Rapid transformation of protein-caged nanomaterials into microbubbles as bimodal imaging agents

Cheng An J Lin, Wen Kai Chuang, Zih Yun Huang, Shih Tsung Kang, Ching Yi Chang, Ching Ta Chen, Jhih Liang Li, Jimmy K. Li, Hsueh Hsiao Wang, Fu Chen Kung, Ji Lin Shen, Wen Hsiung Chan, Chih Kuang Yeh, Hung I. Yeh, Wen Fu T Lai, Walter H. Chang

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Figure Persented: We present a general method for converting colloidal nanomaterials into microbubbles as ultrasound contrast agents. Protein-caged nanomaterials, made either by self-assembled nanoparticles' protein corona or by fluorescent gold nanoclusters, can be rapidly transformed into microbubbles via a sonochemical route, which promote disulfide cross-linking of cysteine residues between protein-caged nanomaterials and free albumin during acoustic cavitation. The proposed methods yielded microbubbles with multiple functions by adjusting the original nanoparticle/protein mixture. We also showed a new dual-modal imaging agent of fluorescent gold microbubbles in vitro and in vivo, which can hold many potential applications in medical diagnostics and therapy.

Original languageEnglish
Pages (from-to)5111-5121
Number of pages11
JournalACS Nano
Volume6
Issue number6
DOIs
Publication statusPublished - Jun 26 2012

Fingerprint

Nanostructured materials
proteins
Proteins
Imaging techniques
Gold
Nanoparticles
Nanoclusters
gold
Fluorescent Dyes
Cavitation
Disulfides
nanoparticles
Contrast Media
Cysteine
Albumins
cysteine
disulfides
cavitation flow
nanoclusters
Ultrasonics

Keywords

  • bimodal imaging
  • fluorescent gold nanoclusters
  • microbubbles
  • protein corona
  • quantum dots
  • ultrasound

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)
  • Physics and Astronomy(all)

Cite this

Lin, C. A. J., Chuang, W. K., Huang, Z. Y., Kang, S. T., Chang, C. Y., Chen, C. T., ... Chang, W. H. (2012). Rapid transformation of protein-caged nanomaterials into microbubbles as bimodal imaging agents. ACS Nano, 6(6), 5111-5121. https://doi.org/10.1021/nn300768d

Rapid transformation of protein-caged nanomaterials into microbubbles as bimodal imaging agents. / Lin, Cheng An J; Chuang, Wen Kai; Huang, Zih Yun; Kang, Shih Tsung; Chang, Ching Yi; Chen, Ching Ta; Li, Jhih Liang; Li, Jimmy K.; Wang, Hsueh Hsiao; Kung, Fu Chen; Shen, Ji Lin; Chan, Wen Hsiung; Yeh, Chih Kuang; Yeh, Hung I.; Lai, Wen Fu T; Chang, Walter H.

In: ACS Nano, Vol. 6, No. 6, 26.06.2012, p. 5111-5121.

