Abstract

Aims: Reflux esophagitis (RE) is a common disease which has been recognized to be associated with several medical co-morbidities. However, the association between RE and bladder pain syndrome/interstitial cystitis (BPS/IC) is still unknown. The present study aimed to explore the association between these two diseases. Methods: We identified 8,962 female patients who had received a diagnosis of RE as the study cohort. We randomly selected 44,810 subjects to be included as the comparison cohort. Each patient in this study was individually tracked for a 3-year period to identify those who subsequently received a diagnosis of BPS/IC. Cox proportional hazards regressions were carried out to estimate the 3-year risk of BPS/IC following a diagnosis of RE. Results: The incidence of BPS/IC following a diagnosis of RE was 4.3% during the follow-up period for all subjects. The incidence rate of BPS/IC was 2.38 [95% confidence interval (CI): 2.21-2.57] per 100 person-years in patients with RE, and 1.24 (95% CI: 1.18-1.30) per 100 person-years in controls. Cox proportional analysis indicated that the hazard ratio (HR) of BPS/IC for patients with RE was 2.00 (95% CI = 1.82-2.20, P <0.001) that of controls. The adjusted HR of BPS/IC for patients with RE was 1.40 (95% CI = 1.27-1.55, P <0.001) after taking age group, urbanization level, and medical comorbidity into consideration. Conclusion: We found that patients with RE were at a higher risk than with comparison patients for having been subsequently diagnosed with BPS/IC during longitudinal follow-up.

Original languageEnglish
Pages (from-to)271-275
Number of pages5
JournalNeurourology and Urodynamics
Volume32
Issue number3
DOIs
Publication statusPublished - Mar 2013

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Interstitial Cystitis
Peptic Esophagitis
Urinary Bladder
Pain
Confidence Intervals
Urbanization
Incidence
Comorbidity
Cohort Studies
Age Groups
Morbidity

Keywords

  • bladder pain syndrome/interstitial cystitis
  • interstitial cystitis
  • reflux esophagitis

ASJC Scopus subject areas

  • Clinical Neurology
  • Urology

Cite this

Reflux esophagitis increased the risk of bladder pain syndrome/interstitial cystitis : A 3-year follow-up study. / Kang, Jiunn Horng; Keller, Joseph J.; Chen, Yi Kuang; Lin, Herng Ching.

In: Neurourology and Urodynamics, Vol. 32, No. 3, 03.2013, p. 271-275.

Research output: Contribution to journalArticle

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title = "Reflux esophagitis increased the risk of bladder pain syndrome/interstitial cystitis: A 3-year follow-up study",
abstract = "Aims: Reflux esophagitis (RE) is a common disease which has been recognized to be associated with several medical co-morbidities. However, the association between RE and bladder pain syndrome/interstitial cystitis (BPS/IC) is still unknown. The present study aimed to explore the association between these two diseases. Methods: We identified 8,962 female patients who had received a diagnosis of RE as the study cohort. We randomly selected 44,810 subjects to be included as the comparison cohort. Each patient in this study was individually tracked for a 3-year period to identify those who subsequently received a diagnosis of BPS/IC. Cox proportional hazards regressions were carried out to estimate the 3-year risk of BPS/IC following a diagnosis of RE. Results: The incidence of BPS/IC following a diagnosis of RE was 4.3{\%} during the follow-up period for all subjects. The incidence rate of BPS/IC was 2.38 [95{\%} confidence interval (CI): 2.21-2.57] per 100 person-years in patients with RE, and 1.24 (95{\%} CI: 1.18-1.30) per 100 person-years in controls. Cox proportional analysis indicated that the hazard ratio (HR) of BPS/IC for patients with RE was 2.00 (95{\%} CI = 1.82-2.20, P <0.001) that of controls. The adjusted HR of BPS/IC for patients with RE was 1.40 (95{\%} CI = 1.27-1.55, P <0.001) after taking age group, urbanization level, and medical comorbidity into consideration. Conclusion: We found that patients with RE were at a higher risk than with comparison patients for having been subsequently diagnosed with BPS/IC during longitudinal follow-up.",
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T2 - A 3-year follow-up study

AU - Kang, Jiunn Horng

AU - Keller, Joseph J.

AU - Chen, Yi Kuang

AU - Lin, Herng Ching

PY - 2013/3

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N2 - Aims: Reflux esophagitis (RE) is a common disease which has been recognized to be associated with several medical co-morbidities. However, the association between RE and bladder pain syndrome/interstitial cystitis (BPS/IC) is still unknown. The present study aimed to explore the association between these two diseases. Methods: We identified 8,962 female patients who had received a diagnosis of RE as the study cohort. We randomly selected 44,810 subjects to be included as the comparison cohort. Each patient in this study was individually tracked for a 3-year period to identify those who subsequently received a diagnosis of BPS/IC. Cox proportional hazards regressions were carried out to estimate the 3-year risk of BPS/IC following a diagnosis of RE. Results: The incidence of BPS/IC following a diagnosis of RE was 4.3% during the follow-up period for all subjects. The incidence rate of BPS/IC was 2.38 [95% confidence interval (CI): 2.21-2.57] per 100 person-years in patients with RE, and 1.24 (95% CI: 1.18-1.30) per 100 person-years in controls. Cox proportional analysis indicated that the hazard ratio (HR) of BPS/IC for patients with RE was 2.00 (95% CI = 1.82-2.20, P <0.001) that of controls. The adjusted HR of BPS/IC for patients with RE was 1.40 (95% CI = 1.27-1.55, P <0.001) after taking age group, urbanization level, and medical comorbidity into consideration. Conclusion: We found that patients with RE were at a higher risk than with comparison patients for having been subsequently diagnosed with BPS/IC during longitudinal follow-up.

AB - Aims: Reflux esophagitis (RE) is a common disease which has been recognized to be associated with several medical co-morbidities. However, the association between RE and bladder pain syndrome/interstitial cystitis (BPS/IC) is still unknown. The present study aimed to explore the association between these two diseases. Methods: We identified 8,962 female patients who had received a diagnosis of RE as the study cohort. We randomly selected 44,810 subjects to be included as the comparison cohort. Each patient in this study was individually tracked for a 3-year period to identify those who subsequently received a diagnosis of BPS/IC. Cox proportional hazards regressions were carried out to estimate the 3-year risk of BPS/IC following a diagnosis of RE. Results: The incidence of BPS/IC following a diagnosis of RE was 4.3% during the follow-up period for all subjects. The incidence rate of BPS/IC was 2.38 [95% confidence interval (CI): 2.21-2.57] per 100 person-years in patients with RE, and 1.24 (95% CI: 1.18-1.30) per 100 person-years in controls. Cox proportional analysis indicated that the hazard ratio (HR) of BPS/IC for patients with RE was 2.00 (95% CI = 1.82-2.20, P <0.001) that of controls. The adjusted HR of BPS/IC for patients with RE was 1.40 (95% CI = 1.27-1.55, P <0.001) after taking age group, urbanization level, and medical comorbidity into consideration. Conclusion: We found that patients with RE were at a higher risk than with comparison patients for having been subsequently diagnosed with BPS/IC during longitudinal follow-up.

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