Regression analysis between heart rate variability and baroreflex-related vagus nerve activity in rats

Terry B J Kuo, Ching J. Lai, Yu Ting Huang, Cheryl C H Yang

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Introduction: Many previous studies have suggested that the high-frequency (HF) power of the heart rate variability may represent cardiac vagal activity although direct evidence of a correlation between the HF and vagal neuronal activity is still lacking. In the present study, we performed a regression analysis of the HF and vagal neurograms. Methods and Results: Experiments were carried out on adult male Sprague-Dawley rats anesthetized with a continuous infusion of pentobarbital sodium. The baroreflex-related vagus neuronal activities were obtained by nerve or single-fiber recordings. The transient baroreflex response was employed to alter vagus neuronal activities using a bolus injection of phenylephrine (PE). On-line power spectral analysis of the heart rate and a vagal neurogram was performed during the acute baroreflex response. During the test period, systemic arterial pressure immediately increased in response to the PE injection, after which the R-R interval (RR), HF (0.6-2.4 Hz), and vagus nerve and unit activities all dramatically increased. Both nerve and unit activities exhibited good correlations (r ≥ 0.7 in all nerve recordings and r ≥ 0.6 in 91% of single-fiber recordings) with the HF. There were insignificant differences between the right- and left-side baroreflex-related vagus nerve recordings. Conclusion: Our present study provides a direct linkage between the HF and vagus neuronal electrical activity in anesthetized rats.

Original languageEnglish
Pages (from-to)864-869
Number of pages6
JournalJournal of Cardiovascular Electrophysiology
Volume16
Issue number8
DOIs
Publication statusPublished - Aug 2005
Externally publishedYes

Fingerprint

Vagus Nerve
Baroreflex
Heart Rate
Regression Analysis
Phenylephrine
Injections
Pentobarbital
Sprague Dawley Rats
Arterial Pressure

Keywords

  • Baroreflex
  • Heart rate variability
  • Power spectral analysis
  • Single-fiber recordings
  • Vagus nerve recordings

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Regression analysis between heart rate variability and baroreflex-related vagus nerve activity in rats. / Kuo, Terry B J; Lai, Ching J.; Huang, Yu Ting; Yang, Cheryl C H.

In: Journal of Cardiovascular Electrophysiology, Vol. 16, No. 8, 08.2005, p. 864-869.

Research output: Contribution to journalArticle

@article{376caec4b83943d69c5a117ccebe25fe,
title = "Regression analysis between heart rate variability and baroreflex-related vagus nerve activity in rats",
abstract = "Introduction: Many previous studies have suggested that the high-frequency (HF) power of the heart rate variability may represent cardiac vagal activity although direct evidence of a correlation between the HF and vagal neuronal activity is still lacking. In the present study, we performed a regression analysis of the HF and vagal neurograms. Methods and Results: Experiments were carried out on adult male Sprague-Dawley rats anesthetized with a continuous infusion of pentobarbital sodium. The baroreflex-related vagus neuronal activities were obtained by nerve or single-fiber recordings. The transient baroreflex response was employed to alter vagus neuronal activities using a bolus injection of phenylephrine (PE). On-line power spectral analysis of the heart rate and a vagal neurogram was performed during the acute baroreflex response. During the test period, systemic arterial pressure immediately increased in response to the PE injection, after which the R-R interval (RR), HF (0.6-2.4 Hz), and vagus nerve and unit activities all dramatically increased. Both nerve and unit activities exhibited good correlations (r ≥ 0.7 in all nerve recordings and r ≥ 0.6 in 91{\%} of single-fiber recordings) with the HF. There were insignificant differences between the right- and left-side baroreflex-related vagus nerve recordings. Conclusion: Our present study provides a direct linkage between the HF and vagus neuronal electrical activity in anesthetized rats.",
keywords = "Baroreflex, Heart rate variability, Power spectral analysis, Single-fiber recordings, Vagus nerve recordings",
author = "Kuo, {Terry B J} and Lai, {Ching J.} and Huang, {Yu Ting} and Yang, {Cheryl C H}",
year = "2005",
month = "8",
doi = "10.1111/j.1540-8167.2005.40656.x",
language = "English",
volume = "16",
pages = "864--869",
journal = "Journal of Cardiovascular Electrophysiology",
issn = "1045-3873",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Regression analysis between heart rate variability and baroreflex-related vagus nerve activity in rats

AU - Kuo, Terry B J

AU - Lai, Ching J.

