Radiotherapy in the Management of Localized Classic Kaposi's Sarcoma

王 耀慶(Yao-Ching Wang), 丁 禮莉(Lai-Lei Ting), 簡 君儒(Chun-Ru Chien), 郭 頌鑫(Sung-Hsin Kuo), 黃 國明(Kuo-Ming Huang), 黃 昭源(Chao-Yuan Huang), 賴 明坤(Ming-Kuen Lai), 成 佳憲(Chia-Hsien Cheng)

Research output: Contribution to journalArticle

Abstract

Purpose: Classic Kaposi's sarcoma (CKS) is a prevalent indolent neoplasm among Eastern European and Mediterranean origin, but is rare in the other ethnic groups.Radiotherapy may provide symptom relief and tumor control in patients who have a few lesions in a limited area. This study was to assess the effectiveness of radiotherapy in the local control and the symptom relief of the CKS.Materials and Methods: Between August 1994 and November 2004, 48 patients with histologically proven Kaposi's sarcoma were selected for review from the Cancer Registry of National Taiwan University Hospital, eleven patients were both human immunodeficiency virus (HIV)-negative and non organ-transplant recipients. These patients received radiotherapy and were eligible for this study. Treatment methods consisted of local radiotherapy using Cobalt-60 teletherapy, megavoltage photon beam or electron beam. The treatment fields, fractionation, and total dose of radiation were determined on the clinical basis.
Results: A total of 11 patients (20 lesions) were enrolled into this study. There were 9 men and 2 women, with a mean age of 66 years. Median follow-up for surviving patients ranged from 4 to 44 months (median, 17 months). Target dose ranged from 30 Gy in ten fractions to 40 Gy in twenty fractions, with the exceptions in four lesions (2 patients). The complete response rate was 75% (15 lesions), and the partial response was evident in the remaining lesions. Median free from recurrence interval has not been reached. The 3-month, 6-month and 1.5-year local regional control rates were 95%, 74% and 74%, respectively. Symptom relief was achieved in all patients. Chronic complications including exudative dermatitis and variable degrees of edema were rare and mild.Conclusion: With the few late complication of mild edema and hyperpigmentation, local radiotherapy to CKS was well tolerated and effective. These data suggest that the local radiotherapy remains the effective treatment modality for non-HIV related localized classic Kaposi's sarcoma.
Original languageEnglish
Pages (from-to)199-206
Number of pages8
Journal放射治療與腫瘤學
Volume12
Issue number3
DOIs
Publication statusPublished - 2005
Externally publishedYes

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Kaposi's Sarcoma
Radiotherapy
Edema
Dose Fractionation
Neoplasms
Hyperpigmentation
Dermatitis
Cobalt
Taiwan
Photons
Ethnic Groups
Registries
Therapeutics
HIV
Electrons
Radiation
Viruses
Transplants
Recurrence

Keywords

  • 傳統性卡波西氏肉瘤
  • 放射線治療
  • 劑量
  • 治療反應
  • Classic Kaposi's sarcoma
  • Radiotherapy
  • Dose
  • Response

Cite this

王耀慶(Yao-Ching W, 丁禮莉(Lai-Lei T, 簡君儒(Chun-Ru C, 郭頌鑫(Sung-Hsin K, 黃國明(Kuo-Ming H, 黃昭源(Chao-Yuan H, ... 成佳憲(Chia-Hsien C (2005). Radiotherapy in the Management of Localized Classic Kaposi's Sarcoma. 放射治療與腫瘤學, 12(3), 199-206. https://doi.org/10.6316/TRO/200512

Radiotherapy in the Management of Localized Classic Kaposi's Sarcoma. / 王耀慶(Yao-Ching Wang); 丁禮莉(Lai-Lei Ting); 簡君儒(Chun-Ru Chien); 郭頌鑫(Sung-Hsin Kuo); 黃國明(Kuo-Ming Huang); 黃昭源(Chao-Yuan Huang); 賴明坤(Ming-Kuen Lai); 成佳憲(Chia-Hsien Cheng).

