Reduced resting-state functional connectivity of the somatosensory cortex predicts psychopathological symptoms in women with bulimia nervosa

Luca Lavagnino, Federico Amianto, Federico D'Agata, Zirui Huang, Paolo Mortara, Giovanni Abbate-Daga, Enrica Marzola, Angela Spalatro, Secondo Fassino, Georg Franz Josef Northoff

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Alterations in the resting-state functional connectivity (rs-FC) of several brain networks have been demonstrated in eating disorders. However, very few studies are currently available on brain network dysfunctions in bulimia nervosa (BN).The somatosensory network is central in processing body-related stimuli and it may be altered in BN. The present study therefore aimed to investigate rs-FC in the somatosensory network in bulimic women. Methods: Sixteen medication-free women with BN (age = 23 ± 5 years) and 18 matched controls (age = 23 ± 3 years) underwent a functional magnetic resonance resting-state scan and assessment of eating disorder symptoms. Within-network and seed-based functional connectivity analyses were conducted to assess rs-FC within the somatosensory network and to other areas of the brain. Results: Bulimia nervosa patients showed a decreased rs-FC both within the somatosensory network (t = 9.0, df = 1, P = 0.005) and with posterior cingulate cortex and two visual areas (the right middle occipital gyrus and the right cuneus) (P = 0.05 corrected for multiple comparison). The rs-FC of the left paracentral lobule with the right middle occipital gyrus correlated with psychopathology measures like bulimia (r = -0.4; P = 0.02) and interoceptive awareness (r = -0.4; P = 0.01). Analyses were conducted using age, BMI (body mass index), and depressive symptoms as covariates. Conclusion: Our findings show a specific alteration of the rs-FC of the somatosensory cortex in BN patients, which correlates with eating disorder symptoms. The region in the right middle occipital gyrus is implicated in body processing and is known as extrastriate body area (EBA). The connectivity between the somatosensory cortex and the EBA might be related to dysfunctions in body image processing. The results should be considered preliminary due to the small sample size. © 2014 Lavagnino, Amianto, D'Agata, Huang, Mortara, Abbate-Daga, Marzola, Spalatro, Fassino and Northoff.
Original languageEnglish
JournalFrontiers in Behavioral Neuroscience
Volume8
Issue numberAUG
DOIs
Publication statusPublished - 2014

Fingerprint

Bulimia Nervosa
Somatosensory Cortex
Occipital Lobe
Brain
Bulimia
Body Image
Gyrus Cinguli
Psychopathology
Sample Size
Seeds
Body Mass Index
Magnetic Resonance Spectroscopy
Depression
Feeding and Eating Disorders

Keywords

  • Bulimia
  • Eating disorders
  • fMRI
  • Functional connectivity
  • Resting state
  • Somatosensory network
  • adult
  • age
  • article
  • awareness
  • body mass
  • bulimia
  • clinical article
  • controlled study
  • cuneus
  • depression
  • female
  • functional magnetic resonance imaging
  • human
  • mental disease
  • occipital gyrus
  • posterior cingulate
  • prediction
  • resting state functional connectivity
  • resting state network
  • somatosensory cortex
  • symptomatology
  • visual cortex

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Reduced resting-state functional connectivity of the somatosensory cortex predicts psychopathological symptoms in women with bulimia nervosa. / Lavagnino, Luca; Amianto, Federico; D'Agata, Federico; Huang, Zirui; Mortara, Paolo; Abbate-Daga, Giovanni; Marzola, Enrica; Spalatro, Angela; Fassino, Secondo; Northoff, Georg Franz Josef.

In: Frontiers in Behavioral Neuroscience, Vol. 8, No. AUG, 2014.

