Abstract
Devices based on semiconducting nanowires (NWs) are functioning as highly sensitive and selective sensors for the label-free detection of biological and chemical species. This paper demonstrates a novel back-gated silicon NW field effect transistor (NWFET) for gene detection. The fabricated NWFET was employed as the biomolecule sensor for the early, real-time, and label-free screening of hepatitis B virus (HBV) X gene. The DNA fragment in HBV demonstrates the linearity from 10 fM to 1 pM, of which the detection limit is estimated to be about 3.2 fM. The obtained results also show that the NW-based sensor can distinguish the difference between the complementary and 1-base mismatch DNA. The back-gated NW FET exhibits a label-free, highly sensitive, and selective biosensor for gene detection, which also provides a possibility of multiple chemical and biological species detection with sensor array in an integrated chip.
Original language | English |
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Pages (from-to) | 273-277 |
Number of pages | 5 |
Journal | Journal of Polymer Engineering |
Volume | 34 |
Issue number | 3 |
DOIs | |
Publication status | Published - May 1 2014 |
Keywords
- field-effect transistor
- hepatitis B virus
- label-free
- nanowire
- X gene
ASJC Scopus subject areas
- Materials Chemistry
- Polymers and Plastics
- Chemical Engineering(all)