Rapid recurrence and transformation of verrucous carcinoma of lower lip

Chin-Ta Lin, Shyi-Gen Chen, Tim-Mo Chen, Shun-Cheng Chang

Research output: Contribution to journalArticle

Abstract

We report a 52-year-old male with recurrent verrucous carcinoma of lower lip and rapid transformation into squamous cell carcinomas (SCC) three years after surgery. To date, verrucous carcinoma has been regarded as a variant of welldifferentiated SCC, which sometimes shows invasive changes but rarely metastasizes. With this case, we highlight the possibility of early recurrence and rapid transformation into SCC and emphasize the need for surgical resection with adequate margins. To our knowledge, such rapid transformation into SCC merely three months after surgery has never been reported in the literature. © 2012 JMS.
Original languageEnglish
Pages (from-to)301-303
Number of pages3
JournalJournal of Medical Sciences (Taiwan)
Volume32
Issue number6
Publication statusPublished - 2012
Externally publishedYes

Fingerprint

Verrucous Carcinoma
Lip
Squamous Cell Carcinoma
Recurrence

Keywords

  • Recurrence
  • Squamous cell carcinoma
  • Transformation
  • Verrucous carcinoma
  • Wide excision
  • adult
  • article
  • cancer recurrence
  • cancer surgery
  • carbon dioxide laser
  • case report
  • follow up
  • full thickness skin graft
  • histology
  • hospital discharge
  • human
  • human tissue
  • lip biopsy
  • lip carcinoma
  • lower lip
  • male
  • malignant transformation
  • medical history
  • smoking
  • verrucous carcinoma

Cite this

Rapid recurrence and transformation of verrucous carcinoma of lower lip. / Lin, Chin-Ta; Chen, Shyi-Gen; Chen, Tim-Mo; Chang, Shun-Cheng.

In: Journal of Medical Sciences (Taiwan), Vol. 32, No. 6, 2012, p. 301-303.