Research output: Contribution to journalArticle

Lavagnino, Luca ; Amianto, Federico ; D'Agata, Federico ; Huang, Zirui ; Mortara, Paolo ; Abbate-Daga, Giovanni ; Marzola, Enrica ; Spalatro, Angela ; Fassino, Secondo ; Northoff, Georg Franz Josef. / Reduced resting-state functional connectivity of the somatosensory cortex predicts psychopathological symptoms in women with bulimia nervosa. In: Frontiers in Behavioral Neuroscience. 2014 ; Vol. 8, No. AUG.
@article{0617001c02744273a33a9f09d2186433,
title = "Reduced resting-state functional connectivity of the somatosensory cortex predicts psychopathological symptoms in women with bulimia nervosa",
abstract = "Background: Alterations in the resting-state functional connectivity (rs-FC) of several brain networks have been demonstrated in eating disorders. However, very few studies are currently available on brain network dysfunctions in bulimia nervosa (BN).The somatosensory network is central in processing body-related stimuli and it may be altered in BN. The present study therefore aimed to investigate rs-FC in the somatosensory network in bulimic women. Methods: Sixteen medication-free women with BN (age = 23 ± 5 years) and 18 matched controls (age = 23 ± 3 years) underwent a functional magnetic resonance resting-state scan and assessment of eating disorder symptoms. Within-network and seed-based functional connectivity analyses were conducted to assess rs-FC within the somatosensory network and to other areas of the brain. Results: Bulimia nervosa patients showed a decreased rs-FC both within the somatosensory network (t = 9.0, df = 1, P = 0.005) and with posterior cingulate cortex and two visual areas (the right middle occipital gyrus and the right cuneus) (P = 0.05 corrected for multiple comparison). The rs-FC of the left paracentral lobule with the right middle occipital gyrus correlated with psychopathology measures like bulimia (r = -0.4; P = 0.02) and interoceptive awareness (r = -0.4; P = 0.01). Analyses were conducted using age, BMI (body mass index), and depressive symptoms as covariates. Conclusion: Our findings show a specific alteration of the rs-FC of the somatosensory cortex in BN patients, which correlates with eating disorder symptoms. The region in the right middle occipital gyrus is implicated in body processing and is known as extrastriate body area (EBA). The connectivity between the somatosensory cortex and the EBA might be related to dysfunctions in body image processing. The results should be considered preliminary due to the small sample size. {\circledC} 2014 Lavagnino, Amianto, D'Agata, Huang, Mortara, Abbate-Daga, Marzola, Spalatro, Fassino and Northoff.",
keywords = "Bulimia, Eating disorders, fMRI, Functional connectivity, Resting state, Somatosensory network, adult, age, article, awareness, body mass, bulimia, clinical article, controlled study, cuneus, depression, female, functional magnetic resonance imaging, human, mental disease, occipital gyrus, posterior cingulate, prediction, resting state functional connectivity, resting state network, somatosensory cortex, symptomatology, visual cortex",
author = "Luca Lavagnino and Federico Amianto and Federico D'Agata and Zirui Huang and Paolo Mortara and Giovanni Abbate-Daga and Enrica Marzola and Angela Spalatro and Secondo Fassino and Northoff, {Georg Franz Josef}",
note = "Cited By :3 Export Date: 11 May 2016 Correspondence Address: Lavagnino, L.; Department of Neuroscience, AOU San Giovanni Battista, Turin, Italy; email: luca.lavagnino77@gmail.com References: Abbate-Daga, G., Gramaglia, C., Amianto, F., Marzola, E., Fassino, F., Attachment insecurity, personality, and body dissatisfaction in eating disorders (2010) J. Nerv. Ment. Dis., 198, pp. 520-524. , doi: 10. 1097/NMD. 0b013e3181e4c6f7; (2000) Diagnostic and Statistical Manual of Mental Disorders, , 4th Edition, Text Revision (DSM-IV-TR). Washington, DC: American Psychiatric Association, American Psychiatric Association; Amianto, F., Caroppo, P., D'Agata, F., Spalatro, A., Lavagnino, L., Caglio, M., Brain volumetric abnormalities in patients with anorexia and bulimia nervosa: A voxel-based morphometry study (2013) Psychiatry Res., 213, pp. 210-216. , doi:10. 