Radiosurgery for dural carotid-cavernous sinus fistulas

Gamma Knife compared with XKnife radiosurgery.

Hung Chuan Pan, Ming Hsi Sun, Jason Sheehan, Meei Ling Sheu, Clayton Chi Chang Chen, Hsu Tung Lee, Wen Ta Chiu, Dar Yu Yang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In the modern era, stereotactic radiosurgery is an important part of the multidisciplinary and multimodality approach used to treat dural carotid-cavernous fistulas (DCCFs). Based on the ease of performance of techniques to fuse cerebral angiography studies with MR images or CT scans during the radiosurgical procedure, the Gamma Knife and XKnife are 2 of the most popular radiosurgical instruments for patients with DCCF. In this study, the authors compared the efficacy, neurological results, and complications associated with these 2 radiosurgical devices when used for DCCF. Records for 41 patients with DCCF (15 treated using the XKnife and 26 with Gamma Knife surgery [GKS]) were retrieved from a radiosurgical database encompassing the period of September 2000 to August 2008. Among these patients, at least 2 consecutive MR imaging or MR angiography studies obtained after radiosurgery were available for determining radiological outcome of the fistula. All patients received regular follow-up to evaluate the neurological and ophthalmological function at an interval of 1-3 months. The symptomatology, obliteration rate, radiation dose, instrument accuracy, and adverse effects were determined for each group and compared between 2 groups. The data were analyzed using the Student t-test. The mean age of the patients was 63 ± 2.6 years, and the mean follow-up period was 63.1 ± 4.4 months (mean ± SD). Thirty-seven patients (90%) achieved an obliteration of the DCCF (93% in the XKnife cohort and 88% for the GKS cohort). In 34 of 40 patients (85%) with chemosis and proptosis of the eyes, these symptoms were resolved after treatment (4 had residual fistula and 2 had arterializations of sclera). All 5 patients with high intraocular pressure demonstrated clinical improvement. Ten (71%) of 14 patients with cranial nerve palsy demonstrated improvement following radiosurgery. Significant discrepancies of treatment modalities existed between the XKnife and GKS groups, such as radiation volume, conformity index, number of isocenters, instrument accuracy, peripheral isodose line, and maximum dosage. The XKnife delivered significantly higher radiation dosage to the lens, optic nerve, optic chiasm, bilateral temporal lobe, and brainstem. Few adverse events occurred, but included 1 patient with optic neuritis (GKS group), 1 intracranial hemorrhage (XKnife group), 1 brainstem edema (XKnife), and 3 temporal lobe radiation edemas (XKnife). Radiosurgery affords a substantial chance of radiological and clinical improvement in patients with DCCFs. The Gamma Knife and XKnife demonstrated similar efficacy in the obliteration of DCCFs. However, a slightly higher incidence of complications occurred in the XKnife group.

Original languageEnglish
Pages (from-to)9-20
Number of pages12
JournalJournal of Neurosurgery
Volume113 Suppl
Publication statusPublished - Dec 2010
Externally publishedYes

Fingerprint

Carotid-Cavernous Sinus Fistula
Radiosurgery
Fistula
Temporal Lobe
Radiation
Brain Stem
Edema
Optic Chiasm
Cranial Nerve Diseases
Radiation Dosage
Optic Neuritis
Cerebral Angiography
Sclera
Exophthalmos
Intracranial Hemorrhages
Optic Nerve
Intraocular Pressure
Lenses

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Pan, H. C., Sun, M. H., Sheehan, J., Sheu, M. L., Chen, C. C. C., Lee, H. T., ... Yang, D. Y. (2010). Radiosurgery for dural carotid-cavernous sinus fistulas: Gamma Knife compared with XKnife radiosurgery. Journal of Neurosurgery, 113 Suppl, 9-20.

Radiosurgery for dural carotid-cavernous sinus fistulas : Gamma Knife compared with XKnife radiosurgery. / Pan, Hung Chuan; Sun, Ming Hsi; Sheehan, Jason; Sheu, Meei Ling; Chen, Clayton Chi Chang; Lee, Hsu Tung; Chiu, Wen Ta; Yang, Dar Yu.

In: Journal of Neurosurgery, Vol. 113 Suppl, 12.2010, p. 9-20.

Research output: Contribution to journalArticle

Pan, HC, Sun, MH, Sheehan, J, Sheu, ML, Chen, CCC, Lee, HT, Chiu, WT & Yang, DY 2010, 'Radiosurgery for dural carotid-cavernous sinus fistulas: Gamma Knife compared with XKnife radiosurgery.', Journal of Neurosurgery, vol. 113 Suppl, pp. 9-20.
Pan HC, Sun MH, Sheehan J, Sheu ML, Chen CCC, Lee HT et al. Radiosurgery for dural carotid-cavernous sinus fistulas: Gamma Knife compared with XKnife radiosurgery. Journal of Neurosurgery. 2010 Dec;113 Suppl:9-20.
Pan, Hung Chuan ; Sun, Ming Hsi ; Sheehan, Jason ; Sheu, Meei Ling ; Chen, Clayton Chi Chang ; Lee, Hsu Tung ; Chiu, Wen Ta ; Yang, Dar Yu. / Radiosurgery for dural carotid-cavernous sinus fistulas : Gamma Knife compared with XKnife radiosurgery. In: Journal of Neurosurgery. 2010 ; Vol. 113 Suppl. pp. 9-20.
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