Rapid Osseointegration of Titanium Implant with Innovative Nanoporous Surface Modification: Animal Model and Clinical Trial

Mao Suan Huang, Li Kai Chen, Keng Liang Ou, Han Yi Cheng, Che Shun Wang

Research output: Contribution to journalArticle

11 Citations (Scopus)


Objectives: SLAffinity is the hybrid topography consisting of micropits and nanoporous TiO 2 layers through electrochemical oxidation to mimic the natural bony environment. The aim of this study was to examine the rate of osseointegration in animal models and to further investigate the stability for implants with SLAffinity-treated surface in the clinical trial. Materials and Methods: Implants were installed in the mandibular canine-premolar area of 12 miniature pigs. Each pig received 2 implants with the same shapes but with different chemical surfaces. In the clinical trial, 25 patients were included. Each patient received 1 SLAffinity-treated implant on the posterior area of either arch. Resonance frequency analysis and computed tomography were assessed weekly over the first 12 weeks after implant placement. Results: The results found that surface treatment did affect the bone-to-implant contact (BIC) significantly. Comparison of BIC at 3 weeks in animal study showed that the SLAffinity-treated implants presented significantly higher values than machine surface implants. SLAffinity-treated implants also proved clinically successful through 12 months, ready for prosthodontic restoration. Conclusion: The effect of SLAffinity treatments enhanced osseointegration significantly, especially at early stages of bone healing. Clinical trial finding, furthermore, ensured that the SLAffinity treatment was a reliable surface modification alternative. ©

Original languageEnglish
Pages (from-to)441-447
Number of pages7
JournalImplant Dentistry
Issue number4
Publication statusPublished - Aug 5 2015



  • clinical trial
  • dental implant
  • nanoporous surface modification
  • rapid osseointegration

ASJC Scopus subject areas

  • Oral Surgery

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