1016/j. pscychresns. 2013. 03. 010; Amianto, F., D'Agata, F., Lavagnino, L., Caroppo, P., Abbate-Daga, G., Righi, D., Intrinsic connectivity networks within cerebellum and beyond in eating disorders (2013) Cerebellum, 12, pp. 623-631. , doi:10. 1007/s12311-013-0471-1; Biswal, B., Fetkin, F.Z., Haughton, V.M., Hyde, J.S., Functional connectivity in the motor cortex of resting human brain using echo-planar MRI (1995) Magn. Reson. Med., 34, pp. 537-541. , doi:10. 1002/mrm. 1910340409; Bohon, C., Stice, E., Burton, E., Maintenance factors for persistence of bulimic pathology: A prospective natural history study (2009) Int. J. Eat. Disord., 42, pp. 173-178. , doi:10. 1002/eat. 20600; Case, L.K., Wilson, R.C., Ramachandran, V.S., Diminished size-weight illusion in anorexia nervosa: Evidence for visuo-proprioceptive integration deficit (2012) Exp. Brain Res., 217, pp. 79-87. , doi:10. 1007/s00221-011-2974-7; Cazzato, V., Mele, S., Urgesi, C., Gender differences in the neural underpinning of perceiving and appreciating the beauty of the body (2014) Behav. Brain Res., 264, pp. 188-196. , doi:10. 1016/j. bbr. 2014. 02. 001; Cowdrey, F.A., Filippini, N., Park, R.J., Smith, S.M., McCabe, C., Increased resting state functional connectivity in the default mode network in recovered anorexia nervosa (2014) Hum. Brain Mapp., 35, pp. 483-491. , doi:10. 1002/hbm. 22202; Cox, R.W., AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages (1996) Comput Biomed. Res., 29, pp. 162-173. , doi:10. 1006/cbmr. 1996. 0014; Curtis, C.E., D'Esposito, M., Persistent activity in the prefrontal cortex during working memory (2003) Trends Cogn. Sci., 7, pp. 415-423. , doi:10. 1016/S1364-6613(03)00197-9; Downing, P.E., Jiang, Y., Shuman, M., Kanwisher, N., A cortical area selective for visual processing of the human body (2001) Science, 293, pp. 2470-2473. , doi:10. 1126/science. 1063414; Eddy, K.T., Rauch, S.L., Neuroimaging in eating disorders: Coming of age (2011) Am. J. Psychiatry, 168, pp. 1139-1141. , doi:10. 1176/appi. ajp. 2011. 11071125; Eickhoff, S.B., Stephan, K.E., Mohlberg, H., Grefkes, C., Fink, G.R., Amunts, K., A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data (2005) Neuroimage, 25, pp. 1325-1335. , doi:10. 1016/j. neuroimage. 2004. 12. 034; Fairburn, C.G., Harrison, P.J., Eating disorders (2013) Lancet, 361, pp. 407-416. , doi:10. 1016/S0140-6736(03)12378-1; Fassino, S., Abbate-Daga, G., Resistance to treatment in eating disorders: A critical challenge (2013) BMC Psychiatry, 13, p. 282. , doi:10. 1186/1471-244X-13-282; Fassino, S., Pier{\`o}, A., Gramaglia, C., Abbate-Daga, G., Clinical, psychopathological and personality correlates of interoceptive awareness in anorexia nervosa, bulimia nervosa and obesity (2004) Psychopathology, 37, pp. 168-174. , doi:10. 1159/000079420; Favaro, A., Santonastaso, P., Manara, R., Bosello, R., Bommarito, G., Tenconi, E., Disruption of visuospatial and somatosensory functional connectivity in anorexia nervosa (2012) Biol. Psychiatry, 72, pp. 864-870. , doi:10. 1016/j. biopsych. 2012. 04. 025; Fox, M.D., Raichle, M.E., Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging (2007) Nat. Rev. Neurosci., 8, pp. 700-711. , doi:10. 1038/nrn2201; Fox, M.D., Snyder, A.Z., Vincent, J.L., Corbetta, M., Van Essen, D.C., Raichle, M.E., The human brain is intrinsically organized into dynamic, anticorrelated functional networks (2005) Proc. Natl. Acad. Sci. U. S. A, 102, pp. 9673-9678. , doi:10. 1073/pnas. 0504136102; Frank, G.K., Advances in the diagnosis of anorexia nervosa and bulimia nervosa using brain imaging (2012) Expert Opin. Med. Diagn., 6, pp. 235-244. , doi:10. 1517/17530059. 2012. 673583; Frank, G.K., Shott, M.E., Hagman, J.O., Mittal, V.A., Alterations in brains structures related to taste reward circuitry in ill and recovered anorexia nervosa and in bulimia nervosa (2013) Am. J. 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language = "English",
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issn = "1662-5153",
publisher = "Frontiers Research Foundation",
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}

