Reemergence of Enterovirus 71 epidemic in Northern Taiwan, 2012

Shu Ting Luo, Pai Shan Chiang, Wan Yu Chung, Min Yuan Chia, Kuo Chien Tsao, Ying Hsiang Wang, Tzou Yien Lin, Min Shi Lee

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Enterovirus 71 (EV71) belongs to picornavirus family and could be classified phylogenetically into three major genogroups (A, B and C) including 11 genotypes (A, B1-B5 and C1-C5). Since 1997, EV71 has caused large-scale of epidemics with neurological complications in Asian children. In Taiwan, nationwide EV71 epidemics with different predominant genotypes have occurred cyclically since 1998. A nationwide EV71 epidemic occurred again in 2012. We conducted genetic and antigenic characterizations of the 2012 epidemic. Methods Chang Gung Memorial Hospital (CGMH) is a medical center in northern Taiwan. In CGMH, specimens were collected from pediatric inpatients with suspected enterovirus infections for virus isolation. Enterovirus isolates were serotyped and genotyped and sera from EV71 inpatients were collected for measuring neutralizing antibody titers. Results There were 10, 16 and 99 EV71 inpatients identified in 2010, 2011 and 2012, respectively. There were 82 EV71 isolates genotyped, which identified 17 genotype C4a viruses and 65 genotype B5 viruses. The genotype B5 viruses were not detected until November 2011 and caused epidemics in 2012. Interestingly, the B5-2011 viruses were genetically distinguishable from the B5 viruses causing the 2008 epidemic and are likely introduced from China or Southeastern Asia. Based on antigenic analysis, minor antigenic variations were detected among the B5-2008, B5-2011, C4a-2008 and C4a-2012 viruses but these viruses antigenically differed from genotype A.Conclusions Genotype B5 and C4a viruses antigenically differ from genotype A viruses which have disappeared globally for 30 years but have been detected in China since 2008. Enterovirus surveillance should monitor genetic and antigenic variations of EV71.

Original languageEnglish
Article numbere0116322
JournalPLoS One
Volume10
Issue number3
DOIs
Publication statusPublished - Mar 16 2015
Externally publishedYes

Fingerprint

Enterovirus
Taiwan
Viruses
Genotype
viruses
genotype
Inpatients
Antigenic Variation
antigenic variation
China
Enterovirus Infections
Picornaviridae
Southeastern Asia
Pediatrics
monitoring
Neutralizing Antibodies
neutralizing antibodies

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Luo, S. T., Chiang, P. S., Chung, W. Y., Chia, M. Y., Tsao, K. C., Wang, Y. H., ... Lee, M. S. (2015). Reemergence of Enterovirus 71 epidemic in Northern Taiwan, 2012. PLoS One, 10(3), [e0116322]. https://doi.org/10.1371/journal.pone.0116322

Reemergence of Enterovirus 71 epidemic in Northern Taiwan, 2012. / Luo, Shu Ting; Chiang, Pai Shan; Chung, Wan Yu; Chia, Min Yuan; Tsao, Kuo Chien; Wang, Ying Hsiang; Lin, Tzou Yien; Lee, Min Shi.

In: PLoS One, Vol. 10, No. 3, e0116322, 16.03.2015.

Research output: Contribution to journalArticle

Luo, ST, Chiang, PS, Chung, WY, Chia, MY, Tsao, KC, Wang, YH, Lin, TY & Lee, MS 2015, 'Reemergence of Enterovirus 71 epidemic in Northern Taiwan, 2012', PLoS One, vol. 10, no. 3, e0116322. https://doi.org/10.1371/journal.pone.0116322
Luo ST, Chiang PS, Chung WY, Chia MY, Tsao KC, Wang YH et al. Reemergence of Enterovirus 71 epidemic in Northern Taiwan, 2012. PLoS One. 2015 Mar 16;10(3). e0116322. https://doi.org/10.1371/journal.pone.0116322
Luo, Shu Ting ; Chiang, Pai Shan ; Chung, Wan Yu ; Chia, Min Yuan ; Tsao, Kuo Chien ; Wang, Ying Hsiang ; Lin, Tzou Yien ; Lee, Min Shi. / Reemergence of Enterovirus 71 epidemic in Northern Taiwan, 2012. In: PLoS One. 2015 ; Vol. 10, No. 3.
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