In: 放射治療與腫瘤學, Vol. 12, No. 3, 2005, p. 199-206.

Research output: Contribution to journalArticle

王耀慶(Yao-ChingW, 丁禮莉(Lai-LeiT, 簡君儒(Chun-RuC, 郭頌鑫(Sung-HsinK, 黃國明(Kuo-MingH, 黃昭源(Chao-YuanH, 賴明坤(Ming-KuenL & 成佳憲(Chia-HsienC 2005, 'Radiotherapy in the Management of Localized Classic Kaposi's Sarcoma', 放射治療與腫瘤學, vol. 12, no. 3, pp. 199-206. https://doi.org/10.6316/TRO/200512
王耀慶(Yao-ChingW, 丁禮莉(Lai-LeiT, 簡君儒(Chun-RuC, 郭頌鑫(Sung-HsinK, 黃國明(Kuo-MingH, 黃昭源(Chao-YuanH et al. Radiotherapy in the Management of Localized Classic Kaposi's Sarcoma. 放射治療與腫瘤學. 2005;12(3):199-206. https://doi.org/10.6316/TRO/200512
王耀慶(Yao-Ching Wang) ; 丁禮莉(Lai-Lei Ting) ; 簡君儒(Chun-Ru Chien) ; 郭頌鑫(Sung-Hsin Kuo) ; 黃國明(Kuo-Ming Huang) ; 黃昭源(Chao-Yuan Huang) ; 賴明坤(Ming-Kuen Lai) ; 成佳憲(Chia-Hsien Cheng). / Radiotherapy in the Management of Localized Classic Kaposi's Sarcoma. In: 放射治療與腫瘤學. 2005 ; Vol. 12, No. 3. pp. 199-206.
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abstract = "Purpose: Classic Kaposi's sarcoma (CKS) is a prevalent indolent neoplasm among Eastern European and Mediterranean origin, but is rare in the other ethnic groups.Radiotherapy may provide symptom relief and tumor control in patients who have a few lesions in a limited area. This study was to assess the effectiveness of radiotherapy in the local control and the symptom relief of the CKS.Materials and Methods: Between August 1994 and November 2004, 48 patients with histologically proven Kaposi's sarcoma were selected for review from the Cancer Registry of National Taiwan University Hospital, eleven patients were both human immunodeficiency virus (HIV)-negative and non organ-transplant recipients. These patients received radiotherapy and were eligible for this study. Treatment methods consisted of local radiotherapy using Cobalt-60 teletherapy, megavoltage photon beam or electron beam. The treatment fields, fractionation, and total dose of radiation were determined on the clinical basis.Results: A total of 11 patients (20 lesions) were enrolled into this study. There were 9 men and 2 women, with a mean age of 66 years. Median follow-up for surviving patients ranged from 4 to 44 months (median, 17 months). Target dose ranged from 30 Gy in ten fractions to 40 Gy in twenty fractions, with the exceptions in four lesions (2 patients). The complete response rate was 75{\%} (15 lesions), and the partial response was evident in the remaining lesions. Median free from recurrence interval has not been reached. The 3-month, 6-month and 1.5-year local regional control rates were 95{\%}, 74{\%} and 74{\%}, respectively. Symptom relief was achieved in all patients. Chronic complications including exudative dermatitis and variable degrees of edema were rare and mild.Conclusion: With the few late complication of mild edema and hyperpigmentation, local radiotherapy to CKS was well tolerated and effective. These data suggest that the local radiotherapy remains the effective treatment modality for non-HIV related localized classic Kaposi's sarcoma.",
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T1 - Radiotherapy in the Management of Localized Classic Kaposi's Sarcoma

AU - 王, 耀慶(Yao-Ching Wang)

AU - 丁, 禮莉(Lai-Lei Ting)

AU - 簡, 君儒(Chun-Ru Chien)

AU - 郭, 頌鑫(Sung-Hsin Kuo)

AU - 黃, 國明(Kuo-Ming Huang)

AU - 黃, 昭源(Chao-Yuan Huang)

AU - 賴, 明坤(Ming-Kuen Lai)

