Rapid correction of metabolic acidosis in chronic renal failure: Effect on parathyroid hormone activity

K. C. Lu, S. D. Shieh, B. L. Li, P. Chu, S. Y. Jan, Y. F. Lin

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

To investigate the effect of rapid correction of chronic metabolic acidosis on circulating intact parathyroid hormone (I-PTH) activity by free calcium clamp in chronic renal failure, 18 patients were enrolled in this study. Metabolic acidosis was corrected by continuous bicarbonate infusion while plasma ionized calcium was clamped at the preinfusion level throughout the entire procedure. The plasma pH, bicarbonate, total CO2, sodium, serum total calcium and 1,25(OH)2 vitamin D3 levels increased significantly while serum concentrations of I-PTH, alkaline phosphatase and albumin showed significant decreases after bicarbonate infusion. The plasma ionized calcium, potassium, serum magnesium and inorganic phosphorus levels showed no significant difference before and after bicarbonate infusion. These results demonstrate that rapid correction of metabolic acidosis attenuates circulating PTH activity in chronic renal failure and may underline the importance of maintaining normal acid-base homeostasis particularly in the presence of secondary hyperparathyroidism.

Original languageEnglish
Pages (from-to)419-424
Number of pages6
JournalNephron
Volume67
Issue number4
Publication statusPublished - 1994
Externally publishedYes

Fingerprint

Bicarbonates
Acidosis
Parathyroid Hormone
Chronic Kidney Failure
Calcium
Serum
Secondary Hyperparathyroidism
Cholecalciferol
Phosphorus
Magnesium
Alkaline Phosphatase
Albumins
Potassium
Homeostasis
Sodium
Acids

Keywords

  • Chronic renal failure
  • Free calcium clamp
  • Metabolic acidosis
  • Secondary hyperparathyroidism

ASJC Scopus subject areas

  • Nephrology

Cite this

Lu, K. C., Shieh, S. D., Li, B. L., Chu, P., Jan, S. Y., & Lin, Y. F. (1994). Rapid correction of metabolic acidosis in chronic renal failure: Effect on parathyroid hormone activity. Nephron, 67(4), 419-424.

Rapid correction of metabolic acidosis in chronic renal failure : Effect on parathyroid hormone activity. / Lu, K. C.; Shieh, S. D.; Li, B. L.; Chu, P.; Jan, S. Y.; Lin, Y. F.

In: Nephron, Vol. 67, No. 4, 1994, p. 419-424.

Research output: Contribution to journalArticle

Lu, KC, Shieh, SD, Li, BL, Chu, P, Jan, SY & Lin, YF 1994, 'Rapid correction of metabolic acidosis in chronic renal failure: Effect on parathyroid hormone activity', Nephron, vol. 67, no. 4, pp. 419-424.
Lu, K. C. ; Shieh, S. D. ; Li, B. L. ; Chu, P. ; Jan, S. Y. ; Lin, Y. F. / Rapid correction of metabolic acidosis in chronic renal failure : Effect on parathyroid hormone activity. In: Nephron. 1994 ; Vol. 67, No. 4. pp. 419-424.
@article{0317c8ce4db64205881fc82a80686e46,
title = "Rapid correction of metabolic acidosis in chronic renal failure: Effect on parathyroid hormone activity",
abstract = "To investigate the effect of rapid correction of chronic metabolic acidosis on circulating intact parathyroid hormone (I-PTH) activity by free calcium clamp in chronic renal failure, 18 patients were enrolled in this study. Metabolic acidosis was corrected by continuous bicarbonate infusion while plasma ionized calcium was clamped at the preinfusion level throughout the entire procedure. The plasma pH, bicarbonate, total CO2, sodium, serum total calcium and 1,25(OH)2 vitamin D3 levels increased significantly while serum concentrations of I-PTH, alkaline phosphatase and albumin showed significant decreases after bicarbonate infusion. The plasma ionized calcium, potassium, serum magnesium and inorganic phosphorus levels showed no significant difference before and after bicarbonate infusion. These results demonstrate that rapid correction of metabolic acidosis attenuates circulating PTH activity in chronic renal failure and may underline the importance of maintaining normal acid-base homeostasis particularly in the presence of secondary hyperparathyroidism.",
keywords = "Chronic renal failure, Free calcium clamp, Metabolic acidosis, Secondary hyperparathyroidism",
author = "Lu, {K. C.} and Shieh, {S. D.} and Li, {B. L.} and P. Chu and Jan, {S. Y.} and Lin, {Y. F.}",
year = "1994",
language = "English",
volume = "67",
pages = "419--424",
journal = "Experimental Nephrology",
issn = "0028-2766",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - Rapid correction of metabolic acidosis in chronic renal failure

T2 - Effect on parathyroid hormone activity

AU - Lu, K. C.

AU - Shieh, S. D.

AU - Li, B. L.

AU - Chu, P.

AU - Jan, S. Y.

AU - Lin, Y. F.

PY - 1994

Y1 - 1994

N2 - To investigate the effect of rapid correction of chronic metabolic acidosis on circulating intact parathyroid hormone (I-PTH) activity by free calcium clamp in chronic renal failure, 18 patients were enrolled in this study. Metabolic acidosis was corrected by continuous bicarbonate infusion while plasma ionized calcium was clamped at the preinfusion level throughout the entire procedure. The plasma pH, bicarbonate, total CO2, sodium, serum total calcium and 1,25(OH)2 vitamin D3 levels increased significantly while serum concentrations of I-PTH, alkaline phosphatase and albumin showed significant decreases after bicarbonate infusion. The plasma ionized calcium, potassium, serum magnesium and inorganic phosphorus levels showed no significant difference before and after bicarbonate infusion. These results demonstrate that rapid correction of metabolic acidosis attenuates circulating PTH activity in chronic renal failure and may underline the importance of maintaining normal acid-base homeostasis particularly in the presence of secondary hyperparathyroidism.

AB - To investigate the effect of rapid correction of chronic metabolic acidosis on circulating intact parathyroid hormone (I-PTH) activity by free calcium clamp in chronic renal failure, 18 patients were enrolled in this study. Metabolic acidosis was corrected by continuous bicarbonate infusion while plasma ionized calcium was clamped at the preinfusion level throughout the entire procedure. The plasma pH, bicarbonate, total CO2, sodium, serum total calcium and 1,25(OH)2 vitamin D3 levels increased significantly while serum concentrations of I-PTH, alkaline phosphatase and albumin showed significant decreases after bicarbonate infusion. The plasma ionized calcium, potassium, serum magnesium and inorganic phosphorus levels showed no significant difference before and after bicarbonate infusion. These results demonstrate that rapid correction of metabolic acidosis attenuates circulating PTH activity in chronic renal failure and may underline the importance of maintaining normal acid-base homeostasis particularly in the presence of secondary hyperparathyroidism.

KW - Chronic renal failure

KW - Free calcium clamp

KW - Metabolic acidosis

KW - Secondary hyperparathyroidism

UR - http://www.scopus.com/inward/record.url?scp=0028206321&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028206321&partnerID=8YFLogxK

M3 - Article

C2 - 7969674

AN - SCOPUS:0028206321

VL - 67

SP - 419

EP - 424

JO - Experimental Nephrology

JF - Experimental Nephrology

SN - 0028-2766

IS - 4

ER -