Recurrent minimal change disease post-allograft renal transplant

C. I. Jan, A. Chen, G. H. Sun, D. S. Yu, C. Y. Yen, J. S. Chen, Y. F. Lin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A young adult was diagnosed with steroid-resistant minimal change disease (MCD) without evidence of focal segmental glomerulosclerosis (FSGS) despite serial and detailed sectioning and screening of the renal biopsy. He received initial treatment with steroids and then cyclosporine plus low-dose steroids for 2 years. Renal function progressively deteriorated due to resistance to steroid and cyclosporine. Two months after initiation of hemodialysis, the patient received a living-related allogenic kidney transplant. However, recurrent nephrotic syndrome and renal insufficiency occurred after transplantation. In spite of aggressive treatment, renal function showed no significant improvement. The kidney graft was removed 2 weeks after transplantation. Serial sectioning and thorough sampling and screening revealed no evidence of FSGS, but light microscopy and electron microscopy showed the typical morphologic pattern of MCD, corresponding to the pretransplant diagnosis. We believe that this is the first reported case of recurrent MCD after renal transplant.

Original languageEnglish
Pages (from-to)2888-2890
Number of pages3
JournalTransplantation Proceedings
Volume35
Issue number8
DOIs
Publication statusPublished - Dec 2003
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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