Abstract

Background: Activation of inflammatory response system (IRS) is suggested by increased levels of plasma soluble interleukin-2 receptor (sIL-2R) in patients with bipolar mania. The reasons for changes in stimulated interferon-gamma (IFN-γ) and interleukin-10 (IL-10) production in bipolar mania along with subsequent remission remain unclear. Methods: We measured phytohemagglutinin (PHA)-stimulated IFN-γ and IL-10 production in 20 physically healthy inpatients aged between 18 and 45 years with bipolar mania (DSM-IV) using Young Mania Rating Scale (YMRS) scores ≥26 and in subsequent remission (YMRS≤12), as well as in 15 age- and sex-matched healthy normal controls. Results: The mean values of IFN-γ production in patients in acute mania and in subsequent remission were significantly lower than those of healthy controls (P=0.0004, P=0.0005, respectively). There was no significant difference in IL-10 production between bipolar patients in acute mania as well as in subsequent remission and healthy controls. In acute mania, the mean values of IFN-γ and IL-10 production in medicated patients (n=13) did not differ from those of drug-free patients (n=7). Other clinical variables had no effect on IFN-γ and IL-10 production. Limitation: The uncontrolled medication, small sample size of the bipolar individuals, and some immune re-measurements prior to full remission periods, limit generalization from the data in this study. Conclusion: Reduced production of IFN-γ without alternation of IL-10 in bipolar mania and subsequent remission suggest that the immune modulation may vary in patients with different major psychiatric disorders.

Original languageEnglish
Pages (from-to)205-209
Number of pages5
JournalJournal of Affective Disorders
Volume71
Issue number1-3
DOIs
Publication statusPublished - 2002

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Bipolar Disorder
Interleukin-10
Interferon-gamma
Interleukin-2 Receptors
Phytohemagglutinins
Diagnostic and Statistical Manual of Mental Disorders
Sample Size
Psychiatry
Inpatients
Pharmaceutical Preparations

Keywords

  • Bipolar disorder in Taiwan
  • Immune modulation
  • Interferon-γ
  • Interleukin-10
  • Mania

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

@article{7b9927d43a514322a807f519c7a10d80,
title = "Reduced production of interferon-gamma but not interleukin-10 in bipolar mania and subsequent remission",
abstract = "Background: Activation of inflammatory response system (IRS) is suggested by increased levels of plasma soluble interleukin-2 receptor (sIL-2R) in patients with bipolar mania. The reasons for changes in stimulated interferon-gamma (IFN-γ) and interleukin-10 (IL-10) production in bipolar mania along with subsequent remission remain unclear. Methods: We measured phytohemagglutinin (PHA)-stimulated IFN-γ and IL-10 production in 20 physically healthy inpatients aged between 18 and 45 years with bipolar mania (DSM-IV) using Young Mania Rating Scale (YMRS) scores ≥26 and in subsequent remission (YMRS≤12), as well as in 15 age- and sex-matched healthy normal controls. Results: The mean values of IFN-γ production in patients in acute mania and in subsequent remission were significantly lower than those of healthy controls (P=0.0004, P=0.0005, respectively). There was no significant difference in IL-10 production between bipolar patients in acute mania as well as in subsequent remission and healthy controls. In acute mania, the mean values of IFN-γ and IL-10 production in medicated patients (n=13) did not differ from those of drug-free patients (n=7). Other clinical variables had no effect on IFN-γ and IL-10 production. Limitation: The uncontrolled medication, small sample size of the bipolar individuals, and some immune re-measurements prior to full remission periods, limit generalization from the data in this study. Conclusion: Reduced production of IFN-γ without alternation of IL-10 in bipolar mania and subsequent remission suggest that the immune modulation may vary in patients with different major psychiatric disorders.",
keywords = "Bipolar disorder in Taiwan, Immune modulation, Interferon-γ, Interleukin-10, Mania",
author = "Su, {Kuan Pin} and Leu, {Sy Jye C} and Yang, {Yi Yuan} and Shen, {Winston W.} and Chou, {Yech Mei} and Tsai, {Shang Ying M}",
year = "2002",
doi = "10.1016/S0165-0327(01)00369-X",
language = "English",
volume = "71",
pages = "205--209",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",
number = "1-3",

}

TY - JOUR

T1 - Reduced production of interferon-gamma but not interleukin-10 in bipolar mania and subsequent remission

AU - Su, Kuan Pin

AU - Leu, Sy Jye C

AU - Yang, Yi Yuan

AU - Shen, Winston W.

