Reactive oxygen species are the cause of the enhanced cardiorespiratory response induced by intermittent hypoxia in conscious rats

Terry B J Kuo, Zung Fan Yuan, You Shuei Lin, Yi Ning Lin, Weng Shan Li, Cheryl C H Yang, Ching Jung Lai

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11 Citations (Scopus)


This study was carried out to investigate the role of reactive oxygen species (ROS) in the elevation of cardiorespiratory responses during the development of intermittent hypoxia (IH)-induced hypertension. Rats were exposed to either 30 days of IH [(30s N2)+(45s room air (RA)] or RA for 6h/day. After 5 days of exposure, stable mean arterial pressure, normalized low-frequency power of pulses interval spectrogram (a marker of cardiac sympathetic outflow), and minute ventilation (an index for arterial chemoreflex activation) were significantly increased throughout the observation period in IH-exposed rats, but not in RA-exposed rats. FosB expression in rostral ventrolateral medulla was elevated after IH exposure for 5 days. Intraperitoneal injection of MnTMPyP (a superoxide scavenger) or N-acetylcysteine (an antioxidant) prevented IH-induced elevation of the cardiorespiratory responses and lipid peroxidation of lung tissues. These results suggest that ROS are essential for IH-induced elevation of arterial chemoreflex activation and sympathetic outflow, which may, in turn, contribute to IH-induced hypertension.

Original languageEnglish
Pages (from-to)70-79
Number of pages10
JournalRespiratory Physiology and Neurobiology
Issue number1
Publication statusPublished - Jan 31 2011



  • Arterial chemoreflex
  • Hypertension
  • Intermittent hypoxia
  • Reactive oxygen species
  • Sympathetic outflow

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)

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