Rapid improvement of paraplegia caused by epidural involvements of Burkitt's lymphoma with chemotherapy.

Hiroshi Matsubara, Ken ichiro Watanabe, Hidemasa Sakai, Hsi Chang, Hisanori Fujino, Yuri Higashi, Michihiro Kobayashi, Souichi Adachi, Shiro Seto, Tatsutoshi Nakahata

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

STUDY DESIGN: Case report. OBJECTIVE: The authors present a case of atypical Burkitt's lymphoma with multiple epidural involvements. SUMMARY OF BACKGROUND DATA: Spinal cord compression in children is an emergency that requires urgent attention to minimize neurologic dysfunction. Although it is not life-threatening in most patients, cord compression can cause severe neurologic morbidity. MATERIALS AND METHODS: Because the patient showed rapid neurologic deterioration, we started chemotherapy and high-dose steroids without laminectomy or radiotherapy immediately after a tumor biopsy from the left mandible. RESULT: The combined therapies were very effective and his neurologic symptoms improved immediately. The epidural involved masses disappeared in imaging studies after the first course of chemotherapy including methylprednisolone (20 mg/kg per day for 3 consecutive days and gradually tapered off over 2 weeks), vincristine (1.5 mg/m2 per day), cyclophosphamide (2 g/m2 per day for 2 days) and pirarubicin (40 mg/m2 per day). After completing seven courses of chemotherapy, the patient is now fully ambulant. CONCLUSION: Considering the severe late effects of laminectomy and radiotherapy, chemotherapy should be considered as a first choice of treatment for spinal cord compression caused by malignant lymphoma.

Original languageEnglish
JournalSpine
Volume29
Issue number1
Publication statusPublished - Jan 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Orthopedics and Sports Medicine

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    Matsubara, H., Watanabe, K. I., Sakai, H., Chang, H., Fujino, H., Higashi, Y., Kobayashi, M., Adachi, S., Seto, S., & Nakahata, T. (2004). Rapid improvement of paraplegia caused by epidural involvements of Burkitt's lymphoma with chemotherapy. Spine, 29(1).