Rapidly in situ forming hydrophobically-modified chitosan hydrogels via pH-responsive nanostructure transformation

Ya Ling Chiu, Mei Chin Chen, Chun Yu Chen, Po Wei Lee, Fwu Long Mi, U. Ser Jeng, Hsin Lung Chen, Hsing Wen Sung

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

A pH-responsive hydrogel targeted for various biomedical applications has been developed using a naturally-abundant biopolymer, chitosan, with controlled grafting of hydrophobic side chains. The rapid hydrogelation is driven by a transformation of the nanostructure of the side-chain aggregates from local micelles to interconnected nanodomains in a sponge phase due to the dominance of hydrophobic interaction near physiological pH.

Original languageEnglish
Pages (from-to)962-965
Number of pages4
JournalSoft Matter
Volume5
Issue number5
DOIs
Publication statusPublished - 2009
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

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