Reciprocal relationship of Tn/NF-κB and sTn as an indicator of the prognosis of oral squamous cell carcinoma

Chi Yu Lin, Jar Yi Ho, Meng Ti Hsieh, H. L. Chiang, Jei Min Chuang, Jacqueline Whang-Peng, Yun Ching Chang, Yi Han Tseng, Su Feng Chen, Shin Nieh, Jau-Lang Hwang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Aims: In order to determine whether the expression of tumour-associated carbohydrate antigens (Tn/sTn) and a representative inflammation marker, nuclear factor-κB (NF-κB), is associated with the invasiveness of oral squamous cell carcinoma (OSCC), this study has attempted to investigate the correlation of the aforementioned markers with the well-established invasive pattern grading score (IPGS) and clinicopathological parameters. Methods and results: Specimens from 143 OSCC patients with classified clinicopathological parameters and IPGS were stained immunohistochemically using anti-Tn, sTn and NF-κB antibodies. Our results showed that the expression of both Tn and NF-κB was correlated positively with staging (P = 0.036; P = 0.015), recurrence (P <0.001; P <0.001) and distant metastasis (P = 0.005; P = 0.009), as well as with IPGS, while the expression of sTn was correlated inversely. In addition, poor survival was associated with overexpression of Tn and NF-κB but not with expression of sTn. Conclusions: Our results indicate that a reciprocal relationship between Tn and sTn expression may serve as a reliable indicator for OSCC prognostic evaluation. In addition, expression of Tn rather than sTn may play an important role in deeply invasive OSCC via regulation of NF-κB signalling.

Original languageEnglish
Pages (from-to)713-721
Number of pages9
JournalHistopathology
Volume64
Issue number5
DOIs
Publication statusPublished - 2014

Keywords

  • Invasive pattern grading score
  • Nuclear factor-κB
  • Oral squamous cell carcinoma
  • Tumour-associated carbohydrate antigen

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine
  • Medicine(all)

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  • Cite this

    Lin, C. Y., Ho, J. Y., Hsieh, M. T., Chiang, H. L., Chuang, J. M., Whang-Peng, J., Chang, Y. C., Tseng, Y. H., Chen, S. F., Nieh, S., & Hwang, J-L. (2014). Reciprocal relationship of Tn/NF-κB and sTn as an indicator of the prognosis of oral squamous cell carcinoma. Histopathology, 64(5), 713-721. https://doi.org/10.1111/his.12309