Regional diversities in fibrogenesisweighed as a key determinant for a trial arrhythmogenesis

Cheng Chih Chung, Chye Gen Chin, Yung Kuo Lin, Yao Chang Chen, Wan Li Cheng, Yung Hsin Yeh, Yu Hsun Kao, Yi Jen Chen

Research output: Contribution to journalReview articlepeer-review


Atrial fibrosis plays a key role in atrial myopathy, resulting in the genesis of atrial fibrillation (AF). The abnormal distribution of fibrotic tissue, electrical coupling, paracrine interactions, and biomechanical-electrical interactions have all been suggested as causes of fibrosis-related arrhythmogenesis. Moreover, the regional difference in fibrogenesis, specifically the left atrium (LA) exhibiting a higher arrhythmogenesis and level of fibrosis than the right atrium (RA) in AF, is a key contributor to atrial arrhythmogenesis. LA fibroblasts have greater profibrotic cellular activities than RA fibroblasts, but knowledge about the regional diversity of atrial regional fibrogenesis remains limited. This article provides a comprehensive review of research findings on the association between fibrogenesis and arrhythmogenesis from laboratory to clinical evidence and updates the current understanding of the potential mechanism underlying the difference in fibrogenesis between the LA and RA.

Original languageEnglish
Article number1900
Issue number12
Publication statusPublished - Dec 2021


  • Atrial fibrillation
  • Ca2+
  • Fibroblasts
  • Fibrosis
  • Heart failure
  • Left atrium
  • Nitric oxide
  • Oxidative stress
  • Right atrium
  • Transforming growth factor

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)


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