Radiolocalized sentinel lymph node biopsy in squamous cell carcinoma of the oral cavity and analysis of various parameters

Ching Yu Yen, Sheng Yang Lee, Jih Fang Hsieh, Dun Zheng Wang, Gin Nan Lin, Chih Mong Tsai, Shyun Yui Liu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Sentinel lymph node (SLN) biopsy seems to be a method that solves the problem of neck management with oral squamous cell carcinoma. Using blue dye methods for detection of neck SLNs from the surface of the operative field seems difficult; therefore, we used radiolocalization alone to detect and extract sentinel nodes. Aside from the various histological and clinical parameters examined in this procedure, we also determined whether they had any clinical significance in relation to the detection of SLNs during the operation. Methods: Enrolled subjects had preoperative clinical N0 stage squamous cell carcinoma of the oral cavity and had received an unfiltered 99mTc sulfur colloid peritumoral injection. Localization of the SLNs was performed by using lymphoscintigraphy and a handheld gamma probe. Results: In total, 28 oral squamous cell carcinoma patients were included in this prospective study. Sixty-four SLNs in 27 patients were identified by this method. The identification rate was 96.4%. No false-negative predictions of SLN were noted among any of the patients studied. The numbers of the SLNs found during the operation were larger in patients with positive findings than those with negative findings (P <.05 by the Mann-Whitney U-test). Conclusions: SLN radiolocalization provided an acceptable identification rate. The cases of positive findings for metastasis seemed to statistically have more SLNs than did those with negative findings, but more evidence is needed to prove this point. Therefore, SLN biopsies for extracting all possible high-risk nodes may be conducive for oral squamous cell carcinoma surgery. Published by Springer Science+Business Media, Inc.

Original languageEnglish
Pages (from-to)1130-1135
Number of pages6
JournalAnnals of Surgical Oncology
Volume13
Issue number8
DOIs
Publication statusPublished - Aug 2006

Fingerprint

Sentinel Lymph Node Biopsy
Mouth
Squamous Cell Carcinoma
Neck
Lymphoscintigraphy
Colloids
Nonparametric Statistics
Sulfur
Coloring Agents
Prospective Studies
Neoplasm Metastasis
Injections

Keywords

  • Oral cavity
  • Radiolocalized
  • Sentinel lymph node biopsy
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Radiolocalized sentinel lymph node biopsy in squamous cell carcinoma of the oral cavity and analysis of various parameters. / Yen, Ching Yu; Lee, Sheng Yang; Hsieh, Jih Fang; Wang, Dun Zheng; Lin, Gin Nan; Tsai, Chih Mong; Liu, Shyun Yui.

In: Annals of Surgical Oncology, Vol. 13, No. 8, 08.2006, p. 1130-1135.

Research output: Contribution to journalArticle

Yen, Ching Yu ; Lee, Sheng Yang ; Hsieh, Jih Fang ; Wang, Dun Zheng ; Lin, Gin Nan ; Tsai, Chih Mong ; Liu, Shyun Yui. / Radiolocalized sentinel lymph node biopsy in squamous cell carcinoma of the oral cavity and analysis of various parameters. In: Annals of Surgical Oncology. 2006 ; Vol. 13, No. 8. pp. 1130-1135.
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abstract = "Background: Sentinel lymph node (SLN) biopsy seems to be a method that solves the problem of neck management with oral squamous cell carcinoma. Using blue dye methods for detection of neck SLNs from the surface of the operative field seems difficult; therefore, we used radiolocalization alone to detect and extract sentinel nodes. Aside from the various histological and clinical parameters examined in this procedure, we also determined whether they had any clinical significance in relation to the detection of SLNs during the operation. Methods: Enrolled subjects had preoperative clinical N0 stage squamous cell carcinoma of the oral cavity and had received an unfiltered 99mTc sulfur colloid peritumoral injection. Localization of the SLNs was performed by using lymphoscintigraphy and a handheld gamma probe. Results: In total, 28 oral squamous cell carcinoma patients were included in this prospective study. Sixty-four SLNs in 27 patients were identified by this method. The identification rate was 96.4{\%}. No false-negative predictions of SLN were noted among any of the patients studied. The numbers of the SLNs found during the operation were larger in patients with positive findings than those with negative findings (P <.05 by the Mann-Whitney U-test). Conclusions: SLN radiolocalization provided an acceptable identification rate. The cases of positive findings for metastasis seemed to statistically have more SLNs than did those with negative findings, but more evidence is needed to prove this point. Therefore, SLN biopsies for extracting all possible high-risk nodes may be conducive for oral squamous cell carcinoma surgery. Published by Springer Science+Business Media, Inc.",
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AU - Lee, Sheng Yang

