Recent advances in nanoparticle-based förster resonance energy transfer for biosensing, molecular imaging and drug release profiling

Nai Tzu Chen, Shih Hsun Cheng, Ching Ping Liu, Jeffrey S. Souris, Chen Tu Chen, Chung Yuan Mou, Leu Wei Lo

Research output: Contribution to journalReview articlepeer-review

103 Citations (Scopus)

Abstract

Förster resonance energy transfer (FRET) may be regarded as a 'smart' technology in the design of fluorescence probes for biological sensing and imaging. Recently, a variety of nanoparticles that include quantum dots, gold nanoparticles, polymer, mesoporous silica nanoparticles and upconversion nanoparticles have been employed to modulate FRET. Researchers have developed a number of 'visible' and 'activatable' FRET probes sensitive to specific changes in the biological environment that are especially attractive from the biomedical point of view. This article reviews recent progress in bringing these nanoparticle-modulated energy transfer schemes to fruition for applications in biosensing, molecular imaging and drug delivery.

Original languageEnglish
Pages (from-to)16598-16623
Number of pages26
JournalInternational journal of molecular sciences
Volume13
Issue number12
DOIs
Publication statusPublished - Dec 2012
Externally publishedYes

Keywords

  • Biosensing
  • Drug controlled release
  • Förster resonance energy transfer
  • FRET
  • Gold nanoparticles
  • Mesoporous silica nanoparticles
  • Molecular imaging
  • Nanoparticle
  • Quantum dots
  • Upconversion nanoparticle

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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