Reduced medication use and improved pulmonary function with supplements containing vegetable and fruit concentrate, fish oil and probiotics in asthmatic school children

A randomised controlled trial

Shu Chen Lee, Yao Hsu Yang, Shao Yuan Chuang, Shih Yi Huang, Wen Harn Pan

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Dietary pattern changes may be one of the key factors associated with increasing asthma prevalence. Observational studies have found negative associations between fruit, vegetable and fish consumption and risk of asthma. Experimental studies have also shown that probiotics can modulate the immune system. However, each dietary component exhibits a modest effect. The objective of the present study was to investigate the joint effect of multiple beneficial dietary components on asthma. We designed a 16-week school-based double-blind placebo-controlled randomised trial. The supplement group received fruit plus vegetable concentrate, fish oil and probiotics (FVFP supplement), while the control group received placebos. A total of 192 asthmatic children aged 10-12 years were recruited from elementary schools in metropolitan Taipei. Pulmonary function, medication usage, Paediatric Asthma Quality of Life Questionnaire (PAQLQ) score and the Childhood Asthma Control Test score were evaluated at baseline, and at weeks 8 and 16. Compared with the placebo group, the supplement group showed significant improvement in pulmonary function parameters (91 v. 178 ml for forced vital capacity (FVC), 40 v. 107 ml for forced expiratory volume in 1 s (FEV1) and 1·6 v. 4·8 % for FEV1:FVC ratio; all P values <0·01) and had a significantly reduced proportion of those using short-acting inhaled bronchodilators and inhaled corticosteroids. However, the PAQLQ score and the Childhood Asthma Control Test score were not significantly different between the two groups, possibly because the majority of the children were treated routinely. FVFP supplements reduced medication use and improved pulmonary function in asthmatic children. The present study supports an adjuvant intervention with a combination of fruit, vegetable, fish and probiotic foods.

Original languageEnglish
Pages (from-to)145-155
Number of pages11
JournalBritish Journal of Nutrition
Volume110
Issue number1
DOIs
Publication statusPublished - Jul 14 2013

Fingerprint

Fish Oils
Probiotics
Vegetables
Fruit
Asthma
Randomized Controlled Trials
Lung
Vital Capacity
Placebos
Forced Expiratory Volume
Fishes
Quality of Life
Pediatrics
Bronchodilator Agents
Observational Studies
Immune System
Adrenal Cortex Hormones
Food
Control Groups

Keywords

  • Asthma
  • Children
  • Fish oil
  • Fruits and vegetables
  • Probiotics

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Reduced medication use and improved pulmonary function with supplements containing vegetable and fruit concentrate, fish oil and probiotics in asthmatic school children : A randomised controlled trial. / Lee, Shu Chen; Yang, Yao Hsu; Chuang, Shao Yuan; Huang, Shih Yi; Pan, Wen Harn.

In: British Journal of Nutrition, Vol. 110, No. 1, 14.07.2013, p. 145-155.

Research output: Contribution to journalArticle

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