AU - Hsieh, Jih Fang

AU - Wang, Dun Zheng

AU - Lin, Gin Nan

AU - Tsai, Chih Mong

AU - Liu, Shyun Yui

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N2 - Background: Sentinel lymph node (SLN) biopsy seems to be a method that solves the problem of neck management with oral squamous cell carcinoma. Using blue dye methods for detection of neck SLNs from the surface of the operative field seems difficult; therefore, we used radiolocalization alone to detect and extract sentinel nodes. Aside from the various histological and clinical parameters examined in this procedure, we also determined whether they had any clinical significance in relation to the detection of SLNs during the operation. Methods: Enrolled subjects had preoperative clinical N0 stage squamous cell carcinoma of the oral cavity and had received an unfiltered 99mTc sulfur colloid peritumoral injection. Localization of the SLNs was performed by using lymphoscintigraphy and a handheld gamma probe. Results: In total, 28 oral squamous cell carcinoma patients were included in this prospective study. Sixty-four SLNs in 27 patients were identified by this method. The identification rate was 96.4%. No false-negative predictions of SLN were noted among any of the patients studied. The numbers of the SLNs found during the operation were larger in patients with positive findings than those with negative findings (P <.05 by the Mann-Whitney U-test). Conclusions: SLN radiolocalization provided an acceptable identification rate. The cases of positive findings for metastasis seemed to statistically have more SLNs than did those with negative findings, but more evidence is needed to prove this point. Therefore, SLN biopsies for extracting all possible high-risk nodes may be conducive for oral squamous cell carcinoma surgery. Published by Springer Science+Business Media, Inc.

AB - Background: Sentinel lymph node (SLN) biopsy seems to be a method that solves the problem of neck management with oral squamous cell carcinoma. Using blue dye methods for detection of neck SLNs from the surface of the operative field seems difficult; therefore, we used radiolocalization alone to detect and extract sentinel nodes. Aside from the various histological and clinical parameters examined in this procedure, we also determined whether they had any clinical significance in relation to the detection of SLNs during the operation. Methods: Enrolled subjects had preoperative clinical N0 stage squamous cell carcinoma of the oral cavity and had received an unfiltered 99mTc sulfur colloid peritumoral injection. Localization of the SLNs was performed by using lymphoscintigraphy and a handheld gamma probe. Results: In total, 28 oral squamous cell carcinoma patients were included in this prospective study. Sixty-four SLNs in 27 patients were identified by this method. The identification rate was 96.4%. No false-negative predictions of SLN were noted among any of the patients studied. The numbers of the SLNs found during the operation were larger in patients with positive findings than those with negative findings (P <.05 by the Mann-Whitney U-test). Conclusions: SLN radiolocalization provided an acceptable identification rate. The cases of positive findings for metastasis seemed to statistically have more SLNs than did those with negative findings, but more evidence is needed to prove this point. Therefore, SLN biopsies for extracting all possible high-risk nodes may be conducive for oral squamous cell carcinoma surgery. Published by Springer Science+Business Media, Inc.

KW - Oral cavity

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