Ras and Wnt interaction contribute in prostate cancer bone metastasis

Shian Ren Lin, Ntlotlang Mokgautsi, Yen Nien Liu

Research output: Contribution to journalReview article

Abstract

Prostate cancer (PCa) is one of the most prevalent and malignant cancer types in men, which causes more than three-hundred thousand cancer death each year. At late stage of PCa progression, bone marrow is the most often metastatic site that constitutes almost 70% of metastatic cases of the PCa population. However, the characteristic for the osteo-philic property of PCa is still puzzling. Recent studies reported that the Wnt and Ras signaling pathways are pivotal in bone metastasis and that take parts in different cytological changes, but their crosstalk is not well studied. In this review, we focused on interactions between the Wnt and Ras signaling pathways during each stage of bone metastasis and present the fate of those interactions. This review contributes insights that can guide other researchers by unveiling more details with regard to bone metastasis and might also help in finding potential therapeutic regimens for preventing PCa bone metastasis.

Original languageEnglish
Article number2380
JournalMolecules
Volume25
Issue number10
DOIs
Publication statusPublished - May 2020

Keywords

  • Bone metastasis
  • Cross reaction
  • Prostate cancer
  • Ras
  • Wnt

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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