Reduced activation and altered laterality in two neuroleptic-naive catatonic patients during a motor task in functional MRI

G. Northoff, D. F. Braus, A. Sartorius, D. Khoram-Sefat, M. Russ, J. Eckert, M. Herrig, A. Leschinger, B. Bogerts, F. A. Henn

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Background. Catatonia, a symptom complex with motor, affective and cognitive symptoms seen in a variety of psychotic conditions and with organic disease, was examined using a motor task using functional magnetic resonance imaging (fMRI). Methods. Two acute catatonic patients and two age- and sex-matched healthy controls performed sequential finger opposition (SFO) after being medicated with 2 mg of lorazepam (i.v.). Functional magnetic resonance images were collected using a gradient echo pulse sequence (EPI). Results. Patients with catatonia showed reduced motor activation of the contralateral motor cortex during SFO of the right hand, ipsilateral activation was similar for patients and controls. There were no differences in the activation of the SMA. During left hand activation the right-handed catatonic patients showed more activation in the ipsilateral cortex, a reversal from the normal pattern of activation in which the contralateral side shows four to five times more activation than the ipsilateral side. Conclusions. In catatonic patients there is a decreased activation in motor cortex during a motor task compared to matched medicated healthy controls. In addition activation of the non-dominant side, left-handed activity in right-handed patients, results in a total reversal of the normal pattern of lateral activation suggesting a disturbance in hemispheric localization of activity during a catatonic state.

Original languageEnglish
Pages (from-to)997-1002
Number of pages6
JournalPsychological Medicine
Volume29
Issue number4
DOIs
Publication statusPublished - 1999

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Antipsychotic Agents
Magnetic Resonance Imaging
Catatonia
Motor Cortex
Fingers
Hand
Lorazepam
Neurobehavioral Manifestations
Affective Symptoms
Patient Rights
Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)
  • Clinical Psychology

Cite this

Reduced activation and altered laterality in two neuroleptic-naive catatonic patients during a motor task in functional MRI. / Northoff, G.; Braus, D. F.; Sartorius, A.; Khoram-Sefat, D.; Russ, M.; Eckert, J.; Herrig, M.; Leschinger, A.; Bogerts, B.; Henn, F. A.

In: Psychological Medicine, Vol. 29, No. 4, 1999, p. 997-1002.

Research output: Contribution to journalArticle

Northoff, G, Braus, DF, Sartorius, A, Khoram-Sefat, D, Russ, M, Eckert, J, Herrig, M, Leschinger, A, Bogerts, B & Henn, FA 1999, 'Reduced activation and altered laterality in two neuroleptic-naive catatonic patients during a motor task in functional MRI', Psychological Medicine, vol. 29, no. 4, pp. 997-1002. https://doi.org/10.1017/S0033291798007739
Northoff, G. ; Braus, D. F. ; Sartorius, A. ; Khoram-Sefat, D. ; Russ, M. ; Eckert, J. ; Herrig, M. ; Leschinger, A. ; Bogerts, B. ; Henn, F. A. / Reduced activation and altered laterality in two neuroleptic-naive catatonic patients during a motor task in functional MRI. In: Psychological Medicine. 1999 ; Vol. 29, No. 4. pp. 997-1002.
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AU - Northoff, G.

AU - Braus, D. F.

AU - Sartorius, A.

AU - Khoram-Sefat, D.

AU - Russ, M.

AU - Eckert, J.

AU - Herrig, M.

AU - Leschinger, A.

AU - Bogerts, B.

AU - Henn, F. A.

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N2 - Background. Catatonia, a symptom complex with motor, affective and cognitive symptoms seen in a variety of psychotic conditions and with organic disease, was examined using a motor task using functional magnetic resonance imaging (fMRI). Methods. Two acute catatonic patients and two age- and sex-matched healthy controls performed sequential finger opposition (SFO) after being medicated with 2 mg of lorazepam (i.v.). Functional magnetic resonance images were collected using a gradient echo pulse sequence (EPI). Results. Patients with catatonia showed reduced motor activation of the contralateral motor cortex during SFO of the right hand, ipsilateral activation was similar for patients and controls. There were no differences in the activation of the SMA. During left hand activation the right-handed catatonic patients showed more activation in the ipsilateral cortex, a reversal from the normal pattern of activation in which the contralateral side shows four to five times more activation than the ipsilateral side. Conclusions. In catatonic patients there is a decreased activation in motor cortex during a motor task compared to matched medicated healthy controls. In addition activation of the non-dominant side, left-handed activity in right-handed patients, results in a total reversal of the normal pattern of lateral activation suggesting a disturbance in hemispheric localization of activity during a catatonic state.

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