Radiation-Sensitive Dendrimer-Based Drug Delivery System

Szu Yuan Wu, Hsiao Ying Chou, Chiou Hwa Yuh, Shewaye Lakew Mekuria, Yu Chih Kao, Hsieh Chih Tsai

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Combination of chemotherapy and radiotherapy is used to enhance local drug delivery while reducing off-target tissue effects. Anticancer drug doxorubicin (DOX) is loaded into l-cysteine modified G4.5 dendrimer (GC/DOX) and released at different pH values in the presence and absence of γ-radiation. Presence of γ-radiation significantly improves DOX release from the GC/DOX under acidic pH conditions, suggesting that GC dendrimer is a radiation-sensitive drug delivery system. GC/DOX is further evaluated by determining cytotoxicity in uterine cervical carcinoma HeLa cells. GC/DOX shows high affinity for cancer cells and effective drug release following an external stimulus (radiation exposure), whereas an in vivo zebrafish study confirms that l-cysteine acts as a radiosensitizer. GC/DOX treatment combined with radiotherapy synergistically and successfully inhibits cancer cell growth.

Original languageEnglish
JournalAdvanced Science
Volume5
Issue number2
DOIs
Publication statusPublished - Feb 2018

Fingerprint

Dendrimers
dendrimers
Drug Delivery Systems
Doxorubicin
delivery
drugs
Radiation
cancer
cysteine
Radiotherapy
radiation
radiation therapy
Chemotherapy
radiation dosage
Cell growth
chemotherapy
Cytotoxicity
Cysteine
Drug delivery
stimuli

Keywords

  • Combination therapies
  • Dendrimers
  • Doxorubicin
  • HeLa cells
  • Zebrafish

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Chemical Engineering(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Wu, S. Y., Chou, H. Y., Yuh, C. H., Mekuria, S. L., Kao, Y. C., & Tsai, H. C. (2018). Radiation-Sensitive Dendrimer-Based Drug Delivery System. Advanced Science, 5(2). https://doi.org/10.1002/advs.201700339

Radiation-Sensitive Dendrimer-Based Drug Delivery System. / Wu, Szu Yuan; Chou, Hsiao Ying; Yuh, Chiou Hwa; Mekuria, Shewaye Lakew; Kao, Yu Chih; Tsai, Hsieh Chih.

In: Advanced Science, Vol. 5, No. 2, 02.2018.

Research output: Contribution to journalArticle

Wu, SY, Chou, HY, Yuh, CH, Mekuria, SL, Kao, YC & Tsai, HC 2018, 'Radiation-Sensitive Dendrimer-Based Drug Delivery System', Advanced Science, vol. 5, no. 2. https://doi.org/10.1002/advs.201700339
Wu, Szu Yuan ; Chou, Hsiao Ying ; Yuh, Chiou Hwa ; Mekuria, Shewaye Lakew ; Kao, Yu Chih ; Tsai, Hsieh Chih. / Radiation-Sensitive Dendrimer-Based Drug Delivery System. In: Advanced Science. 2018 ; Vol. 5, No. 2.
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