Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules

Mei Chin Chen, Fwu Long Mi, Zi Xian Liao, Chun Wen Hsiao, Kiran Sonaje, Min Fan Chung, Li Wen Hsu, Hsing Wen Sung

Research output: Contribution to journalArticle

208 Citations (Scopus)

Abstract

Chitosan (CS), a cationic polysaccharide, is widely regarded as a safe and efficient intestinal absorption enhancer of therapeutic macromolecules, owing to its inherent mucoadhesive feature and ability to modulate the integrity of epithelial tight junctions reversibly. By using CS-based nanoparticles, many studies have attempted to protect the loaded macromolecules against acidic denaturation and enzymatic degradation, prolong their intestinal residence time, and increase their absorption by the intestinal epithelium. Derivatives of CS such as quaternized CS, thiolated CS and carboxylated CS have also been examined to further enhance its effectiveness in oral absorption of macromolecular drugs. This review article describes the synthesis of these CS derivatives and their characteristics, as well as their potential transport mechanisms of macromolecular therapeutics across the intestinal biological membrane. Recent advances in using CS and its derivatives as carriers for oral delivery of hydrophilic macromolecules and their effects on drug transport are also reviewed.

Original languageEnglish
Pages (from-to)865-879
Number of pages15
JournalAdvanced Drug Delivery Reviews
Volume65
Issue number6
DOIs
Publication statusPublished - Jun 15 2013

Fingerprint

Chitosan
Nanoparticles
Tight Junctions
Intestinal Absorption
Intestinal Mucosa
Pharmaceutical Preparations
Polysaccharides
Membranes
Therapeutics

Keywords

  • Bioavailability
  • Mucoadhesion
  • Oral drug delivery
  • Paracellular pathway
  • Tight junction
  • Transcellular pathway

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules. / Chen, Mei Chin; Mi, Fwu Long; Liao, Zi Xian; Hsiao, Chun Wen; Sonaje, Kiran; Chung, Min Fan; Hsu, Li Wen; Sung, Hsing Wen.

In: Advanced Drug Delivery Reviews, Vol. 65, No. 6, 15.06.2013, p. 865-879.

Research output: Contribution to journalArticle

Chen, MC, Mi, FL, Liao, ZX, Hsiao, CW, Sonaje, K, Chung, MF, Hsu, LW & Sung, HW 2013, 'Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules', Advanced Drug Delivery Reviews, vol. 65, no. 6, pp. 865-879. https://doi.org/10.1016/j.addr.2012.10.010
Chen, Mei Chin ; Mi, Fwu Long ; Liao, Zi Xian ; Hsiao, Chun Wen ; Sonaje, Kiran ; Chung, Min Fan ; Hsu, Li Wen ; Sung, Hsing Wen. / Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules. In: Advanced Drug Delivery Reviews. 2013 ; Vol. 65, No. 6. pp. 865-879.
@article{335ba0b42c0148f18967611a2cb02387,
title = "Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules",
abstract = "Chitosan (CS), a cationic polysaccharide, is widely regarded as a safe and efficient intestinal absorption enhancer of therapeutic macromolecules, owing to its inherent mucoadhesive feature and ability to modulate the integrity of epithelial tight junctions reversibly. By using CS-based nanoparticles, many studies have attempted to protect the loaded macromolecules against acidic denaturation and enzymatic degradation, prolong their intestinal residence time, and increase their absorption by the intestinal epithelium. Derivatives of CS such as quaternized CS, thiolated CS and carboxylated CS have also been examined to further enhance its effectiveness in oral absorption of macromolecular drugs. This review article describes the synthesis of these CS derivatives and their characteristics, as well as their potential transport mechanisms of macromolecular therapeutics across the intestinal biological membrane. Recent advances in using CS and its derivatives as carriers for oral delivery of hydrophilic macromolecules and their effects on drug transport are also reviewed.",
keywords = "Bioavailability, Mucoadhesion, Oral drug delivery, Paracellular pathway, Tight junction, Transcellular pathway",
author = "Chen, {Mei Chin} and Mi, {Fwu Long} and Liao, {Zi Xian} and Hsiao, {Chun Wen} and Kiran Sonaje and Chung, {Min Fan} and Hsu, {Li Wen} and Sung, {Hsing Wen}",
year = "2013",
month = "6",
day = "15",
doi = "10.1016/j.addr.2012.10.010",
language = "English",
volume = "65",
pages = "865--879",
journal = "Advanced Drug Delivery Reviews",
issn = "0169-409X",
publisher = "Elsevier",
number = "6",

}

TY - JOUR

T1 - Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules

AU - Chen, Mei Chin

AU - Mi, Fwu Long

AU - Liao, Zi Xian

AU - Hsiao, Chun Wen

AU - Sonaje, Kiran

AU - Chung, Min Fan

AU - Hsu, Li Wen

AU - Sung, Hsing Wen

PY - 2013/6/15

Y1 - 2013/6/15

N2 - Chitosan (CS), a cationic polysaccharide, is widely regarded as a safe and efficient intestinal absorption enhancer of therapeutic macromolecules, owing to its inherent mucoadhesive feature and ability to modulate the integrity of epithelial tight junctions reversibly. By using CS-based nanoparticles, many studies have attempted to protect the loaded macromolecules against acidic denaturation and enzymatic degradation, prolong their intestinal residence time, and increase their absorption by the intestinal epithelium. Derivatives of CS such as quaternized CS, thiolated CS and carboxylated CS have also been examined to further enhance its effectiveness in oral absorption of macromolecular drugs. This review article describes the synthesis of these CS derivatives and their characteristics, as well as their potential transport mechanisms of macromolecular therapeutics across the intestinal biological membrane. Recent advances in using CS and its derivatives as carriers for oral delivery of hydrophilic macromolecules and their effects on drug transport are also reviewed.

AB - Chitosan (CS), a cationic polysaccharide, is widely regarded as a safe and efficient intestinal absorption enhancer of therapeutic macromolecules, owing to its inherent mucoadhesive feature and ability to modulate the integrity of epithelial tight junctions reversibly. By using CS-based nanoparticles, many studies have attempted to protect the loaded macromolecules against acidic denaturation and enzymatic degradation, prolong their intestinal residence time, and increase their absorption by the intestinal epithelium. Derivatives of CS such as quaternized CS, thiolated CS and carboxylated CS have also been examined to further enhance its effectiveness in oral absorption of macromolecular drugs. This review article describes the synthesis of these CS derivatives and their characteristics, as well as their potential transport mechanisms of macromolecular therapeutics across the intestinal biological membrane. Recent advances in using CS and its derivatives as carriers for oral delivery of hydrophilic macromolecules and their effects on drug transport are also reviewed.

KW - Bioavailability

KW - Mucoadhesion

KW - Oral drug delivery

KW - Paracellular pathway

KW - Tight junction

KW - Transcellular pathway

UR - http://www.scopus.com/inward/record.url?scp=84878862620&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878862620&partnerID=8YFLogxK

U2 - 10.1016/j.addr.2012.10.010

DO - 10.1016/j.addr.2012.10.010

M3 - Article

VL - 65

SP - 865

EP - 879

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

SN - 0169-409X

IS - 6

ER -