Research output: Contribution to journalArticle

Lin, Chin-Ta ; Chen, Shyi-Gen ; Chen, Tim-Mo ; Chang, Shun-Cheng. / Rapid recurrence and transformation of verrucous carcinoma of lower lip. In: Journal of Medical Sciences (Taiwan). 2012 ; Vol. 32, No. 6. pp. 301-303.
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abstract = "We report a 52-year-old male with recurrent verrucous carcinoma of lower lip and rapid transformation into squamous cell carcinomas (SCC) three years after surgery. To date, verrucous carcinoma has been regarded as a variant of welldifferentiated SCC, which sometimes shows invasive changes but rarely metastasizes. With this case, we highlight the possibility of early recurrence and rapid transformation into SCC and emphasize the need for surgical resection with adequate margins. To our knowledge, such rapid transformation into SCC merely three months after surgery has never been reported in the literature. {\circledC} 2012 JMS.",
keywords = "Recurrence, Squamous cell carcinoma, Transformation, Verrucous carcinoma, Wide excision, adult, article, cancer recurrence, cancer surgery, carbon dioxide laser, case report, follow up, full thickness skin graft, histology, hospital discharge, human, human tissue, lip biopsy, lip carcinoma, lower lip, male, malignant transformation, medical history, smoking, verrucous carcinoma",
author = "Chin-Ta Lin and Shyi-Gen Chen and Tim-Mo Chen and Shun-Cheng Chang",
note = "Export Date: 21 March 2016 通訊地址: Chang, S.-C.; Division of Plastic and Reconstructive Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Cheng-gong Road, Taipei 114, Taiwan; 電子郵件: aarondakimo@yahoo.com.tw 參考文獻: Ackerman, L.V., Verrucous carcinoma of the oral cavity (1948) Surgery, 23, pp. 670-678; Hemmer, J., Kraft, K., High-resolution DNA flow cytometry in oral verrucous carcinoma (2000) Oncol Rep, 7, pp. 433-435; Salesiotis, A., Soong, R., Diasio, R.B., Frost, A., Cullen, K.J., Capecitabine induces rapid, sustained response in two patients with extensive oral verrucous carcinoma (2003) Clin Cancer Res, 9, pp. 580-585; Pereira, M.C., Oliveira, D.T., Landman, G., Kowalski, L.P., Histologic subtypes of oral squamous cell carcinoma: Prognostic relevance (2007) J Can Dent Assoc, 73, pp. 339-344; Koch, B.B., Trask, D.K., Hoffman, H.T., Karnell, L.H., Robinson, R.A., Zhen, W., Menck, H.R., National survey of head and neck verrucous carcinoma: Patterns of presentation, care, and outcome (2001) Cancer, 92, pp. 110-120; Mirbod, S.M., Ahing, S.I., Tobacco-associated lesions of the oral cavity (2000) J Can Dent Assoc, 66, pp. 308-311. , Part II. Malignant lesions; Noble-Topham, S.E., Fliss, D.M., Hartwick, R.W., McLachlin, C.M., Freeman, J.L., Noyek, A.M., Andrulis, I.L., Detection and typing of human papillomavirus in verrucous carcinoma of the oral cavity using the polymerase chain reaction (1993) Arch Otolaryngol Head Neck Surg, 119, pp. 1299-1304; Saito, T., Nakajima, T., Mogi, K., Immunohistochemical analysis of cell cycle associated proteins p16, pRb, p53, p27 and Ki-67 in oral cancer and precancer with special reference to verrucous carcinomas (1999) J Oral Pathol Med, 28, pp. 226-232; Ferlito, A., Devaney, K.O., Rinaldo, A., Putzi, M.J., Papillary squamous cell carcinoma versus verrucous squamous cell carcinoma of the head and neck (1999) Ann Otol Rhinol Laryngol, 108, pp. 318-322; Spiro, R.H., Verrucous carcinoma, then and now (1998) Am J Surg, 176, pp. 393-397; Anderson, M., Muro-Cacho, C., Cordero, J., Livingston, S., Mu{\~n}oz-Antonia, T., Transforming growth factor beta receptors in verrucous and squamous cell carcinoma (1999) Arch Otolaryngol Head Neck Surg, 125, pp. 849-854; Medina, J.E., Dichtel, W., Luna, M.A., Verrucous-squamous carcinomas of the oral cavity: A clinicopathologic study of 104 cases (1984) Arch Otolaryngol, 110, pp. 437-440; Perez, C.A., Kraus, F.T., Evans, J.C., Powers, W.E., Anaplastic transformation in verrucous carcinoma of the oral cavity after radiation therapy (1966) Radiology, 86, pp. 108-115; Oliveira, D.T., de Moraes, R.V., Fiamengui Filho, J.F., Fanton Neto, J., Landman, G., Kowalski, L.P., Oral verrucous carcinoma: A retrospective study in Sao Paulo Region, Brazil (2006) Clin Oral Invest, 10, pp. 205-209",
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TY - JOUR

