Radioimmunotherapy of xenografted human bladder cancer using monoclonal antibody against blood group A-related antigen

M. Y. Yeh, D. S. Yu, S. Y. Chang, C. P. Ma, S. H. Han

Research output: Contribution to journalArticle

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Abstract

An IgG3 murine monoclonal antibody 1G3.10 was generated against a human urinary bladder carcinoma cell line TSGH-8301. The tumor-associated antigen recognized by the monoclonal antibody is a blood group A-related substance. From fluorescence-activated cell sorter analysis, a direct cytolytic effect of tumor cells by the antibody at concentrations of more than 10 μg/ml was seen. The antibody could target iodine-131 to established subcutaneous human bladder carcinoma xenografts in BALB/c nude mice. Monoclonal antibody alone also showed some inhibitory effect on xenografted tumor growth. In this study, radiolabeled monoclonal antibody 1G3.10 presented more effective cytotoxicity than antibody alone from in vitro and in vivo experiments.

Original languageEnglish
Pages (from-to)386-390
Number of pages5
JournalEuropean Urology
Volume14
Issue number5
DOIs
Publication statusPublished - Jan 1 1988
Externally publishedYes

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Radioimmunotherapy
Blood Group Antigens
Urinary Bladder Neoplasms
Monoclonal Antibodies
Antigens
Urinary Bladder
Neoplasm Antibodies
Carcinoma
Antibodies
Neoplasm Antigens
Heterografts
Nude Mice
Iodine
Immunoglobulin G
Fluorescence
Cell Line
Growth
Neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

Radioimmunotherapy of xenografted human bladder cancer using monoclonal antibody against blood group A-related antigen. / Yeh, M. Y.; Yu, D. S.; Chang, S. Y.; Ma, C. P.; Han, S. H.

In: European Urology, Vol. 14, No. 5, 01.01.1988, p. 386-390.

Research output: Contribution to journalArticle

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