Reduced Sympathetic Skin Response in the Isolated Spinal Cord of Subjects With Spinal Cord Injury

Shin Liang Pan, Yen Ho Wang, Wen Hsuan Hou, Chao Min Wang, Tien Shang Huang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Pan S-L, Wang Y-H, Hou W-H, Wang C-M, Huang T-S. Reduced sympathetic skin response in the isolated spinal cord of subjects with spinal cord injury. Objective: To compare the excitability of the sympathetic skin response (SSR) between subjects with spinal cord injury (SCI) and healthy controls with intact supraspinal connection. Design: Cross-sectional survey. Setting: Referral center. Participants: A total of 37 men with traumatic neurologically complete SCI (26 with tetraplegia, 11 with paraplegia) and history of autonomic dysreflexia were included. Twenty age-matched healthy male controls were recruited as the control group. Subjects with SCI were at the mean age ± standard deviation of 36.5±11.0 years (range, 20.1-61.3y) and the mean injury duration was 11.3±9.3 years (range, 1.0-38.1y). Interventions: Not applicable. Main Outcome Measures: The SSR tests were grouped into 3 test sets according the stimulation and recording sites: (1) right supraorbital nerve stimulation with left hand recording (SH set); (2) right supraorbital nerve stimulation and left foot recording (SF set); and (3) right posterior tibial nerve stimulation and left foot recording (TF set). Results: In patients with tetraplegia (n=26), none showed positive SSR in the SH or the SF set, and only 5 (19.2%) showed a positive SSR in the TF set. In subjects with paraplegia (n=11), the positive response rates of SSR were 72.7% for the SH set, 0% for the SF set, and 9.1% for the TF set. Electric stimulation at high intensity (100mA for 1ms) was required to elicit SSR for the TF set in the patients with SCI. The SSR amplitudes in the SH and TF sets were smaller in subjects with SCI than those in controls (SH set, P=.004; TF set, P

Original languageEnglish
Pages (from-to)1201-1206
Number of pages6
JournalArchives of Physical Medicine and Rehabilitation
Volume87
Issue number9
DOIs
Publication statusPublished - Sep 2006
Externally publishedYes

Fingerprint

Spinal Cord Injuries
Spinal Cord
Skin
Quadriplegia
Paraplegia
Foot
Autonomic Dysreflexia
Tibial Nerve
Skin Tests
Electric Stimulation
Referral and Consultation
Hand
Cross-Sectional Studies
Outcome Assessment (Health Care)
Control Groups
Wounds and Injuries

Keywords

  • Autonomic dysreflexia
  • Autonomic nervous system
  • Electric stimulation
  • Rehabilitation
  • Spinal cord injuries

ASJC Scopus subject areas

  • Rehabilitation

Cite this

Reduced Sympathetic Skin Response in the Isolated Spinal Cord of Subjects With Spinal Cord Injury. / Pan, Shin Liang; Wang, Yen Ho; Hou, Wen Hsuan; Wang, Chao Min; Huang, Tien Shang.

In: Archives of Physical Medicine and Rehabilitation, Vol. 87, No. 9, 09.2006, p. 1201-1206.

Research output: Contribution to journalArticle

Pan, Shin Liang ; Wang, Yen Ho ; Hou, Wen Hsuan ; Wang, Chao Min ; Huang, Tien Shang. / Reduced Sympathetic Skin Response in the Isolated Spinal Cord of Subjects With Spinal Cord Injury. In: Archives of Physical Medicine and Rehabilitation. 2006 ; Vol. 87, No. 9. pp. 1201-1206.
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abstract = "Pan S-L, Wang Y-H, Hou W-H, Wang C-M, Huang T-S. Reduced sympathetic skin response in the isolated spinal cord of subjects with spinal cord injury. Objective: To compare the excitability of the sympathetic skin response (SSR) between subjects with spinal cord injury (SCI) and healthy controls with intact supraspinal connection. Design: Cross-sectional survey. Setting: Referral center. Participants: A total of 37 men with traumatic neurologically complete SCI (26 with tetraplegia, 11 with paraplegia) and history of autonomic dysreflexia were included. Twenty age-matched healthy male controls were recruited as the control group. Subjects with SCI were at the mean age ± standard deviation of 36.5±11.0 years (range, 20.1-61.3y) and the mean injury duration was 11.3±9.3 years (range, 1.0-38.1y). Interventions: Not applicable. Main Outcome Measures: The SSR tests were grouped into 3 test sets according the stimulation and recording sites: (1) right supraorbital nerve stimulation with left hand recording (SH set); (2) right supraorbital nerve stimulation and left foot recording (SF set); and (3) right posterior tibial nerve stimulation and left foot recording (TF set). Results: In patients with tetraplegia (n=26), none showed positive SSR in the SH or the SF set, and only 5 (19.2{\%}) showed a positive SSR in the TF set. In subjects with paraplegia (n=11), the positive response rates of SSR were 72.7{\%} for the SH set, 0{\%} for the SF set, and 9.1{\%} for the TF set. Electric stimulation at high intensity (100mA for 1ms) was required to elicit SSR for the TF set in the patients with SCI. The SSR amplitudes in the SH and TF sets were smaller in subjects with SCI than those in controls (SH set, P=.004; TF set, P",
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AB - Pan S-L, Wang Y-H, Hou W-H, Wang C-M, Huang T-S. Reduced sympathetic skin response in the isolated spinal cord of subjects with spinal cord injury. Objective: To compare the excitability of the sympathetic skin response (SSR) between subjects with spinal cord injury (SCI) and healthy controls with intact supraspinal connection. Design: Cross-sectional survey. Setting: Referral center. Participants: A total of 37 men with traumatic neurologically complete SCI (26 with tetraplegia, 11 with paraplegia) and history of autonomic dysreflexia were included. Twenty age-matched healthy male controls were recruited as the control group. Subjects with SCI were at the mean age ± standard deviation of 36.5±11.0 years (range, 20.1-61.3y) and the mean injury duration was 11.3±9.3 years (range, 1.0-38.1y). Interventions: Not applicable. Main Outcome Measures: The SSR tests were grouped into 3 test sets according the stimulation and recording sites: (1) right supraorbital nerve stimulation with left hand recording (SH set); (2) right supraorbital nerve stimulation and left foot recording (SF set); and (3) right posterior tibial nerve stimulation and left foot recording (TF set). Results: In patients with tetraplegia (n=26), none showed positive SSR in the SH or the SF set, and only 5 (19.2%) showed a positive SSR in the TF set. In subjects with paraplegia (n=11), the positive response rates of SSR were 72.7% for the SH set, 0% for the SF set, and 9.1% for the TF set. Electric stimulation at high intensity (100mA for 1ms) was required to elicit SSR for the TF set in the patients with SCI. The SSR amplitudes in the SH and TF sets were smaller in subjects with SCI than those in controls (SH set, P=.004; TF set, P

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