Research output: Contribution to journalArticle

Lin, CAJ, Chuang, WK, Huang, ZY, Kang, ST, Chang, CY, Chen, CT, Li, JL, Li, JK, Wang, HH, Kung, FC, Shen, JL, Chan, WH, Yeh, CK, Yeh, HI, Lai, WFT & Chang, WH 2012, 'Rapid transformation of protein-caged nanomaterials into microbubbles as bimodal imaging agents', ACS Nano, vol. 6, no. 6, pp. 5111-5121. https://doi.org/10.1021/nn300768d
Lin CAJ, Chuang WK, Huang ZY, Kang ST, Chang CY, Chen CT et al. Rapid transformation of protein-caged nanomaterials into microbubbles as bimodal imaging agents. ACS Nano. 2012 Jun 26;6(6):5111-5121. https://doi.org/10.1021/nn300768d
Lin, Cheng An J ; Chuang, Wen Kai ; Huang, Zih Yun ; Kang, Shih Tsung ; Chang, Ching Yi ; Chen, Ching Ta ; Li, Jhih Liang ; Li, Jimmy K. ; Wang, Hsueh Hsiao ; Kung, Fu Chen ; Shen, Ji Lin ; Chan, Wen Hsiung ; Yeh, Chih Kuang ; Yeh, Hung I. ; Lai, Wen Fu T ; Chang, Walter H. / Rapid transformation of protein-caged nanomaterials into microbubbles as bimodal imaging agents. In: ACS Nano. 2012 ; Vol. 6, No. 6. pp. 5111-5121.
@article{38246520fdf74ee496a123d9dd6a3470,
title = "Rapid transformation of protein-caged nanomaterials into microbubbles as bimodal imaging agents",
abstract = "Figure Persented: We present a general method for converting colloidal nanomaterials into microbubbles as ultrasound contrast agents. Protein-caged nanomaterials, made either by self-assembled nanoparticles' protein corona or by fluorescent gold nanoclusters, can be rapidly transformed into microbubbles via a sonochemical route, which promote disulfide cross-linking of cysteine residues between protein-caged nanomaterials and free albumin during acoustic cavitation. The proposed methods yielded microbubbles with multiple functions by adjusting the original nanoparticle/protein mixture. We also showed a new dual-modal imaging agent of fluorescent gold microbubbles in vitro and in vivo, which can hold many potential applications in medical diagnostics and therapy.",
keywords = "bimodal imaging, fluorescent gold nanoclusters, microbubbles, protein corona, quantum dots, ultrasound",
author = "Lin, {Cheng An J} and Chuang, {Wen Kai} and Huang, {Zih Yun} and Kang, {Shih Tsung} and Chang, {Ching Yi} and Chen, {Ching Ta} and Li, {Jhih Liang} and Li, {Jimmy K.} and Wang, {Hsueh Hsiao} and Kung, {Fu Chen} and Shen, {Ji Lin} and Chan, {Wen Hsiung} and Yeh, {Chih Kuang} and Yeh, {Hung I.} and Lai, {Wen Fu T} and Chang, {Walter H.}",
year = "2012",
month = "6",
day = "26",
doi = "10.1021/nn300768d",
language = "English",
volume = "6",
pages = "5111--5121",
journal = "ACS Nano",
issn = "1936-0851",
publisher = "American Chemical Society",
number = "6",

}

TY - JOUR

T1 - Rapid transformation of protein-caged nanomaterials into microbubbles as bimodal imaging agents

AU - Lin, Cheng An J

AU - Chuang, Wen Kai

AU - Huang, Zih Yun

AU - Kang, Shih Tsung

AU - Chang, Ching Yi

AU - Chen, Ching Ta

AU - Li, Jhih Liang

AU - Li, Jimmy K.

AU - Wang, Hsueh Hsiao

AU - Kung, Fu Chen

AU - Shen, Ji Lin

AU - Chan, Wen Hsiung

AU - Yeh, Chih Kuang

AU - Yeh, Hung I.

AU - Lai, Wen Fu T

AU - Chang, Walter H.

PY - 2012/6/26

Y1 - 2012/6/26

N2 - Figure Persented: We present a general method for converting colloidal nanomaterials into microbubbles as ultrasound contrast agents. Protein-caged nanomaterials, made either by self-assembled nanoparticles' protein corona or by fluorescent gold nanoclusters, can be rapidly transformed into microbubbles via a sonochemical route, which promote disulfide cross-linking of cysteine residues between protein-caged nanomaterials and free albumin during acoustic cavitation. The proposed methods yielded microbubbles with multiple functions by adjusting the original nanoparticle/protein mixture. We also showed a new dual-modal imaging agent of fluorescent gold microbubbles in vitro and in vivo, which can hold many potential applications in medical diagnostics and therapy.

AB - Figure Persented: We present a general method for converting colloidal nanomaterials into microbubbles as ultrasound contrast agents. Protein-caged nanomaterials, made either by self-assembled nanoparticles' protein corona or by fluorescent gold nanoclusters, can be rapidly transformed into microbubbles via a sonochemical route, which promote disulfide cross-linking of cysteine residues between protein-caged nanomaterials and free albumin during acoustic cavitation. The proposed methods yielded microbubbles with multiple functions by adjusting the original nanoparticle/protein mixture. We also showed a new dual-modal imaging agent of fluorescent gold microbubbles in vitro and in vivo, which can hold many potential applications in medical diagnostics and therapy.

KW - bimodal imaging

KW - fluorescent gold nanoclusters

KW - microbubbles

KW - protein corona

KW - quantum dots

KW - ultrasound

UR - http://www.scopus.com/inward/record.url?scp=84862875191&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862875191&partnerID=8YFLogxK

U2 - 10.1021/nn300768d

DO - 10.1021/nn300768d

M3 - Article

VL - 6

SP - 5111

EP - 5121

JO - ACS Nano

JF - ACS Nano

SN - 1936-0851

IS - 6

ER -