclear receptors (NRs), such as thyroid receptor, androgen receptor, and estrogen receptor (ER), whether or not appropriate hormones were present. The functional roles of these two oncoproteins in NRs depended on the cell type (including ligand), promoter context, and NR type. These two oncoproteins regulated ER functions through ER's AF-1, AF-2, or both. Hence, our results provide new insights into the mechanisms controlling the proliferation and immortalization of HPV infected cells by these two oncoproteins mediating through their regulatory functions in NR systems.

Original languageEnglish
Pages (from-to)932-939
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume303
Issue number3
DOIs
Publication statusPublished - Apr 11 2003
Externally publishedYes

    Fingerprint

Keywords

  • GRIP1
  • HPV oncoproteins
  • Nuclear receptor
  • p53
  • Transcription regulation

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this