Rapid recurrence and transformation of verrucous carcinoma of lower lip

Chin-Ta Lin, Shyi-Gen Chen, Tim-Mo Chen, Shun-Cheng Chang

Research output: Contribution to journalArticlepeer-review


We report a 52-year-old male with recurrent verrucous carcinoma of lower lip and rapid transformation into squamous cell carcinomas (SCC) three years after surgery. To date, verrucous carcinoma has been regarded as a variant of welldifferentiated SCC, which sometimes shows invasive changes but rarely metastasizes. With this case, we highlight the possibility of early recurrence and rapid transformation into SCC and emphasize the need for surgical resection with adequate margins. To our knowledge, such rapid transformation into SCC merely three months after surgery has never been reported in the literature. © 2012 JMS.
Original languageEnglish
Pages (from-to)301-303
Number of pages3
JournalJournal of Medical Sciences (Taiwan)
Issue number6
Publication statusPublished - 2012
Externally publishedYes


  • Recurrence
  • Squamous cell carcinoma
  • Transformation
  • Verrucous carcinoma
  • Wide excision
  • adult
  • article
  • cancer recurrence
  • cancer surgery
  • carbon dioxide laser
  • case report
  • follow up
  • full thickness skin graft
  • histology
  • hospital discharge
  • human
  • human tissue
  • lip biopsy
  • lip carcinoma
  • lower lip
  • male
  • malignant transformation
  • medical history
  • smoking
  • verrucous carcinoma


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