Reciprocal relationship of Tn/NF-κB and sTn as an indicator of the prognosis of oral squamous cell carcinoma

Chi Yu Lin, Jar Yi Ho, Meng Ti Hsieh, H. L. Chiang, Jei Min Chuang, Jacqueline Whang-Peng, Yun Ching Chang, Yi Han Tseng, Su Feng Chen, Shin Nieh, Jau-Lang Hwang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Aims: In order to determine whether the expression of tumour-associated carbohydrate antigens (Tn/sTn) and a representative inflammation marker, nuclear factor-κB (NF-κB), is associated with the invasiveness of oral squamous cell carcinoma (OSCC), this study has attempted to investigate the correlation of the aforementioned markers with the well-established invasive pattern grading score (IPGS) and clinicopathological parameters. Methods and results: Specimens from 143 OSCC patients with classified clinicopathological parameters and IPGS were stained immunohistochemically using anti-Tn, sTn and NF-κB antibodies. Our results showed that the expression of both Tn and NF-κB was correlated positively with staging (P = 0.036; P = 0.015), recurrence (P <0.001; P <0.001) and distant metastasis (P = 0.005; P = 0.009), as well as with IPGS, while the expression of sTn was correlated inversely. In addition, poor survival was associated with overexpression of Tn and NF-κB but not with expression of sTn. Conclusions: Our results indicate that a reciprocal relationship between Tn and sTn expression may serve as a reliable indicator for OSCC prognostic evaluation. In addition, expression of Tn rather than sTn may play an important role in deeply invasive OSCC via regulation of NF-κB signalling.

Original languageEnglish
Pages (from-to)713-721
Number of pages9
JournalHistopathology
Volume64
Issue number5
DOIs
Publication statusPublished - 2014

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Squamous Cell Carcinoma
Tumor-Associated Carbohydrate Antigens
Neoplasm Metastasis
Inflammation
Recurrence
Survival
Antibodies

Keywords

  • Invasive pattern grading score
  • Nuclear factor-κB
  • Oral squamous cell carcinoma
  • Tumour-associated carbohydrate antigen

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine
  • Medicine(all)

Cite this

Reciprocal relationship of Tn/NF-κB and sTn as an indicator of the prognosis of oral squamous cell carcinoma. / Lin, Chi Yu; Ho, Jar Yi; Hsieh, Meng Ti; Chiang, H. L.; Chuang, Jei Min; Whang-Peng, Jacqueline; Chang, Yun Ching; Tseng, Yi Han; Chen, Su Feng; Nieh, Shin; Hwang, Jau-Lang.

In: Histopathology, Vol. 64, No. 5, 2014, p. 713-721.

Research output: Contribution to journalArticle

Lin, CY, Ho, JY, Hsieh, MT, Chiang, HL, Chuang, JM, Whang-Peng, J, Chang, YC, Tseng, YH, Chen, SF, Nieh, S & Hwang, J-L 2014, 'Reciprocal relationship of Tn/NF-κB and sTn as an indicator of the prognosis of oral squamous cell carcinoma', Histopathology, vol. 64, no. 5, pp. 713-721. https://doi.org/10.1111/his.12309
Lin, Chi Yu ; Ho, Jar Yi ; Hsieh, Meng Ti ; Chiang, H. L. ; Chuang, Jei Min ; Whang-Peng, Jacqueline ; Chang, Yun Ching ; Tseng, Yi Han ; Chen, Su Feng ; Nieh, Shin ; Hwang, Jau-Lang. / Reciprocal relationship of Tn/NF-κB and sTn as an indicator of the prognosis of oral squamous cell carcinoma. In: Histopathology. 2014 ; Vol. 64, No. 5. pp. 713-721.
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AU - Lin, Chi Yu

AU - Ho, Jar Yi

AU - Hsieh, Meng Ti

AU - Chiang, H. L.

AU - Chuang, Jei Min

AU - Whang-Peng, Jacqueline

AU - Chang, Yun Ching

AU - Tseng, Yi Han

AU - Chen, Su Feng

AU - Nieh, Shin

AU - Hwang, Jau-Lang

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AB - Aims: In order to determine whether the expression of tumour-associated carbohydrate antigens (Tn/sTn) and a representative inflammation marker, nuclear factor-κB (NF-κB), is associated with the invasiveness of oral squamous cell carcinoma (OSCC), this study has attempted to investigate the correlation of the aforementioned markers with the well-established invasive pattern grading score (IPGS) and clinicopathological parameters. Methods and results: Specimens from 143 OSCC patients with classified clinicopathological parameters and IPGS were stained immunohistochemically using anti-Tn, sTn and NF-κB antibodies. Our results showed that the expression of both Tn and NF-κB was correlated positively with staging (P = 0.036; P = 0.015), recurrence (P <0.001; P <0.001) and distant metastasis (P = 0.005; P = 0.009), as well as with IPGS, while the expression of sTn was correlated inversely. In addition, poor survival was associated with overexpression of Tn and NF-κB but not with expression of sTn. Conclusions: Our results indicate that a reciprocal relationship between Tn and sTn expression may serve as a reliable indicator for OSCC prognostic evaluation. In addition, expression of Tn rather than sTn may play an important role in deeply invasive OSCC via regulation of NF-κB signalling.

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