AU - Huang, Yu Ting

AU - Yang, Cheryl C H

PY - 2005/8

Y1 - 2005/8

N2 - Introduction: Many previous studies have suggested that the high-frequency (HF) power of the heart rate variability may represent cardiac vagal activity although direct evidence of a correlation between the HF and vagal neuronal activity is still lacking. In the present study, we performed a regression analysis of the HF and vagal neurograms. Methods and Results: Experiments were carried out on adult male Sprague-Dawley rats anesthetized with a continuous infusion of pentobarbital sodium. The baroreflex-related vagus neuronal activities were obtained by nerve or single-fiber recordings. The transient baroreflex response was employed to alter vagus neuronal activities using a bolus injection of phenylephrine (PE). On-line power spectral analysis of the heart rate and a vagal neurogram was performed during the acute baroreflex response. During the test period, systemic arterial pressure immediately increased in response to the PE injection, after which the R-R interval (RR), HF (0.6-2.4 Hz), and vagus nerve and unit activities all dramatically increased. Both nerve and unit activities exhibited good correlations (r ≥ 0.7 in all nerve recordings and r ≥ 0.6 in 91% of single-fiber recordings) with the HF. There were insignificant differences between the right- and left-side baroreflex-related vagus nerve recordings. Conclusion: Our present study provides a direct linkage between the HF and vagus neuronal electrical activity in anesthetized rats.

AB - Introduction: Many previous studies have suggested that the high-frequency (HF) power of the heart rate variability may represent cardiac vagal activity although direct evidence of a correlation between the HF and vagal neuronal activity is still lacking. In the present study, we performed a regression analysis of the HF and vagal neurograms. Methods and Results: Experiments were carried out on adult male Sprague-Dawley rats anesthetized with a continuous infusion of pentobarbital sodium. The baroreflex-related vagus neuronal activities were obtained by nerve or single-fiber recordings. The transient baroreflex response was employed to alter vagus neuronal activities using a bolus injection of phenylephrine (PE). On-line power spectral analysis of the heart rate and a vagal neurogram was performed during the acute baroreflex response. During the test period, systemic arterial pressure immediately increased in response to the PE injection, after which the R-R interval (RR), HF (0.6-2.4 Hz), and vagus nerve and unit activities all dramatically increased. Both nerve and unit activities exhibited good correlations (r ≥ 0.7 in all nerve recordings and r ≥ 0.6 in 91% of single-fiber recordings) with the HF. There were insignificant differences between the right- and left-side baroreflex-related vagus nerve recordings. Conclusion: Our present study provides a direct linkage between the HF and vagus neuronal electrical activity in anesthetized rats.

KW - Baroreflex

KW - Heart rate variability

KW - Power spectral analysis

KW - Single-fiber recordings

KW - Vagus nerve recordings

UR - http://www.scopus.com/inward/record.url?scp=27744588371&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27744588371&partnerID=8YFLogxK

U2 - 10.1111/j.1540-8167.2005.40656.x

DO - 10.1111/j.1540-8167.2005.40656.x

M3 - Article

C2 - 16101628

AN - SCOPUS:27744588371

VL - 16

SP - 864

EP - 869

JO - Journal of Cardiovascular Electrophysiology

JF - Journal of Cardiovascular Electrophysiology

SN - 1045-3873

IS - 8

ER -