Receptor proteins for nongenomic actions of thyroid hormone

Paul J. Davis, Jack L. Leonard, Hung Yun Lin, Sandra Incerpi, Mary K. Luidens, Heng Yuan Tang, Shaker A. Mousa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Genomic actions of thyroid hormone require the intranuclear binding by nuclear thyroid hormone receptors (TRs) of 3,5,3’-triiodo-L-thyronine (T3). Nongenomic actions of the hormone have been described that are initiated at the plasma membrane, in cytoplasm or in the mitochondrion. These are complex processes associated with maintenance of the cytoskeleton, control of cell respiration, cell proliferation—including tumor cell proliferation and angiogenesis—and nervous system function. We briefly review here the nature of the proteins which are now appreciated to initiate nongenomic actions of the hormone when they bind T3 or L-thyroxine (T4). These receptor proteins for nongenomic effects include truncated isoforms of TRα, cytoplasmic intact TRβ, certain cytoplasmic enzymes and a structural protein of the plasma membrane, integrin αvβ3.

Original languageEnglish
Pages (from-to)94-97
Number of pages4
JournalImmunology, Endocrine and Metabolic Agents in Medicinal Chemistry
Volume15
Issue number1
Publication statusPublished - Jul 1 2015

Fingerprint

Thyroid Hormone Receptors
Thyroid Hormones
Cell Membrane
Thyronines
Hormones
Cell Respiration
Proteins
Cytoplasmic and Nuclear Receptors
Cytoskeleton
Thyroxine
Integrins
Nervous System
Mitochondria
Protein Isoforms
Cytoplasm
Maintenance
Cell Proliferation
Enzymes
Neoplasms

Keywords

  • Integrin αvβ3
  • p28 TRα1
  • p43 TRα1
  • Pyruvate kinase M1
  • TRα1
  • TRβ
  • TRΔα1
  • μ-Crystallin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Pharmacology

Cite this

Davis, P. J., Leonard, J. L., Lin, H. Y., Incerpi, S., Luidens, M. K., Tang, H. Y., & Mousa, S. A. (2015). Receptor proteins for nongenomic actions of thyroid hormone. Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, 15(1), 94-97.

Receptor proteins for nongenomic actions of thyroid hormone. / Davis, Paul J.; Leonard, Jack L.; Lin, Hung Yun; Incerpi, Sandra; Luidens, Mary K.; Tang, Heng Yuan; Mousa, Shaker A.

In: Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, Vol. 15, No. 1, 01.07.2015, p. 94-97.

Research output: Contribution to journalArticle

Davis, PJ, Leonard, JL, Lin, HY, Incerpi, S, Luidens, MK, Tang, HY & Mousa, SA 2015, 'Receptor proteins for nongenomic actions of thyroid hormone', Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, vol. 15, no. 1, pp. 94-97.
Davis, Paul J. ; Leonard, Jack L. ; Lin, Hung Yun ; Incerpi, Sandra ; Luidens, Mary K. ; Tang, Heng Yuan ; Mousa, Shaker A. / Receptor proteins for nongenomic actions of thyroid hormone. In: Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. 2015 ; Vol. 15, No. 1. pp. 94-97.
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