RC-RNase-induced cell death in estrogen receptor positive breast tumors through down-regulation of Bcl-2 and estrogen receptor

Hsu Hung Tseng, Yung Luen Yu, Yi Lin Sophia Chen, Jia Hui Chen, Chu Lin Chou, Tsun Yung Kuo, Jaang Jiun Wang, Ming Chieh Lee, Ting Han Huang, Mark Hung Chih Chen, Giou Teng Yiang

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10 Citations (Scopus)

Abstract

RC-RNase exerts anti-cancer effects on many tumors. However, the mechanisms by which RC-RNase induces cytotoxicity in different tumor cells are unclear. Currently, estrogen receptor (ER)-positive and negative breast tumors are treated with RC-RNase. Our data demonstrate that RC-RNase induces cell death on ER-positive but not on ER-negative breast tumors. This study also shows that downregulation of ER and Bcl-2 is found on RC-RNase-treated ER-positive breast tumors. Additionally, Bcl-2 ovexpression can prevent ER-positive breast tumors from cell death treated with RC-RNase. In summary, this study demonstrates that RC-RNase-induced cell death of ER-positive breast tumors is through regulation of ER and Bcl-2.

Original languageEnglish
Pages (from-to)849-853
Number of pages5
JournalOncology Reports
Volume25
Issue number3
DOIs
Publication statusPublished - Mar 1 2011
Externally publishedYes

Keywords

  • Bcl-2
  • Breast tumor
  • Estrogen receptor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Tseng, H. H., Yu, Y. L., Chen, Y. L. S., Chen, J. H., Chou, C. L., Kuo, T. Y., Wang, J. J., Lee, M. C., Huang, T. H., Chen, M. H. C., & Yiang, G. T. (2011). RC-RNase-induced cell death in estrogen receptor positive breast tumors through down-regulation of Bcl-2 and estrogen receptor. Oncology Reports, 25(3), 849-853. https://doi.org/10.3892/or.2010.1114