AU - 成, 佳憲(Chia-Hsien Cheng)

PY - 2005

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N2 - Purpose: Classic Kaposi's sarcoma (CKS) is a prevalent indolent neoplasm among Eastern European and Mediterranean origin, but is rare in the other ethnic groups.Radiotherapy may provide symptom relief and tumor control in patients who have a few lesions in a limited area. This study was to assess the effectiveness of radiotherapy in the local control and the symptom relief of the CKS.Materials and Methods: Between August 1994 and November 2004, 48 patients with histologically proven Kaposi's sarcoma were selected for review from the Cancer Registry of National Taiwan University Hospital, eleven patients were both human immunodeficiency virus (HIV)-negative and non organ-transplant recipients. These patients received radiotherapy and were eligible for this study. Treatment methods consisted of local radiotherapy using Cobalt-60 teletherapy, megavoltage photon beam or electron beam. The treatment fields, fractionation, and total dose of radiation were determined on the clinical basis.Results: A total of 11 patients (20 lesions) were enrolled into this study. There were 9 men and 2 women, with a mean age of 66 years. Median follow-up for surviving patients ranged from 4 to 44 months (median, 17 months). Target dose ranged from 30 Gy in ten fractions to 40 Gy in twenty fractions, with the exceptions in four lesions (2 patients). The complete response rate was 75% (15 lesions), and the partial response was evident in the remaining lesions. Median free from recurrence interval has not been reached. The 3-month, 6-month and 1.5-year local regional control rates were 95%, 74% and 74%, respectively. Symptom relief was achieved in all patients. Chronic complications including exudative dermatitis and variable degrees of edema were rare and mild.Conclusion: With the few late complication of mild edema and hyperpigmentation, local radiotherapy to CKS was well tolerated and effective. These data suggest that the local radiotherapy remains the effective treatment modality for non-HIV related localized classic Kaposi's sarcoma.

AB - Purpose: Classic Kaposi's sarcoma (CKS) is a prevalent indolent neoplasm among Eastern European and Mediterranean origin, but is rare in the other ethnic groups.Radiotherapy may provide symptom relief and tumor control in patients who have a few lesions in a limited area. This study was to assess the effectiveness of radiotherapy in the local control and the symptom relief of the CKS.Materials and Methods: Between August 1994 and November 2004, 48 patients with histologically proven Kaposi's sarcoma were selected for review from the Cancer Registry of National Taiwan University Hospital, eleven patients were both human immunodeficiency virus (HIV)-negative and non organ-transplant recipients. These patients received radiotherapy and were eligible for this study. Treatment methods consisted of local radiotherapy using Cobalt-60 teletherapy, megavoltage photon beam or electron beam. The treatment fields, fractionation, and total dose of radiation were determined on the clinical basis.Results: A total of 11 patients (20 lesions) were enrolled into this study. There were 9 men and 2 women, with a mean age of 66 years. Median follow-up for surviving patients ranged from 4 to 44 months (median, 17 months). Target dose ranged from 30 Gy in ten fractions to 40 Gy in twenty fractions, with the exceptions in four lesions (2 patients). The complete response rate was 75% (15 lesions), and the partial response was evident in the remaining lesions. Median free from recurrence interval has not been reached. The 3-month, 6-month and 1.5-year local regional control rates were 95%, 74% and 74%, respectively. Symptom relief was achieved in all patients. Chronic complications including exudative dermatitis and variable degrees of edema were rare and mild.Conclusion: With the few late complication of mild edema and hyperpigmentation, local radiotherapy to CKS was well tolerated and effective. These data suggest that the local radiotherapy remains the effective treatment modality for non-HIV related localized classic Kaposi's sarcoma.

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KW - 放射線治療

KW - 劑量

KW - 治療反應

KW - Classic Kaposi's sarcoma

KW - Radiotherapy

KW - Dose

KW - Response

KW - Classic Kaposi’s sarcoma

KW - Radiotherapy

KW - Dose

KW - Response

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M3 - Article

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JO - 放射治療與腫瘤學

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