TY - JOUR

T1 - Reduced resting-state functional connectivity of the somatosensory cortex predicts psychopathological symptoms in women with bulimia nervosa

AU - Lavagnino, Luca

AU - Amianto, Federico

AU - D'Agata, Federico

AU - Huang, Zirui

AU - Mortara, Paolo

AU - Abbate-Daga, Giovanni

AU - Marzola, Enrica

AU - Spalatro, Angela

AU - Fassino, Secondo

AU - Northoff, Georg Franz Josef

N1 - Cited By :3 Export Date: 11 May 2016 Correspondence Address: Lavagnino, L.; Department of Neuroscience, AOU San Giovanni Battista, Turin, Italy; email: luca.lavagnino77@gmail.com References: Abbate-Daga, G., Gramaglia, C., Amianto, F., Marzola, E., Fassino, F., Attachment insecurity, personality, and body dissatisfaction in eating disorders (2010) J. Nerv. Ment. Dis., 198, pp. 520-524. , doi: 10. 1097/NMD. 0b013e3181e4c6f7; (2000) Diagnostic and Statistical Manual of Mental Disorders, , 4th Edition, Text Revision (DSM-IV-TR). Washington, DC: American Psychiatric Association, American Psychiatric Association; Amianto, F., Caroppo, P., D'Agata, F., Spalatro, A., Lavagnino, L., Caglio, M., Brain volumetric abnormalities in patients with anorexia and bulimia nervosa: A voxel-based morphometry study (2013) Psychiatry Res., 213, pp. 210-216. , doi:10. 1016/j. pscychresns. 2013. 03. 010; Amianto, F., D'Agata, F., Lavagnino, L., Caroppo, P., Abbate-Daga, G., Righi, D., Intrinsic connectivity networks within cerebellum and beyond in eating disorders (2013) Cerebellum, 12, pp. 623-631. , doi:10. 1007/s12311-013-0471-1; Biswal, B., Fetkin, F.Z., Haughton, V.M., Hyde, J.S., Functional connectivity in the motor cortex of resting human brain using echo-planar MRI (1995) Magn. Reson. Med., 34, pp. 537-541. , doi:10. 1002/mrm. 1910340409; Bohon, C., Stice, E., Burton, E., Maintenance factors for persistence of bulimic pathology: A prospective natural history study (2009) Int. J. Eat. Disord., 42, pp. 173-178. , doi:10. 1002/eat. 20600; Case, L.K., Wilson, R.C., Ramachandran, V.S., Diminished size-weight illusion in anorexia nervosa: Evidence for visuo-proprioceptive integration deficit (2012) Exp. Brain Res., 217, pp. 79-87. , doi:10. 1007/s00221-011-2974-7; Cazzato, V., Mele, S., Urgesi, C., Gender differences in the neural underpinning of perceiving and appreciating the beauty of the body (2014) Behav. Brain Res., 264, pp. 188-196. , doi:10. 1016/j. bbr. 2014. 02. 001; Cowdrey, F.A., Filippini, N., Park, R.J., Smith, S.M., McCabe, C., Increased resting state functional connectivity in the default mode network in recovered anorexia nervosa (2014) Hum. Brain Mapp., 35, pp. 483-491. , doi:10. 1002/hbm. 22202; Cox, R.W., AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages (1996) Comput Biomed. Res., 29, pp. 162-173. , doi:10. 1006/cbmr. 1996. 0014; Curtis, C.E., D'Esposito, M., Persistent activity in the prefrontal cortex during working memory (2003) Trends Cogn. Sci., 7, pp. 415-423. , doi:10. 1016/S1364-6613(03)00197-9; Downing, P.E., Jiang, Y., Shuman, M., Kanwisher, N., A cortical area selective for visual processing of the human body (2001) Science, 293, pp. 2470-2473. , doi:10. 1126/science. 1063414; Eddy, K.T., Rauch, S.L., Neuroimaging in eating disorders: Coming of age (2011) Am. J. Psychiatry, 168, pp. 1139-1141. , doi:10. 1176/appi. ajp. 2011. 11071125; Eickhoff, S.B., Stephan, K.E., Mohlberg, H., Grefkes, C., Fink, G.R., Amunts, K., A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data (2005) Neuroimage, 25, pp. 1325-1335. , doi:10. 1016/j. neuroimage. 2004. 12. 034; Fairburn, C.G., Harrison, P.J., Eating disorders (2013) Lancet, 361, pp. 407-416. , doi:10. 1016/S0140-6736(03)12378-1; Fassino, S., Abbate-Daga, G., Resistance to treatment in eating disorders: A critical challenge (2013) BMC Psychiatry, 13, p. 282. , doi:10. 1186/1471-244X-13-282; Fassino, S., Pierò, A., Gramaglia, C., Abbate-Daga, G., Clinical, psychopathological and personality correlates of interoceptive awareness in anorexia nervosa, bulimia nervosa and obesity (2004) Psychopathology, 37, pp. 168-174. , doi:10. 1159/000079420; Favaro, A., Santonastaso, P., Manara, R., Bosello, R., Bommarito, G., Tenconi, E., Disruption of visuospatial and somatosensory functional connectivity in anorexia nervosa (2012) Biol. 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PY - 2014

