Abstract

Objective: n-3 and n-6 polyunsaturated fatty acids (PUFAs) are essential nutrients in the human diet and possibly affect muscle mass. We evaluated the association between the dietary ratios of n-3 and n-6 PUFAs and muscle mass, indicated as skeletal muscle mass (SMM) and appendicular skeletal muscle mass (ASM), in patients with diabetes undergoing hemodialysis (HD). Methods: In this cross-sectional study, data on 69 patients with diabetes who underwent standard HD therapy were analyzed. For estimating muscle mass, anthropometric and bioelectrical impedance analyses were conducted following dialysis. In addition, routine laboratory and 3-d dietary data were obtained. The adequate intake (AI) cut-off for n-3 PUFAs was 1.6 g/d and 1.1 g/d for male and female patients, respectively. Results: The average age of the participants was 63.0 ± 10.4 y. The mean ratios of n-3/n-6 PUFA intake, n-6/n-3 PUFA intake, SMM, and ASM of the patients were 0.13 ± 0.07, 9.4 ± 6.4, 24.6 ± 5.4 kg, and 18.3 ± 4.6 kg, respectively. Patients who had AI of n-3 PUFAs had significantly higher SMM and ASM than did their counterparts. Linear and stepwise multivariable adjustment analyses revealed that insulin resistance and the n-6/n-3 PUFA ratio were the independent deleterious determinants of ASM normalized to height in HD patients. Conclusions: Patients with AI of n-3 PUFAs had total-body SMM and ASM that were more appropriate. A higher dietary ratio of n-6/n-3 PUFAs was associated with reduced muscle mass in HD patients.

Original languageEnglish
Pages (from-to)989-994
JournalNutrition
DOIs
Publication statusAccepted/In press - Oct 27 2015

Fingerprint

Renal Dialysis
Skeletal Muscle
Omega-3 Fatty Acids
Muscles
Unsaturated Fatty Acids
Electric Impedance
Insulin Resistance
Dialysis
Cross-Sectional Studies
Diet
Food

Keywords

  • Appendicular skeletal muscle mass
  • Diabetes
  • Hemodialysis
  • Polyunsaturated fatty acids
  • Skeletal muscle mass

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Ratio of dietary ω-3 and ω-6 fatty acids—independent determinants of muscle mass—in hemodialysis patients with diabetes. / Wong, Te Chih; Chen, Yu Tong; Wu, Pei Yu; Chen, Tzen Wen; Chen, Hsi Hsien; Chen, Tso Hsiao; Hsu, Yung Ho; Yang, Shwu Huey.

In: Nutrition, 27.10.2015, p. 989-994.

Research output: Contribution to journalArticle

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abstract = "Objective: n-3 and n-6 polyunsaturated fatty acids (PUFAs) are essential nutrients in the human diet and possibly affect muscle mass. We evaluated the association between the dietary ratios of n-3 and n-6 PUFAs and muscle mass, indicated as skeletal muscle mass (SMM) and appendicular skeletal muscle mass (ASM), in patients with diabetes undergoing hemodialysis (HD). Methods: In this cross-sectional study, data on 69 patients with diabetes who underwent standard HD therapy were analyzed. For estimating muscle mass, anthropometric and bioelectrical impedance analyses were conducted following dialysis. In addition, routine laboratory and 3-d dietary data were obtained. The adequate intake (AI) cut-off for n-3 PUFAs was 1.6 g/d and 1.1 g/d for male and female patients, respectively. Results: The average age of the participants was 63.0 ± 10.4 y. The mean ratios of n-3/n-6 PUFA intake, n-6/n-3 PUFA intake, SMM, and ASM of the patients were 0.13 ± 0.07, 9.4 ± 6.4, 24.6 ± 5.4 kg, and 18.3 ± 4.6 kg, respectively. Patients who had AI of n-3 PUFAs had significantly higher SMM and ASM than did their counterparts. Linear and stepwise multivariable adjustment analyses revealed that insulin resistance and the n-6/n-3 PUFA ratio were the independent deleterious determinants of ASM normalized to height in HD patients. Conclusions: Patients with AI of n-3 PUFAs had total-body SMM and ASM that were more appropriate. A higher dietary ratio of n-6/n-3 PUFAs was associated with reduced muscle mass in HD patients.",
keywords = "Appendicular skeletal muscle mass, Diabetes, Hemodialysis, Polyunsaturated fatty acids, Skeletal muscle mass",
author = "Wong, {Te Chih} and Chen, {Yu Tong} and Wu, {Pei Yu} and Chen, {Tzen Wen} and Chen, {Hsi Hsien} and Chen, {Tso Hsiao} and Hsu, {Yung Ho} and Yang, {Shwu Huey}",
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T1 - Ratio of dietary ω-3 and ω-6 fatty acids—independent determinants of muscle mass—in hemodialysis patients with diabetes

