Abstract

Recent studies have indicated that the ratio of C-reactive protein to albumin (CRP-Alb ratio) is associated with clinical outcomes in patients with disease. We examined the predictive value of this ratio in patients undergoing hemodialysis (HD). In this cross-sectional study, 91 eligible adult HD patients were analyzed, and the correlation between the CRP-Alb ratio and skeletal muscle mass normalized for body weight (SMM/wt; estimated using a bioelectrical impedance analyzer) was investigated. The mean age of the study participants was 54.9 ± 6.6 years (ranging from 27 to 64 years); 43 (47.2%) were men. The mean values for the SMM/wt were 39.1% ± 5.4%. The CRP-Alb ratio was found to be negatively correlated with SMM/wt (r = -0.33, P = 0.002) and creatinine (r = -0.20, P = 0.056). All the univariate significant and nonsignificant relevant covariates were selected for multivariable stepwise regression analysis. We determined that the homeostasis model assessmentestimated insulin resistance and CRP-Alb ratio were independent risk determinants for SMM/wt (βHOMA-IR = -0.18 and βCRP-Alb ratio = -3.84, adjusted R2 = 0.32). This study indicated that the CRP-Alb ratio may help clinicians in predicting muscle mass in adult patients undergoing HD.

Original languageEnglish
Article numbere0165403
JournalPLoS One
Volume11
Issue number10
DOIs
Publication statusPublished - Oct 1 2016

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hemodialysis
C-reactive protein
C-Reactive Protein
albumins
Renal Dialysis
Muscle
Albumins
Muscles
muscles
Acoustic impedance
Regression analysis
Creatinine
Insulin
bioelectrical impedance
Electric Impedance
insulin resistance
cross-sectional studies
creatinine
skeletal muscle
Insulin Resistance

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Ratio of C-reactive protein to albumin predicts muscle mass in adult patients undergoing hemodialysis. / Wong, Te Chih; Su, Hsiu Yueh; Chen, Yu Tong; Wu, Pei Yu; Chen, Hsi Hsien; Chen, Tso Hsiao; Hsu, Yung Ho; Yang, Shwu Huey.

In: PLoS One, Vol. 11, No. 10, e0165403, 01.10.2016.

Research output: Contribution to journalArticle

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AU - Chen, Tso Hsiao

AU - Hsu, Yung Ho

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