Y1 - 2014

N2 - Background: Alterations in the resting-state functional connectivity (rs-FC) of several brain networks have been demonstrated in eating disorders. However, very few studies are currently available on brain network dysfunctions in bulimia nervosa (BN).The somatosensory network is central in processing body-related stimuli and it may be altered in BN. The present study therefore aimed to investigate rs-FC in the somatosensory network in bulimic women. Methods: Sixteen medication-free women with BN (age = 23 ± 5 years) and 18 matched controls (age = 23 ± 3 years) underwent a functional magnetic resonance resting-state scan and assessment of eating disorder symptoms. Within-network and seed-based functional connectivity analyses were conducted to assess rs-FC within the somatosensory network and to other areas of the brain. Results: Bulimia nervosa patients showed a decreased rs-FC both within the somatosensory network (t = 9.0, df = 1, P = 0.005) and with posterior cingulate cortex and two visual areas (the right middle occipital gyrus and the right cuneus) (P = 0.05 corrected for multiple comparison). The rs-FC of the left paracentral lobule with the right middle occipital gyrus correlated with psychopathology measures like bulimia (r = -0.4; P = 0.02) and interoceptive awareness (r = -0.4; P = 0.01). Analyses were conducted using age, BMI (body mass index), and depressive symptoms as covariates. Conclusion: Our findings show a specific alteration of the rs-FC of the somatosensory cortex in BN patients, which correlates with eating disorder symptoms. The region in the right middle occipital gyrus is implicated in body processing and is known as extrastriate body area (EBA). The connectivity between the somatosensory cortex and the EBA might be related to dysfunctions in body image processing. The results should be considered preliminary due to the small sample size. © 2014 Lavagnino, Amianto, D'Agata, Huang, Mortara, Abbate-Daga, Marzola, Spalatro, Fassino and Northoff.

AB - Background: Alterations in the resting-state functional connectivity (rs-FC) of several brain networks have been demonstrated in eating disorders. However, very few studies are currently available on brain network dysfunctions in bulimia nervosa (BN).The somatosensory network is central in processing body-related stimuli and it may be altered in BN. The present study therefore aimed to investigate rs-FC in the somatosensory network in bulimic women. Methods: Sixteen medication-free women with BN (age = 23 ± 5 years) and 18 matched controls (age = 23 ± 3 years) underwent a functional magnetic resonance resting-state scan and assessment of eating disorder symptoms. Within-network and seed-based functional connectivity analyses were conducted to assess rs-FC within the somatosensory network and to other areas of the brain. Results: Bulimia nervosa patients showed a decreased rs-FC both within the somatosensory network (t = 9.0, df = 1, P = 0.005) and with posterior cingulate cortex and two visual areas (the right middle occipital gyrus and the right cuneus) (P = 0.05 corrected for multiple comparison). The rs-FC of the left paracentral lobule with the right middle occipital gyrus correlated with psychopathology measures like bulimia (r = -0.4; P = 0.02) and interoceptive awareness (r = -0.4; P = 0.01). Analyses were conducted using age, BMI (body mass index), and depressive symptoms as covariates. Conclusion: Our findings show a specific alteration of the rs-FC of the somatosensory cortex in BN patients, which correlates with eating disorder symptoms. The region in the right middle occipital gyrus is implicated in body processing and is known as extrastriate body area (EBA). The connectivity between the somatosensory cortex and the EBA might be related to dysfunctions in body image processing. The results should be considered preliminary due to the small sample size. © 2014 Lavagnino, Amianto, D'Agata, Huang, Mortara, Abbate-Daga, Marzola, Spalatro, Fassino and Northoff.

KW - Bulimia

KW - Eating disorders

KW - fMRI

KW - Functional connectivity

KW - Resting state

KW - Somatosensory network

KW - adult

KW - age

KW - article

KW - awareness

KW - body mass

KW - bulimia

KW - clinical article

KW - controlled study

KW - cuneus

KW - depression

KW - female

KW - functional magnetic resonance imaging

KW - human

KW - mental disease

KW - occipital gyrus

KW - posterior cingulate

KW - prediction

KW - resting state functional connectivity

KW - resting state network

KW - somatosensory cortex

KW - symptomatology

KW - visual cortex

U2 - 10.3389/fnbeh.2014.00270

DO - 10.3389/fnbeh.2014.00270

M3 - Article

VL - 8

JO - Frontiers in Behavioral Neuroscience

JF - Frontiers in Behavioral Neuroscience

SN - 1662-5153

IS - AUG

ER -