AU - Wong, Te Chih

AU - Chen, Yu Tong

AU - Wu, Pei Yu

AU - Chen, Tzen Wen

AU - Chen, Hsi Hsien

AU - Chen, Tso Hsiao

AU - Hsu, Yung Ho

AU - Yang, Shwu Huey

PY - 2015/10/27

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N2 - Objective: n-3 and n-6 polyunsaturated fatty acids (PUFAs) are essential nutrients in the human diet and possibly affect muscle mass. We evaluated the association between the dietary ratios of n-3 and n-6 PUFAs and muscle mass, indicated as skeletal muscle mass (SMM) and appendicular skeletal muscle mass (ASM), in patients with diabetes undergoing hemodialysis (HD). Methods: In this cross-sectional study, data on 69 patients with diabetes who underwent standard HD therapy were analyzed. For estimating muscle mass, anthropometric and bioelectrical impedance analyses were conducted following dialysis. In addition, routine laboratory and 3-d dietary data were obtained. The adequate intake (AI) cut-off for n-3 PUFAs was 1.6 g/d and 1.1 g/d for male and female patients, respectively. Results: The average age of the participants was 63.0 ± 10.4 y. The mean ratios of n-3/n-6 PUFA intake, n-6/n-3 PUFA intake, SMM, and ASM of the patients were 0.13 ± 0.07, 9.4 ± 6.4, 24.6 ± 5.4 kg, and 18.3 ± 4.6 kg, respectively. Patients who had AI of n-3 PUFAs had significantly higher SMM and ASM than did their counterparts. Linear and stepwise multivariable adjustment analyses revealed that insulin resistance and the n-6/n-3 PUFA ratio were the independent deleterious determinants of ASM normalized to height in HD patients. Conclusions: Patients with AI of n-3 PUFAs had total-body SMM and ASM that were more appropriate. A higher dietary ratio of n-6/n-3 PUFAs was associated with reduced muscle mass in HD patients.

AB - Objective: n-3 and n-6 polyunsaturated fatty acids (PUFAs) are essential nutrients in the human diet and possibly affect muscle mass. We evaluated the association between the dietary ratios of n-3 and n-6 PUFAs and muscle mass, indicated as skeletal muscle mass (SMM) and appendicular skeletal muscle mass (ASM), in patients with diabetes undergoing hemodialysis (HD). Methods: In this cross-sectional study, data on 69 patients with diabetes who underwent standard HD therapy were analyzed. For estimating muscle mass, anthropometric and bioelectrical impedance analyses were conducted following dialysis. In addition, routine laboratory and 3-d dietary data were obtained. The adequate intake (AI) cut-off for n-3 PUFAs was 1.6 g/d and 1.1 g/d for male and female patients, respectively. Results: The average age of the participants was 63.0 ± 10.4 y. The mean ratios of n-3/n-6 PUFA intake, n-6/n-3 PUFA intake, SMM, and ASM of the patients were 0.13 ± 0.07, 9.4 ± 6.4, 24.6 ± 5.4 kg, and 18.3 ± 4.6 kg, respectively. Patients who had AI of n-3 PUFAs had significantly higher SMM and ASM than did their counterparts. Linear and stepwise multivariable adjustment analyses revealed that insulin resistance and the n-6/n-3 PUFA ratio were the independent deleterious determinants of ASM normalized to height in HD patients. Conclusions: Patients with AI of n-3 PUFAs had total-body SMM and ASM that were more appropriate. A higher dietary ratio of n-6/n-3 PUFAs was associated with reduced muscle mass in HD patients.

KW - Appendicular skeletal muscle mass

KW - Diabetes

KW - Hemodialysis

KW - Polyunsaturated fatty acids

KW - Skeletal muscle mass

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