Recent Advances in Understanding of Alternative Splicing in Neuronal Pathogenesis

Hung Hsi Chen, Jung-Chun Lin, Woan Yuh Tarn

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The nervous system is an intricate and highly specialized network of neurons. Neuronal differentiation involves complex reprogramming of gene expression. Alternative splicing of precursor mRNAs increases the complexity of transcriptomes and diversifies protein functions at the post-transcriptional level. Indeed, alternative splicing plays an important role in neuronal differentiation, axon guidance, synaptogenesis, synaptic transmission, and plasticity. Because the delicate structure and function of neurons make them particularly susceptible to dysregulation of splicing, aberrant expression or function of splicing factors may cause neuronal disorders. Therefore, it is important to improve our understanding of the mechanisms and physiological functions of alternative splicing regulation in neurons. Regulation of alternative splicing primarily involves the binding of regulatory factors to specific cis-elements of precursor mRNAs, and interplay between splicing factors may lead to fine tuning of splicing regulation, thereby diversifying the cadre of mature products. In addition, transcription rate and the availability of the basal splicing machinery may also influence alternative splicing. Recently, our understanding of the mechanisms underlying alternative splicing have been advanced from studies of several neuronal splicing factors; these studies have utilized genetic knockout or disease models as well as genome-wide analysis of mRNA isoforms. In this chapter, we review current understanding of alternative splicing in neurons.
Original languageEnglish
Title of host publicationRNA Processing
PublisherINTECH Open Access Publisher
Pages207-228
Number of pages22
ISBN (Print)9533075570
Publication statusPublished - 2011

Fingerprint

Alternative Splicing
Neurons
RNA Precursors
RNA Isoforms
Neuronal Plasticity
Transcriptome
Synaptic Transmission
Nervous System
Genome
Gene Expression
RNA Splicing Factors
Proteins

Cite this

Chen, H. H., Lin, J-C., & Tarn, W. Y. (2011). Recent Advances in Understanding of Alternative Splicing in Neuronal Pathogenesis. In RNA Processing (pp. 207-228). INTECH Open Access Publisher.

Recent Advances in Understanding of Alternative Splicing in Neuronal Pathogenesis. / Chen, Hung Hsi; Lin, Jung-Chun; Tarn, Woan Yuh.

RNA Processing. INTECH Open Access Publisher, 2011. p. 207-228.

Research output: Chapter in Book/Report/Conference proceedingChapter

Chen, HH, Lin, J-C & Tarn, WY 2011, Recent Advances in Understanding of Alternative Splicing in Neuronal Pathogenesis. in RNA Processing. INTECH Open Access Publisher, pp. 207-228.
Chen HH, Lin J-C, Tarn WY. Recent Advances in Understanding of Alternative Splicing in Neuronal Pathogenesis. In RNA Processing. INTECH Open Access Publisher. 2011. p. 207-228
Chen, Hung Hsi ; Lin, Jung-Chun ; Tarn, Woan Yuh. / Recent Advances in Understanding of Alternative Splicing in Neuronal Pathogenesis. RNA Processing. INTECH Open Access Publisher, 2011. pp. 207-228
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