AU - Chou, Yech Mei

AU - Tsai, Shang Ying M

PY - 2002

Y1 - 2002

N2 - Background: Activation of inflammatory response system (IRS) is suggested by increased levels of plasma soluble interleukin-2 receptor (sIL-2R) in patients with bipolar mania. The reasons for changes in stimulated interferon-gamma (IFN-γ) and interleukin-10 (IL-10) production in bipolar mania along with subsequent remission remain unclear. Methods: We measured phytohemagglutinin (PHA)-stimulated IFN-γ and IL-10 production in 20 physically healthy inpatients aged between 18 and 45 years with bipolar mania (DSM-IV) using Young Mania Rating Scale (YMRS) scores ≥26 and in subsequent remission (YMRS≤12), as well as in 15 age- and sex-matched healthy normal controls. Results: The mean values of IFN-γ production in patients in acute mania and in subsequent remission were significantly lower than those of healthy controls (P=0.0004, P=0.0005, respectively). There was no significant difference in IL-10 production between bipolar patients in acute mania as well as in subsequent remission and healthy controls. In acute mania, the mean values of IFN-γ and IL-10 production in medicated patients (n=13) did not differ from those of drug-free patients (n=7). Other clinical variables had no effect on IFN-γ and IL-10 production. Limitation: The uncontrolled medication, small sample size of the bipolar individuals, and some immune re-measurements prior to full remission periods, limit generalization from the data in this study. Conclusion: Reduced production of IFN-γ without alternation of IL-10 in bipolar mania and subsequent remission suggest that the immune modulation may vary in patients with different major psychiatric disorders.

AB - Background: Activation of inflammatory response system (IRS) is suggested by increased levels of plasma soluble interleukin-2 receptor (sIL-2R) in patients with bipolar mania. The reasons for changes in stimulated interferon-gamma (IFN-γ) and interleukin-10 (IL-10) production in bipolar mania along with subsequent remission remain unclear. Methods: We measured phytohemagglutinin (PHA)-stimulated IFN-γ and IL-10 production in 20 physically healthy inpatients aged between 18 and 45 years with bipolar mania (DSM-IV) using Young Mania Rating Scale (YMRS) scores ≥26 and in subsequent remission (YMRS≤12), as well as in 15 age- and sex-matched healthy normal controls. Results: The mean values of IFN-γ production in patients in acute mania and in subsequent remission were significantly lower than those of healthy controls (P=0.0004, P=0.0005, respectively). There was no significant difference in IL-10 production between bipolar patients in acute mania as well as in subsequent remission and healthy controls. In acute mania, the mean values of IFN-γ and IL-10 production in medicated patients (n=13) did not differ from those of drug-free patients (n=7). Other clinical variables had no effect on IFN-γ and IL-10 production. Limitation: The uncontrolled medication, small sample size of the bipolar individuals, and some immune re-measurements prior to full remission periods, limit generalization from the data in this study. Conclusion: Reduced production of IFN-γ without alternation of IL-10 in bipolar mania and subsequent remission suggest that the immune modulation may vary in patients with different major psychiatric disorders.

KW - Bipolar disorder in Taiwan

KW - Immune modulation

KW - Interferon-γ

KW - Interleukin-10

KW - Mania

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U2 - 10.1016/S0165-0327(01)00369-X

DO - 10.1016/S0165-0327(01)00369-X

M3 - Article

C2 - 12167518

AN - SCOPUS:0036348813

VL - 71

SP - 205

EP - 209

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

IS - 1-3

ER -