Reduced expression of tocopherol-associated protein (TAP/Sec14L2) in human breast cancer.

X. Wang, Jing Ni, Chen Long Hsu, Sharlin Johnykutty, Ping Tang, Yuan Soon Ho, Chia Hwa Lee, Shuyuang Yeh

Research output: Contribution to journalArticle

Abstract

We show that TAP/Sec14L2 had a high expression in normal/benign breast, prostate, and liver tissues as compared to lung, colon, and kidney. Its expression was downregulated in breast cancer cell lines shown by quantitative-PCR. Further, 57% of 141 human invasive breast carcinomas had no or markedly reduced TAP/Sec14L2 expression by immunohistochemical staining, and the rate increased to 80% in high grade invasive carcinomas (p <.01). This downregulation of TAP/Sec14L2 was also present in ductal carcinoma in situ (DCIS) associated with invasive carcinomas. These findings raise the possibility that TAP/Sec14L2 may serve as a tumor suppressor in breast carcinogenesis.

Original languageEnglish
Pages (from-to)971-977
Number of pages7
JournalCancer Investigation
Volume27
Issue number10
Publication statusPublished - Dec 2009
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Wang, X., Ni, J., Hsu, C. L., Johnykutty, S., Tang, P., Ho, Y. S., Lee, C. H., & Yeh, S. (2009). Reduced expression of tocopherol-associated protein (TAP/Sec14L2) in human breast cancer. Cancer Investigation, 27(10), 971-977.