T1 - Rapid recurrence and transformation of verrucous carcinoma of lower lip

AU - Lin, Chin-Ta

AU - Chen, Shyi-Gen

AU - Chen, Tim-Mo

AU - Chang, Shun-Cheng

N1 - Export Date: 21 March 2016 通訊地址: Chang, S.-C.; Division of Plastic and Reconstructive Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Cheng-gong Road, Taipei 114, Taiwan; 電子郵件: aarondakimo@yahoo.com.tw 參考文獻: Ackerman, L.V., Verrucous carcinoma of the oral cavity (1948) Surgery, 23, pp. 670-678; Hemmer, J., Kraft, K., High-resolution DNA flow cytometry in oral verrucous carcinoma (2000) Oncol Rep, 7, pp. 433-435; Salesiotis, A., Soong, R., Diasio, R.B., Frost, A., Cullen, K.J., Capecitabine induces rapid, sustained response in two patients with extensive oral verrucous carcinoma (2003) Clin Cancer Res, 9, pp. 580-585; Pereira, M.C., Oliveira, D.T., Landman, G., Kowalski, L.P., Histologic subtypes of oral squamous cell carcinoma: Prognostic relevance (2007) J Can Dent Assoc, 73, pp. 339-344; Koch, B.B., Trask, D.K., Hoffman, H.T., Karnell, L.H., Robinson, R.A., Zhen, W., Menck, H.R., National survey of head and neck verrucous carcinoma: Patterns of presentation, care, and outcome (2001) Cancer, 92, pp. 110-120; Mirbod, S.M., Ahing, S.I., Tobacco-associated lesions of the oral cavity (2000) J Can Dent Assoc, 66, pp. 308-311. , Part II. Malignant lesions; Noble-Topham, S.E., Fliss, D.M., Hartwick, R.W., McLachlin, C.M., Freeman, J.L., Noyek, A.M., Andrulis, I.L., Detection and typing of human papillomavirus in verrucous carcinoma of the oral cavity using the polymerase chain reaction (1993) Arch Otolaryngol Head Neck Surg, 119, pp. 1299-1304; Saito, T., Nakajima, T., Mogi, K., Immunohistochemical analysis of cell cycle associated proteins p16, pRb, p53, p27 and Ki-67 in oral cancer and precancer with special reference to verrucous carcinomas (1999) J Oral Pathol Med, 28, pp. 226-232; Ferlito, A., Devaney, K.O., Rinaldo, A., Putzi, M.J., Papillary squamous cell carcinoma versus verrucous squamous cell carcinoma of the head and neck (1999) Ann Otol Rhinol Laryngol, 108, pp. 318-322; Spiro, R.H., Verrucous carcinoma, then and now (1998) Am J Surg, 176, pp. 393-397; Anderson, M., Muro-Cacho, C., Cordero, J., Livingston, S., Muñoz-Antonia, T., Transforming growth factor beta receptors in verrucous and squamous cell carcinoma (1999) Arch Otolaryngol Head Neck Surg, 125, pp. 849-854; Medina, J.E., Dichtel, W., Luna, M.A., Verrucous-squamous carcinomas of the oral cavity: A clinicopathologic study of 104 cases (1984) Arch Otolaryngol, 110, pp. 437-440; Perez, C.A., Kraus, F.T., Evans, J.C., Powers, W.E., Anaplastic transformation in verrucous carcinoma of the oral cavity after radiation therapy (1966) Radiology, 86, pp. 108-115; Oliveira, D.T., de Moraes, R.V., Fiamengui Filho, J.F., Fanton Neto, J., Landman, G., Kowalski, L.P., Oral verrucous carcinoma: A retrospective study in Sao Paulo Region, Brazil (2006) Clin Oral Invest, 10, pp. 205-209

PY - 2012

Y1 - 2012

N2 - We report a 52-year-old male with recurrent verrucous carcinoma of lower lip and rapid transformation into squamous cell carcinomas (SCC) three years after surgery. To date, verrucous carcinoma has been regarded as a variant of welldifferentiated SCC, which sometimes shows invasive changes but rarely metastasizes. With this case, we highlight the possibility of early recurrence and rapid transformation into SCC and emphasize the need for surgical resection with adequate margins. To our knowledge, such rapid transformation into SCC merely three months after surgery has never been reported in the literature. © 2012 JMS.

AB - We report a 52-year-old male with recurrent verrucous carcinoma of lower lip and rapid transformation into squamous cell carcinomas (SCC) three years after surgery. To date, verrucous carcinoma has been regarded as a variant of welldifferentiated SCC, which sometimes shows invasive changes but rarely metastasizes. With this case, we highlight the possibility of early recurrence and rapid transformation into SCC and emphasize the need for surgical resection with adequate margins. To our knowledge, such rapid transformation into SCC merely three months after surgery has never been reported in the literature. © 2012 JMS.

KW - Recurrence

KW - Squamous cell carcinoma

KW - Transformation

KW - Verrucous carcinoma

KW - Wide excision

KW - adult

KW - article

KW - cancer recurrence

KW - cancer surgery

KW - carbon dioxide laser

KW - case report

KW - follow up

KW - full thickness skin graft

KW - histology

KW - hospital discharge

KW - human

KW - human tissue

KW - lip biopsy

KW - lip carcinoma

KW - lower lip

KW - male

KW - malignant transformation

KW - medical history

KW - smoking

KW - verrucous carcinoma

M3 - Article

VL - 32

SP - 301

EP - 303

JO - Journal of Medical Sciences

JF - Journal of Medical Sciences

SN - 1011-4564

IS - 6

ER -